INT50012

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Context Info
Confidence 0.28
First Reported 1995
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.82
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

CHR (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 6 99.20 Very High Very High Very High
agonist 2 98.68 Very High Very High Very High
depression 2 96.80 Very High Very High Very High
Endogenous opioid 2 94.32 High High
Opioid 4 93.40 High High
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 95 100.00 Very High Very High Very High
Depression 2 96.80 Very High Very High Very High
Adenoma 4 94.72 High High
Cancer 45 89.48 High High
Renal Cancer 18 73.04 Quite High
Adhesions 9 13.92 Low Low
Metastasis 3 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional taxonomy: Genes differentially regulated in CC and Chr
Regulation (regulated) of Chr associated with carcinoma
1) Confidence 0.28 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.65 Pain Relevance 0
ChR desensitization is regulated not by one but by several known second messengers and G-proteins.
Neg (not) Regulation (regulated) of ChR
2) Confidence 0.05 Published 1995 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 7599972 Disease Relevance 0.10 Pain Relevance 0.54
Second messengers are involved in intracellular mechanism of modulation of the ChR desensitization by opiate kappa-agonist bremazocine.
Regulation (modulation) of ChR associated with agonist and opiate
3) Confidence 0.05 Published 1995 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 7599972 Disease Relevance 0.08 Pain Relevance 0.63

General Comments

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