INT50039

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Context Info
Confidence 0.55
First Reported 1995
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 48
Total Number 50
Disease Relevance 34.80
Pain Relevance 23.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
plasma 3
lymph node 3
lymphocytes 3
epithelial cell 2
cerebrospinal fluid 1
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 414 100.00 Very High Very High Very High
cytokine 339 100.00 Very High Very High Very High
chemokine 12 100.00 Very High Very High Very High
Migraine 23 99.96 Very High Very High Very High
fluoxetine 18 99.84 Very High Very High Very High
Peripheral nervous system 17 99.84 Very High Very High Very High
Multiple sclerosis 13 99.84 Very High Very High Very High
Morphine 26 99.80 Very High Very High Very High
Analgesic 24 99.64 Very High Very High Very High
qutenza 18 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 460 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Cancer 18 100.00 Very High Very High Very High
Cold Sores 88 99.98 Very High Very High Very High
Headache 16 99.96 Very High Very High Very High
Diabetes Mellitus 242 99.84 Very High Very High Very High
Demyelinating Disease 15 99.84 Very High Very High Very High
Nociception 32 99.78 Very High Very High Very High
Bordatella Infection 4 99.56 Very High Very High Very High
Immunization 7 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-4/IL-2 ratio was significantly increased in fluoxetine group respecting the controls and was similar during the 3 weeks of treatment.
Positive_regulation (increased) of IL-4 associated with fluoxetine
1) Confidence 0.55 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.16 Pain Relevance 1.05
In the former group, IL-4 and MCP-1 were also significantly increased in the lung draining lymph nodes.
Positive_regulation (creased i) of IL-4 in lymph nodes
2) Confidence 0.48 Published 2006 Journal Toxicology Section Abstract Doc Link 17011108 Disease Relevance 0.43 Pain Relevance 0.96
The H2-blocker, ebrotidine, also known for its gastroprotective effects, reduced the indomethacin-induced lesions by 90.2%, epithelial cell apoptosis decreased by 61% and ET-1 showed a 58.2% decline, while IL-4 increased by 30.6% and that of cNOS showed a 3.1-fold increase.
Positive_regulation (increased) of IL-4 in epithelial cell associated with apoptosis
3) Confidence 0.41 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.59 Pain Relevance 0.07
In the absence of antiulcer agents, indomethacin caused multiple hemorrhagic lesions and extensive epithelial cell apoptosis, accompanied by a 20.7% reduction in IL-4, a 3.1-fold increase in mucosal expression of ET-1 and a 4.2-fold decline in cNOS.
Positive_regulation (increase) of IL-4 in epithelial cell associated with apoptosis
4) Confidence 0.41 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.61 Pain Relevance 0.11
The time course of the analgesic effect of vector-mediated IL-4 observed in this study is similar to the time course on the analgesic effects that we have observed in experiments using HSV-mediated gene transfer to DRG to produce the release of enkephalin [20,21]and GABA [24,36].
Positive_regulation (mediated) of IL-4 associated with dorsal root ganglion, gaba, cold sores, analgesic and enkephalin
5) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.06 Pain Relevance 1.13
In the gene transfer experiments reported herein we have not established the locus of action of the HSV-mediated IL-4.
Positive_regulation (mediated) of IL-4 associated with cold sores
6) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.02 Pain Relevance 0.88
Furthermore, Radix Astragali significantly attenuated elevated levels of the Th1 cytokines (IFN-gamma and IL-2), and increased the Th2 cytokines (IL-4 and IL-10) in autoimmune myocarditis.
Positive_regulation (increased) of IL-4 associated with myocarditis and cytokine
7) Confidence 0.38 Published 2008 Journal Toxicol. Lett. Section Abstract Doc Link 18782607 Disease Relevance 1.24 Pain Relevance 0.31
Fluoxetine administration elevated the levels of IL-4 at 1, 2 and 3 weeks; and of IL-2, at 2 and 3 weeks.
Positive_regulation (elevated) of IL-4 associated with fluoxetine
8) Confidence 0.37 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.17 Pain Relevance 1.04
S4IL4 (Figure 1a) was generated as described [44] by Cre-lox recombination of a plasmid containing the HSV ICP4 promoter, murine IL-4, an HCMV-?
