INT5006

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.11
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
blood 1
smooth muscle 1
liver 1
colon 1
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 6 98.28 Very High Very High Very High
Neuritis 1 95.52 Very High Very High Very High
antagonist 6 87.76 High High
sSRI 4 83.84 Quite High
Pain 8 81.56 Quite High
antidepressant 8 77.92 Quite High
cINOD 5 77.76 Quite High
cytokine 56 57.12 Quite High
Inflammation 118 50.00 Quite Low
Serotonin 1 48.80 Quite Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 4 99.68 Very High Very High Very High
Cancer 134 99.00 Very High Very High Very High
Disease 196 98.96 Very High Very High Very High
Epstein-barr Virus 4 98.50 Very High Very High Very High
Colorectal Cancer 5 97.20 Very High Very High Very High
Hyperplasia 2 96.96 Very High Very High Very High
Colon Cancer 7 96.28 Very High Very High Very High
Neuritis 2 95.52 Very High Very High Very High
Obesity 20 95.00 High High
Atherosclerosis 88 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using RT-PCR analyses, K20 mRNA can be detected in cell preparations from bone marrow and peripheral blood from some colorectal cancer patients, indicating the presence of disseminated tumor cells that maintain K20 expression, and a number of clinical studies have shown that this is correlated with a worse prognosis (Soeth et al. 1996; Funaki et al. 1998; Wyld et al. 1998; Koch et al. 2005; Katsumata et al. 2006; Friederichs et al. 2007).
Transcription (detected) of K20 in blood associated with colorectal cancer and cancer
1) Confidence 0.46 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.45 Pain Relevance 0
A CT-guided biopsy of liver showed lymphoma cells strongly positive for CD19 and CD20 stains: findings consistent with B-cell lymphoma.
Transcription (positive) of CD20 in liver associated with lymphatic system cancer
2) Confidence 0.42 Published 2002 Journal Leuk. Lymphoma Section Abstract Doc Link 12685847 Disease Relevance 0.70 Pain Relevance 0.08
From the first annotation to the D4 dopamine receptor (DRD4), the disease term (under Disease Complexes) is highlighted, indicating that protein–protein interaction information for this protein is available.
Transcription (information) of protein associated with dopamine receptor and disease
3) Confidence 0.07 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3013776 Disease Relevance 0.54 Pain Relevance 0.29
From the first annotation to the D4 dopamine receptor (DRD4), the disease term (under Disease Complexes) is highlighted, indicating that protein–protein interaction information for this protein is available.
Transcription (information) of protein associated with dopamine receptor and disease
4) Confidence 0.07 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3013776 Disease Relevance 0.53 Pain Relevance 0.27
After immortalization with EBV, at least 10 cell lines from each subject were tested for surface CD5 and CD20. mRNA expression was studied using cDNA probes for the six VH families as well as for CD5.
Transcription (expression) of CD20 associated with epstein-barr virus
5) Confidence 0.03 Published 1992 Journal Immunol. Lett. Section Abstract Doc Link 1283153 Disease Relevance 1.05 Pain Relevance 0.10
Protein concentration of the two samples was determined just before the IEF first-dimensional separation.
Transcription (concentration) of Protein
6) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2565687 Disease Relevance 0 Pain Relevance 0
PPARgamma messenger RNA (mRNA) and protein levels were assayed in colonic tumors and normal adjacent mucosa, as well as in a variety of human colon cancer cell lines.
Transcription (levels) of and protein in colon associated with cancer and colon cancer
7) Confidence 0.03 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9472692 Disease Relevance 0.96 Pain Relevance 0.22
For a more comprehensive depiction of the disease state, however, simultaneous examination of both the mRNA and protein levels of a molecule is vital as evidence suggests that correlation between the two can be poor [200,201].
Transcription (levels) of protein associated with disease
8) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.89 Pain Relevance 0
Ang II significantly increased the expression of IL-6 mRNA and protein in a dose-dependent manner (10(-10) to 10(-6) mol/L).
Transcription (expression) of protein
9) Confidence 0.01 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.49 Pain Relevance 0.07
Ang II significantly increases the expression of IL-6 mRNA and protein in vascular smooth muscle, in a dose-dependent manner.
Transcription (expression) of protein in smooth muscle
10) Confidence 0.01 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.51 Pain Relevance 0

General Comments

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