INT5008

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2010
Negated 0
Speculated 8
Reported most in Abstract
Documents 204
Total Number 212
Disease Relevance 80.35
Pain Relevance 125.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
nerve 16
sensory neurons 13
neurons 13
heart 11
sensory nerves 9
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 1631 100.00 Very High Very High Very High
Pain 1248 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1054 100.00 Very High Very High Very High
Inflammation 950 100.00 Very High Very High Very High
bradykinin 543 100.00 Very High Very High Very High
substance P 419 100.00 Very High Very High Very High
Neuropeptide 364 100.00 Very High Very High Very High
calcitonin gene related peptide 298 100.00 Very High Very High Very High
Neurotransmitter 107 100.00 Very High Very High Very High
Glutamate 59 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1203 100.00 Very High Very High Very High
INFLAMMATION 968 100.00 Very High Very High Very High
Nociception 940 100.00 Very High Very High Very High
Osteogenic Sarcomas 24 100.00 Very High Very High Very High
Neurogenic Inflammation 90 99.78 Very High Very High Very High
Ganglion Cysts 363 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 134 99.74 Very High Very High Very High
Targeted Disruption 731 99.60 Very High Very High Very High
Cancer 60 99.44 Very High Very High Very High
Congenital Anomalies 36 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Calcitonin gene-related peptide (CGRP) is contained in and released by small-diameter, nociceptive primary afferent sensory neurons.
Localization (released) of CGRP in sensory neurons associated with nociception and calcitonin gene-related peptide
1) Confidence 0.81 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17525595 Disease Relevance 0.34 Pain Relevance 0.50
BACKGROUND: Calcitonin gene-related peptide (CGRP) is contained in and released by small-diameter, nociceptive primary afferent sensory neurons.
Localization (released) of Calcitonin gene-related peptide in sensory neurons associated with nociception and calcitonin gene-related peptide
2) Confidence 0.81 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17525595 Disease Relevance 0.34 Pain Relevance 0.50
CGRP was able to release somatostatin from gastric D cells but its main effects on the stomach homeostasis rely on local vasodilator action during increased acid-back diffusion.
Localization (release) of CGRP in stomach associated with somatostatin and calcitonin gene-related peptide
3) Confidence 0.81 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19860701 Disease Relevance 0.78 Pain Relevance 0.65
Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive C-fiber and Adelta-fiber sensory nerves, has been suggested to play a beneficial role in myocardial ischemia-reperfusion (I/R) injury.
Localization (released) of CGRP in sensory nerves associated with c fibre, coronary artery disease, qutenza, ischemia, adelta, injury and calcitonin gene-related peptide
4) Confidence 0.81 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18192222 Disease Relevance 0.56 Pain Relevance 0.63
Our results suggest that CGRP released from sensory.
Localization (released) of CGRP associated with calcitonin gene-related peptide
5) Confidence 0.80 Published 1994 Journal Life Sci. Section Abstract Doc Link 8107527 Disease Relevance 0.39 Pain Relevance 0.69
The aim of the present study was to evaluate a simple and easily reproducible model for measuring stimulated CGRP release from cardial afferents.
Localization (release) of CGRP associated with calcitonin gene-related peptide
6) Confidence 0.80 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16413055 Disease Relevance 0.18 Pain Relevance 0.66
The results suggest that mouse heart immersion is more effective than coronary perfusion in measuring stimulated CGRP release from cardial afferents which are widely distributed in the epicardium but rare in deeper myocardial layers.
Localization (release) of CGRP in epicardium associated with calcitonin gene-related peptide
7) Confidence 0.80 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16413055 Disease Relevance 0.11 Pain Relevance 0.62
Immersion of hearts caused significantly more CGRP release than perfusion with same solutions.
Localization (release) of CGRP in hearts associated with calcitonin gene-related peptide
8) Confidence 0.80 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16413055 Disease Relevance 0.12 Pain Relevance 0.79
The results are discussed with respect to the potentially important vasodilatory and cardioprotective functions of CGRP released from activated epicardial afferents.