Positive_regulation (generated) of S4IL4 associated with cold sores
9) Confidence 0.35 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.46 Pain Relevance 0.88
Anti-nociceptive effect of inoculation of S4IL4
Positive_regulation (inoculation) of S4IL4 associated with nociception
10) Confidence 0.35 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.11 Pain Relevance 0.81
In contrast, pro-inflammatory cytokines, the Th2 cell cytokine IL-4, and the CC-chemokine MCP-1 were significantly increased in BAL-cells of capsaicin pretreated and MDI-sensitized rats, whilst in the normal MDI-sensitized rats markedly less pronounced changes (if any) occurred.
Positive_regulation (increased) of IL-4 in Th2 cell associated with chemokine, qutenza, inflammation and cytokine
11) Confidence 0.34 Published 2006 Journal Toxicology Section Abstract Doc Link 17011108 Disease Relevance 0.38 Pain Relevance 0.94
There is little controversy about the requirements for IL-4 in the induction of airway inflammation and AHR [34], while IL-13 direct causes AHR and mucus overproduction in asthma [35,36].
Positive_regulation (requirements) of IL-4 associated with asthma and inflammation
12) Confidence 0.31 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.22 Pain Relevance 0.55
Nebulized ketamine at concentrations of 12.5 or 25 mg/ml significantly lessened OVA-induced airway inflammation and the induction of iNOS, IL-4 and NO in an experimental model of asthma.
Positive_regulation (induction) of IL-4 associated with asthma, inflammation and ketamine
13) Confidence 0.29 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.16 Pain Relevance 0.73
It also resulted in an increase in the levels of IL-4 (132.1 ± 22.9 pg/mL), which was even higher than the controls (Figure 2).
Positive_regulation (increase) of IL-4
14) Confidence 0.28 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.76 Pain Relevance 0.12
(P < 0.05) and increased the levels of IL-4 (P < 0.05).
Positive_regulation (increased) of IL-4
15) Confidence 0.28 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3004822 Disease Relevance 0.71 Pain Relevance 0.06
However, in further investigations we did not find any direct evidence of the ability of melatonin to stimulate IL4.
Positive_regulation (stimulate) of IL4
16) Confidence 0.28 Published 1996 Journal J. Pineal Res. Section Abstract Doc Link 8981257 Disease Relevance 0.17 Pain Relevance 0.37
The infiltration of CD4(+) and CD8(+) T cells and the sera level of IFN-gamma and TNF-alpha were decreased significantly (P<0.05), whereas IL-4 level in the supernatant of cultured lymphocytes was increased (P<0.05).
Positive_regulation (increased) of IL-4 in lymphocytes
17) Confidence 0.23 Published 2007 Journal Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Section Body Doc Link 17210108 Disease Relevance 0.07 Pain Relevance 0
In conclusion, the current study has demonstrated the in vivo anti-inflammatory and analgesic effects of PSF, and suggested that the molecular mechanisms might be associated with inhibition of the elevated expression of COX-2 protein and the overproduction of the proinflammatory cytokines, as well as augmentation of the anti-inflammatory cytokines IL-4 and IL-10 in the carrageenan-injected paw tissues of rats.
Positive_regulation (augmentation) of cytokines IL-4 in paw associated with inflammation, analgesic and cytokine
18) Confidence 0.23 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18379056 Disease Relevance 0.57 Pain Relevance 0.64
Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system.
Positive_regulation (up-regulation) of IL-4 in peripheral nervous system associated with chemokine, peripheral nervous system, inflammation, experimental autoimmune neuritis and neuritis
19) Confidence 0.22 Published 2000 Journal Autoimmunity Section Title Doc Link 11078155 Disease Relevance 1.28 Pain Relevance 0.89
Thus, the resulting reduction in the inflammation in the AZL treated group was due to the stimulation of IL-4 but probably not due the production of anti-inflammatory cytokine IL-10.
Positive_regulation (stimulation) of IL-4 associated with inflammation and cytokine
20) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 1.70 Pain Relevance 0.52

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