INT50040

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 8.26
Pain Relevance 7.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T-cell 3
Th2 cells 2
monocytes 1
lymphocytes 1
P815 1
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 114 99.98 Very High Very High Very High
qutenza 6 99.64 Very High Very High Very High
ketamine 136 98.84 Very High Very High Very High
Inflammation 162 97.68 Very High Very High Very High
Sciatic nerve 2 97.20 Very High Very High Very High
tetrodotoxin 7 97.04 Very High Very High Very High
aspirin 8 96.56 Very High Very High Very High
Opioid 4 96.12 Very High Very High Very High
Root ganglion neuron 5 95.88 Very High Very High Very High
Arthritis 72 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 179 97.68 Very High Very High Very High
Immunization 3 95.98 Very High Very High Very High
Arthritis 48 95.56 Very High Very High Very High
Disease 32 95.56 Very High Very High Very High
Asthma 60 95.48 Very High Very High Very High
Pancreatitis 160 95.20 Very High Very High Very High
Systemic Lupus Erythematosus 6 94.72 High High
Injury 14 94.28 High High
Rheumatoid Arthritis 34 92.32 High High
Hypersensitivity 15 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects were associated with T and B cells hyporesponsiveness to the peptide antigens, reflected by downregulated Th1 cell responses (interferon-gamma secretion) and macrophage function, whereas Th2 cell responses (IL-4 secretion) and transforming growth factor-beta mRNA expression were upregulated.
Localization (secretion) of IL-4 in Th2 cell
1) Confidence 0.67 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10376943 Disease Relevance 0.69 Pain Relevance 0.58
On the 14th day after immunization, we examined lymphocyte proliferation, fractions of CD4+ T cells within lymph node mononuclear cells (MNC), frequencies of CD4+CD25+ T cells within CD4+ T cells, supernatant productions of IFN-gamma, IL-4, IL-10 and TGF-beta1 secreted by lymphocytes.
Localization (secreted) of IL-4 in mononuclear cells associated with immunization
2) Confidence 0.53 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17346805 Disease Relevance 0.33 Pain Relevance 0.12
g/kg significantly down-regulate Th2 cytokine IL-4 secretion in BALF, which suggest that ketamine treatment could alleviate IL-4-mediated responses, airway inflammation and AHR.
Localization (secretion) of IL-4 associated with asthma, inflammation, ketamine and cytokine
3) Confidence 0.41 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.45 Pain Relevance 0.65
relation between IL-4 and ERCP in the literature.
Localization (relation) of IL-4
4) Confidence 0.12 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.87 Pain Relevance 0.36
serum IL-2, IL-4, TNF?
Localization (serum) of IL-4
5) Confidence 0.12 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 1.07 Pain Relevance 0.37
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Localization (release) of IL-4 in microglia
6) Confidence 0.11 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.66
Although vanilloids did not cause degranulation in MCs, in the P815 clone capsaicin evoked selective interleukin-4 release.
Localization (release) of interleukin-4 in P815 associated with qutenza
7) Confidence 0.09 Published 1998 Journal Blood Section Abstract Doc Link 9454764 Disease Relevance 0.07 Pain Relevance 0.71
, whereas the counter-regulatory Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 [118].
Localization (secrete) of IL-4 in Th2 cells
8) Confidence 0.08 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 1.15 Pain Relevance 0.40
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Localization (secretion) of IL-4 in T-cell associated with injury
9) Confidence 0.05 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.11
In this study, we provide evidence that NCX-4016 delivered to PMBC-derived T lymphocytes and monocytes causes a transitory inhibition of cell respiration and approximately 50% reduction of cellular ATP, which translates in a time-reversible inhibition of cell proliferation and IL-2, IL-4, IL-5, and IFN-gamma secretion.
Localization (secretion) of IL-4 in monocytes
10) Confidence 0.04 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15240674 Disease Relevance 0.07 Pain Relevance 0.28
These endogenous substances can be released by "releasing factors" such as CRF and IL-4 via activation of their receptors on the cell surface of inflammatory cells.
Localization (released) of IL-4 associated with inflammation
11) Confidence 0.03 Published 2003 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 12617563 Disease Relevance 0.41 Pain Relevance 0.96
In addition, three CD4+ and all CD8+ (n = 7) clones secreted high IFN-gamma and low levels of IL-5/IL-4 (Th1-like).
Localization (secreted) of IL-4
12) Confidence 0.02 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9013953 Disease Relevance 0.32 Pain Relevance 0.73
Drug-activated lymphocytes secreted high amounts of IL-5 and normal or low levels of IL-2, IFN-gamma, IL-4, and TNF-alpha.
Localization (secreted) of IL-4 in lymphocytes
13) Confidence 0.02 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7602118 Disease Relevance 0.81 Pain Relevance 0.26
gynthesis and inhibitor of IL-4 secretion.
Localization (secretion) of IL-4
14) Confidence 0.02 Published 2004 Journal Crit Care Section Body Doc Link PMC420022 Disease Relevance 0.42 Pain Relevance 0.21
METHODS: Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) secreted by CD3+ CD8(-)T cells were detected by flow cytometry in 35 patients with CAP/CPPS and 12 healthy volunteers, and significance of Th1/Th2 cells ratio in the etiology of CAP/CPPS was analyzed.
Spec (analyzed) Localization (secreted) of interleukin-4 in T cells
15) Confidence 0.02 Published 2006 Journal Zhonghua Nan Ke Xue Section Body Doc Link 16683566 Disease Relevance 0 Pain Relevance 0
In this study, we provide evidence that NCX-4016 delivered to PMBC-derived T lymphocytes and monocytes causes a transitory inhibition of cell respiration and approximately 50% reduction of cellular ATP, which translates in a time-reversible inhibition of cell proliferation and IL-2, IL-4, IL-5, and IFN-gamma secretion.
Localization (secretion) of IL-4 in T lymphocytes
16) Confidence 0.01 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15240674 Disease Relevance 0.07 Pain Relevance 0.28

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