INT50038

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 6.89
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
eosinophils 3
plasma 2
lymphocyte 2
Th2 cell 1
Il5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 36 100.00 Very High Very High Very High
Migraine 18 99.96 Very High Very High Very High
Sumatriptan 2 98.82 Very High Very High Very High
abdominal pain 4 93.76 High High
carbamazepine 3 92.68 High High
Chronic pancreatitis 3 86.32 High High
anticonvulsant 1 85.24 High High
Inflammatory mediators 3 80.96 Quite High
Inflammation 45 79.56 Quite High
anesthesia 1 65.92 Quite High
Disease Link Frequency Relevance Heat
Headache 12 99.96 Very High Very High Very High
Pressure And Volume Under Development 10 99.68 Very High Very High Very High
Peritonitis 6 99.68 Very High Very High Very High
Rhinitis 6 99.20 Very High Very High Very High
Disease 10 99.08 Very High Very High Very High
Hypersensitivity 10 99.02 Very High Very High Very High
Migraine Without Aura 6 97.60 Very High Very High Very High
Abdominal Pain 4 93.76 High High
Diarrhoea 3 92.96 High High
Vomiting 6 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum concentrations of interleukin 5 and interleukin 3 were normal, while only interleukin 5 level in the ascites presented at a high level; interleukin 5 at the affected part may be specifically related to the intestinal recruitment of eosinophils in this disease.
Positive_regulation (level) of interleukin 5 in eosinophils associated with pressure and volume under development and disease
1) Confidence 0.41 Published 2000 Journal Hepatogastroenterology Section Abstract Doc Link 11149008 Disease Relevance 1.06 Pain Relevance 0.09
Serum concentrations of interleukin 5 and interleukin 3 were normal, while only interleukin 5 level in the ascites presented at a high level; interleukin 5 at the affected part may be specifically related to the intestinal recruitment of eosinophils in this disease.
Positive_regulation (concentrations) of interleukin 5 in eosinophils associated with pressure and volume under development and disease
2) Confidence 0.41 Published 2000 Journal Hepatogastroenterology Section Abstract Doc Link 11149008 Disease Relevance 1.08 Pain Relevance 0.09
Serum concentrations of interleukin 5 and interleukin 3 were normal, while only interleukin 5 level in the ascites presented at a high level; interleukin 5 at the affected part may be specifically related to the intestinal recruitment of eosinophils in this disease.
Positive_regulation (level) of interleukin 5 in eosinophils associated with pressure and volume under development and disease
3) Confidence 0.41 Published 2000 Journal Hepatogastroenterology Section Abstract Doc Link 11149008 Disease Relevance 1.05 Pain Relevance 0.09
IL-1beta, IL-6, IL-5, and IL-10 were immediately up-regulated in the acute phase of disease, while lymphocyte-restricted expression of IL-2, IL-2R, and IFN-y was only found in the chronic course.
Positive_regulation (up-regulated) of IL-5 in lymphocyte associated with disease
4) Confidence 0.27 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11508663 Disease Relevance 0.51 Pain Relevance 0.47
Cytokines and migraine: increase of IL-5 and IL-4 plasma levels.
Positive_regulation (increase) of IL-5 in plasma associated with migraine and cytokine
5) Confidence 0.08 Published 1998 Journal Headache Section Title Doc Link 9664752 Disease Relevance 0.37 Pain Relevance 0.62
Of interest, we observed a strong increase of IL-5 levels in 84.3% as well as increased IL-4 levels in 37.5% of patients with migraine without aura.
Positive_regulation (increase) of IL-5 associated with migraine
6) Confidence 0.08 Published 1998 Journal Headache Section Abstract Doc Link 9664752 Disease Relevance 0.34 Pain Relevance 0.54
After treatment with sumatriptan, 10 patients showed a subsequent decrease in IL-10 and an increase in both IL-4 and IL-5 plasma levels.
Positive_regulation (increase) of IL-5 in plasma associated with sumatriptan
7) Confidence 0.07 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.24 Pain Relevance 0.50
Although these findings are derived from a limited number of patients, the apparent return to the IL-4 and IL-5 cytokine profile observed during the interictal period leads us to speculate that a preferential enhancement of TH2-type cytokine production may contribute to the pathogenesis of migraine.
Positive_regulation (observed) of IL-5 associated with migraine and cytokine
8) Confidence 0.03 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.32 Pain Relevance 0.51
In the late-phase allergic response, cytokines such as interleukin (IL)-4, IL-5, IL-6, IL-8, IL-13, and TNF are induced and secreted [30].
Positive_regulation (induced) of IL-5 associated with hypersensitivity and cytokine
9) Confidence 0.03 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.67 Pain Relevance 0.25
The concentrations of TNF-alpha, GM-CSF, interleukin (IL)-1beta, IL-6, IL-8, interferon (IFN)-gamma, IL-2, IL-4, IL-5, IL-10 and nitrate/nitrite were determined.
Spec (determined) Positive_regulation (concentrations) of IL-5
10) Confidence 0.01 Published 2007 Journal Inflamm. Res. Section Body Doc Link 17334668 Disease Relevance 0.17 Pain Relevance 0
Drug-activated lymphocytes secreted high amounts of IL-5 and normal or low levels of IL-2, IFN-gamma, IL-4, and TNF-alpha.
Positive_regulation (amounts) of IL-5 in lymphocytes
11) Confidence 0.01 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7602118 Disease Relevance 0.80 Pain Relevance 0.26
Evidence suggests that surgery induces a predominant activation pattern through the T-helper-2 (Th2) cell pathway, increasing interleukins (IL-4, IL-5, IL-10, IL-13), inhibiting Th1 cell activation, and promoting B and Th2 cell activation.
Positive_regulation (increasing) of IL-5 in Th2 cell
12) Confidence 0.00 Published 2001 Journal World J Surg Section Abstract Doc Link 11369984 Disease Relevance 0.28 Pain Relevance 0.07

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