INT50061

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.77
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn3) extracellular region (Edn3) cellular_component (Edn3)
Anatomy Link Frequency
blood 1
outflow 1
Edn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 1 100.00 Very High Very High Very High
beta blocker 1 96.28 Very High Very High Very High
tetrodotoxin 5 93.20 High High
intrathecal 1 87.56 High High
Spinal cord 1 87.04 High High
antagonist 1 72.88 Quite High
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 3 100.00 Very High Very High Very High
Hemorrhage 1 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 88.80 High High
Cv Unclassified Under Development 2 61.48 Quite High
Obstructive Jaundice 1 52.24 Quite High
Sepsis 1 51.20 Quite High
Shock 1 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelin-3 levels were enhanced by hypothalamic stimulation and by hemorrhage-induced hypotension and reduced by nitroprusside-induced hypotension.
Negative_regulation (reduced) of Endothelin-3 associated with pressure volume 2 under development and cva
1) Confidence 0.58 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982458 Disease Relevance 0.39 Pain Relevance 0.14
Also pressor responses to ET-3 were abolished dose-dependently by i.c.v. pretreatment with propranolol at a dose of 1 mumol, nonselective beta-blocker and ICI 118551, beta 2-selective adrenoceptor blocker, but not by i.c.v. pretreatment with metoprolol, atenolol, beta 1-selective blocker, procaine and phentolamine.
Negative_regulation (abolished) of ET-3 associated with beta blocker
2) Confidence 0.43 Published 1995 Journal Life Sci. Section Abstract Doc Link 7603307 Disease Relevance 0.09 Pain Relevance 0.05
The lower dose of tezosentan also produced a decrease in the endothelin-3-induced gallbladder pressure (P < 0.02) but not in blood pressure, whereas the higher dose reduced the blood pressure with no further reduction in gallbladder pressure (P < 0.05).
Negative_regulation (decrease) of endothelin-3-induced in blood
3) Confidence 0.11 Published 2002 Journal J. Gastrointest. Surg. Section Abstract Doc Link 12399059 Disease Relevance 0.29 Pain Relevance 0.20
The response to VIC did not change after desensitization to either endothelin-1, endothelin-2 or endothelin-3, hence there is probably no cross-desensitization in evoked tritium outflow between VIC and endothelins.
Negative_regulation (desensitization) of endothelin-3 in outflow
4) Confidence 0.04 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7925592 Disease Relevance 0 Pain Relevance 0.27

General Comments

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