INT50056

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 3.16
Pain Relevance 13.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dll1) plasma membrane (Dll1) cell-cell signaling (Dll1)
Anatomy Link Frequency
neurons 1
brain 1
caudate-putamen 1
Spleen 1
thymus 1
Dll1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 31 100.00 Very High Very High Very High
Gabapentin 5 100.00 Very High Very High Very High
opioid receptor 72 99.96 Very High Very High Very High
antagonist 29 99.92 Very High Very High Very High
Cholecystokinin 18 99.68 Very High Very High Very High
Morphine 33 99.40 Very High Very High Very High
Eae 6 99.40 Very High Very High Very High
Opioid 28 99.38 Very High Very High Very High
Calcium channel 3 99.24 Very High Very High Very High
Endogenous opioid 3 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 99.36 Very High Very High Very High
Hypoxia 10 99.00 Very High Very High Very High
Amnesia 4 98.44 Very High Very High Very High
Nociception 3 98.44 Very High Very High Very High
Opiate Addiction 8 97.92 Very High Very High Very High
Morphine Dependence 2 95.56 Very High Very High Very High
Drug Dependence 3 95.28 Very High Very High Very High
Neuropathic Pain 7 92.32 High High
Hypothermia 1 82.04 Quite High
Body Weight 48 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of delta 1-opioid receptors by endogenous opioid peptides decreased the micro-opioid responses.
Positive_regulation (Activation) of delta 1 associated with endogenous opioid, opioid receptor and opioid
1) Confidence 0.67 Published 1996 Journal Neuroscience Section Abstract Doc Link 8951884 Disease Relevance 0 Pain Relevance 1.84
Furthermore, we found that mRNA and protein levels of the voltage-gated calcium channel (alpha 2)delta-1 subunit (Ca(alpha 2)delta-1), one of the putative targets for gabapentin, was up-regulated in dorsal root ganglions (DRGs), as well as increased expression of Ca(alpha 2)delta-1 protein in medium/large-sized DRG neurons by immunohistochemistry, following paclitaxel treatment.
Positive_regulation (up-regulated) of delta-1 in neurons associated with ganglion cysts, calcium channel and gabapentin
2) Confidence 0.67 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16687474 Disease Relevance 0.82 Pain Relevance 1.35
These results suggest that stimulation of delta 2-opioid receptors potentiates micro-opioid analgesia in the hot-plate test in mice through an increase in endogenous cholecystokinin release, while activation of delta 1-opioid receptors could decrease it.
Positive_regulation (activation) of delta 1 associated with opioid receptor, cholecystokinin, opioid and analgesia
3) Confidence 0.67 Published 1996 Journal Neuroscience Section Abstract Doc Link 8951884 Disease Relevance 0 Pain Relevance 1.99
These results supported our hypothesis that the mechanism of acute hypoxic adaptation involves an endogenous delta-1 opioid pathway and demonstrated that activation of a delta-1 receptor mimicked acute hypoxic adaptation induced by intermittent hypoxia.
Positive_regulation (activation) of delta-1 associated with hypoxia and opioid
4) Confidence 0.53 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113979 Disease Relevance 0.72 Pain Relevance 0.64
Spleen and thymus were chosen based on the requirement of Dll1 signaling for immunological parameters [26], [27].
Positive_regulation (requirement) of Dll1 in thymus
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.15 Pain Relevance 0
These results suggest that the effect of TAN-67 may result from the activation of central delta 1 opioid receptors, since the effect of TAN-67 was antagonized by NTI and BNTX, but not NTB.
Positive_regulation (activation) of delta 1 associated with opioid receptor
6) Confidence 0.49 Published 1995 Journal Life Sci. Section Abstract Doc Link 7603296 Disease Relevance 0 Pain Relevance 1.95
Using the mouse caudate-putamen, where delta-opioid receptor subtypes have been shown to regulate adenylyl cyclase activity, we show in this study that endogenous enkephalins inhibit enzyme activity through activation of delta 1- and delta 2-opioid receptors.
Positive_regulation (activation) of delta 1 in caudate-putamen associated with enkephalin and opioid receptor
7) Confidence 0.49 Published 1996 Journal Neuroscience Section Abstract Doc Link 8951884 Disease Relevance 0 Pain Relevance 0.80
Our results demonstrate that coadministration of TAN-67 with morphine enhances the morphine-induced place preference via activation of both delta 1 and delta 2 opioid receptors, suggesting that both delta 1 and delta 2 opioid receptors may modulate the morphine-induced rewarding effect.
Positive_regulation (activation) of delta 1 associated with opioid receptor and morphine
8) Confidence 0.49 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8858991 Disease Relevance 0 Pain Relevance 1.35
With the exception of delta1 receptors, the apparent role of these receptors to heroin dependence is consistent with their contribution to morphine dependence, indicating that there is substantial physiological commonality underlying dependence to both heroin and morphine.
Neg (exception) Positive_regulation (exception) of delta1 associated with addiction, opiate addiction and morphine
9) Confidence 0.46 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18343363 Disease Relevance 0.70 Pain Relevance 1.16
These results suggest that heroin activated supraspinal delta 1 receptors and MAM acted on supraspinal delta 2 receptors to produce antinociception in Swiss Webster mice.
Positive_regulation (activated) of delta 1 associated with antinociception
10) Confidence 0.45 Published 1994 Journal Life Sci. Section Abstract Doc Link 8046996 Disease Relevance 0 Pain Relevance 0.68
In the former two brain regions, alpha1C and alpha1D subunits of L-type HVCCs and alpha2/delta1 subunit increased, although decreases of alpha1B and alpha2/delta1 subunits were observed in the cerebellum.
Positive_regulation (increased) of delta1 in brain
11) Confidence 0.45 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17917366 Disease Relevance 0.17 Pain Relevance 0.70
These results suggest that stimulation of delta1- and delta2-opioid receptors produces amnesia, depending on the learning tasks used.
Positive_regulation (stimulation) of delta1 associated with opioid receptor and amnesia
12) Confidence 0.42 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9407996 Disease Relevance 0.27 Pain Relevance 0.48
Stimulation of delta1- and delta2-opioid receptors produces amnesia in mice.
Positive_regulation (Stimulation) of delta1 associated with enkephalin, opioid receptor and amnesia
13) Confidence 0.42 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9407996 Disease Relevance 0.10 Pain Relevance 0.68
However, lean mass, locomotor activity, and metabolized energy were increased in Dll1C413Y/+ compared to wild-type littermates.
Positive_regulation (increased) of Dll1C413Y associated with eae
14) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.08 Pain Relevance 0.09
Spleen and thymus were chosen based on the requirement of Dll1 signaling for immunological parameters [26], [27].
Positive_regulation (requirement) of Dll1 in Spleen
15) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.15 Pain Relevance 0

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