INT50022

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.47
Pain Relevance 3.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
blood 2
plasma 2
tail 1
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 67 100.00 Very High Very High Very High
antinociception 4 94.00 High High
Bile 7 93.44 High High
tail-flick 3 91.40 High High
Analgesic 2 84.72 Quite High
Antinociceptive 8 82.40 Quite High
tolerance 1 27.60 Quite Low
Pain 2 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Gallstones 6 80.00 Quite High
Cancer 4 75.00 Quite High
Disorders Of Creatine Metabolism 2 71.72 Quite High
Diabetes Mellitus 2 51.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M3G elimination from serum was rapid in BC rats; in contrast, M3G residence was prolonged in intact animals.
Positive_regulation (prolonged) of M3G
1) Confidence 0.42 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 7600915 Disease Relevance 0 Pain Relevance 0.55
M3G exposure had no significant effect on morphine pharmacokinetics, although a disproportionate increase in M3G concentrations was observed following the morphine i.v. bolus dose in rats infused with high dose M3G.
Positive_regulation (increase) of M3G associated with morphine
2) Confidence 0.32 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9260872 Disease Relevance 0 Pain Relevance 1.46
CONCLUSIONS: In STZ-diabetic rats, the distribution volume of morphine increased, the glucuronidation rate and M3G transportation into the blood were enhanced, and the excretion of M3G was decreased, leading to an increase in the plasma M3G concentration.


Positive_regulation (increase) of M3G in blood
3) Confidence 0.19 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487213 Disease Relevance 0.05 Pain Relevance 0
Plasma M3G concentrations on day 1 after BDL were similar to those in the untreated control group, but were increased 3 and 5 days after BDL.
Positive_regulation (increased) of M3G in Plasma
4) Confidence 0.14 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703370 Disease Relevance 0.08 Pain Relevance 0
The urinary excretion of M3G was increased significantly after BDL.
Positive_regulation (increased) of M3G
5) Confidence 0.11 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703370 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Enhanced glucuronidation of morphine and transportation of M3G into the blood increased the plasma M3G concentration in the BDL groups.
Positive_regulation (increased) of M3G in blood
6) Confidence 0.10 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703370 Disease Relevance 0.07 Pain Relevance 0
Accumulation of M3G in plasma of aged rats is probably due to diminished renal clearance of M3G in addition to a reduction in the biliary excretion of M3G.
Positive_regulation (Accumulation) of M3G in plasma
7) Confidence 0.05 Published 1997 Journal Pain Section Abstract Doc Link 9211481 Disease Relevance 0.12 Pain Relevance 0.94
CONCLUSIONS: Pretreatment with GF120918 enhanced morphine antinociception, as assessed by the hot-lamp tail-flick assay, and elevated systemic M3G concentrations in rats.
Positive_regulation (elevated) of M3G in tail
8) Confidence 0.03 Published 1998 Journal Pharm. Res. Section Body Doc Link 9587957 Disease Relevance 0 Pain Relevance 0
Moreover, the contribution of UGT1A1 to the formation of M3G appears to be of minor biological significance, at least in a UGT2B7 background.


Positive_regulation (formation) of M3G
9) Confidence 0.00 Published 2002 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 12185559 Disease Relevance 0 Pain Relevance 0
Studies in rats have indicated that UGT1A1 may also contribute to the formation of morphine 3-glucuronide (M3G).
Positive_regulation (formation) of M3G associated with morphine
10) Confidence 0.00 Published 2002 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 12185559 Disease Relevance 0.07 Pain Relevance 0.77

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