INT50012

Context Info Confidence 0.28 First Reported 1995 Last Reported 2002 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.82 Pain Relevance 1.16

CHR (Homo sapiens)

Pain Link Frequency Relevance Heat opiate 6 99.20 agonist 2 98.68 depression 2 96.80 Endogenous opioid 2 94.32 Opioid 4 93.40 palliative 1 5.00

Disease Link Frequency Relevance Heat Carcinoma 95 100.00 Depression 2 96.80 Adenoma 4 94.72 Cancer 45 89.48 Renal Cancer 18 73.04 Adhesions 9 13.92 Metastasis 3 5.00 Breast Cancer 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Functional taxonomy: Genes differentially regulated in CC and Chr

Regulation (regulated) of Chr associated with carcinoma

1) Confidence 0.28 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.65 Pain Relevance 0

ChR desensitization is regulated not by one but by several known second messengers and G-proteins.

Neg (not) Regulation (regulated) of ChR

2) Confidence 0.05 Published 1995 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 7599972 Disease Relevance 0.10 Pain Relevance 0.54

Second messengers are involved in intracellular mechanism of modulation of the ChR desensitization by opiate kappa-agonist bremazocine.

Regulation (modulation) of ChR associated with agonist and opiate

3) Confidence 0.05 Published 1995 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 7599972 Disease Relevance 0.08 Pain Relevance 0.63

General Comments

This test has worked.