INT5007

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Context Info
Confidence 0.09
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.48
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHM) plasma membrane (IGHM)
Anatomy Link Frequency
CHO 2
bar 1
tube 1
B-cell 1
IGHM (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 224 100.00 Very High Very High Very High
Hippocampus 78 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
MU agonist 2 98.08 Very High Very High Very High
Immobilon 5 97.44 Very High Very High Very High
Neuritis 1 87.48 High High
Dynorphin 2 84.88 Quite High
agonist 4 75.00 Quite High
Kappa opioid receptor 2 75.00 Quite High
opioid receptor 2 74.40 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Disease 1 98.56 Very High Very High Very High
Immunization 21 96.84 Very High Very High Very High
Epstein-barr Virus 10 94.40 High High
Diabetes Mellitus-type I 6 91.56 High High
Neuritis 2 89.16 High High
Bacillus Anthracis Infection 115 89.12 High High
Cancer 3 76.48 Quite High
Anaerobic Bacterial Infections 12 48.92 Quite Low
Severe Combined Immunodeficiency 20 33.96 Quite Low
Death 20 29.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The VH families were represented by the VH3, VH1 and VH4.
Gene_expression (represented) of VH
1) Confidence 0.09 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC420254 Disease Relevance 0.09 Pain Relevance 0
Mixture of VH and VL cDNAs were synthesized and amplified in a same tube using One-Step RT-PCR Kit (Qiagen, Valencia, CA).
Gene_expression (synthesized) of VH in tube
2) Confidence 0.08 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC420254 Disease Relevance 0.30 Pain Relevance 0.03
As the PFC-NA and VH-NA connections are not reciprocal (both areas send heavy monosynaptic projections to the NA), the coherence data suggest that NA core follows VH activity during spatial exploration, but follows PFC activity during an operant task, even in the presence of similar spatial information.
Neg (not) Gene_expression (reciprocal) of VH associated with nucleus accumbens and hippocampus
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.89
The correlation between NA and VH neurons did not differ between exploration and the instrumental task (1.60±0.72 during exploration; 1.70±0.70 during bar press; n?
Gene_expression (neurons) of VH in bar associated with nucleus accumbens and hippocampus
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.41
After the final immunization, we cloned the variable heavy chain repertoire into a phage display vector using variable heavy domain framework 1 and 4 specific primers to capture VHH and VH genes since the latter have been shown to produce sdAb with favorable biophysical characteristics too [50].
Gene_expression (produce) of VH associated with immunization
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809108 Disease Relevance 0.10 Pain Relevance 0
CD5 and immunoglobulin VH gene expression in B-cell lines from patients with autoimmune diseases.
Gene_expression (expression) of immunoglobulin VH gene in B-cell associated with autoimmune disease
6) Confidence 0.01 Published 1992 Journal Immunol. Lett. Section Title Doc Link 1283153 Disease Relevance 1.00 Pain Relevance 0.09
In contrast, the efficacy of DA to stimulate and desensitize mu opioid receptors (muOR) stably expressed in CHO cells were comparable to those of other mu agonists.
Gene_expression (expressed) of muOR in CHO associated with mu agonist and mu opioid receptor
7) Confidence 0.00 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9488166 Disease Relevance 0 Pain Relevance 0.39
In contrast, the efficacy of DA to stimulate and desensitize mu opioid receptors (muOR) stably expressed in CHO cells were comparable to those of other mu agonists.
Gene_expression (desensitize) of muOR in CHO associated with mu agonist and mu opioid receptor
8) Confidence 0.00 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9488166 Disease Relevance 0 Pain Relevance 0.39

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