Localization (released) of CGRP associated with calcitonin gene-related peptide
9) Confidence 0.80 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16413055 Disease Relevance 0 Pain Relevance 0.52
Calcitonin gene-related peptide (CGRP), a potent vasodilator released from a subset of sensory Adelta- and C-fiber afferents, has been suggested to play a beneficial role in myocardial ischemia.
Localization (released) of CGRP associated with c fibre, coronary artery disease, ischemia, adelta and calcitonin gene-related peptide
10) Confidence 0.80 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16413055 Disease Relevance 0.18 Pain Relevance 0.49
These results suggest that spleen derived factor induced activation of vanilloid receptors and CGRP release may be contributing in the development of hyperalgesia in diabetic mice.
Localization (release) of CGRP in spleen associated with hyperalgesia and diabetes mellitus
11) Confidence 0.80 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18981706 Disease Relevance 1.51 Pain Relevance 0.78
Targeting of CGRP may be promising in controlling angiogenesis related to pathophysiological conditions.
Localization (Targeting) of CGRP associated with calcitonin gene-related peptide
12) Confidence 0.80 Published 2008 Journal Biomed. Pharmacother. Section Abstract Doc Link 18430544 Disease Relevance 0.80 Pain Relevance 0.64
Tibial but not femoral joint preparations from mice with collagenase-induced OA exhibited a significantly enhanced release upon BK stimulation compared to sham controls, while CAP-induced CGRP release did not reveal such difference.
Localization (release) of CGRP in joint
13) Confidence 0.80 Published 2004 Journal J. Rheumatol. Section Body Doc Link 15468368 Disease Relevance 0 Pain Relevance 0
Osteoarthritic mice exhibit enhanced prostaglandin E2 and unchanged calcitonin gene-related peptide release in a novel isolated knee joint model.
Localization (release) of calcitonin in knee joint associated with osteoarthritis and calcitonin gene-related peptide
14) Confidence 0.80 Published 2004 Journal J. Rheumatol. Section Title Doc Link 15468368 Disease Relevance 0.29 Pain Relevance 0.34
To assess joint nociceptor activation indirectly, we used a novel in vitro knee joint preparation and determined the release of calcitonin gene-related peptide (CGRP) and prostaglandin E2 (PGE2) in osteoarthritic mice.
Spec (determined) Localization (release) of calcitonin in joint associated with nociceptor, osteoarthritis and calcitonin gene-related peptide
15) Confidence 0.80 Published 2004 Journal J. Rheumatol. Section Abstract Doc Link 15468368 Disease Relevance 0.36 Pain Relevance 0.33
To assess joint nociceptor activation indirectly, we used a novel in vitro knee joint preparation and determined the release of calcitonin gene-related peptide (CGRP) and prostaglandin E2 (PGE2) in osteoarthritic mice.
Spec (determined) Localization (release) of CGRP in joint associated with nociceptor, osteoarthritis and calcitonin gene-related peptide
16) Confidence 0.80 Published 2004 Journal J. Rheumatol. Section Abstract Doc Link 15468368 Disease Relevance 0.36 Pain Relevance 0.33
CONCLUSION: Basal and evoked PGE2 release from knee joint preparations rose while osteoarthritic alterations developed, whereas CGRP release remained unaltered.
Localization (release) of CGRP in PGE2
17) Confidence 0.80 Published 2004 Journal J. Rheumatol. Section Body Doc Link 15468368 Disease Relevance 0 Pain Relevance 0
In the second, neurochemical approach, the heat-induced cutaneous release of calcitonin gene-related peptide (CGRP) was investigated to gain comparative data on the neurosecretory (vasodilatory) functions of the primary afferent neurons.
Localization (release) of CGRP in afferent neurons associated with calcitonin gene-related peptide
18) Confidence 0.80 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12045234 Disease Relevance 0.36 Pain Relevance 0.54
In the second, neurochemical approach, the heat-induced cutaneous release of calcitonin gene-related peptide (CGRP) was investigated to gain comparative data on the neurosecretory (vasodilatory) functions of the primary afferent neurons.
Localization (release) of calcitonin gene-related peptide in afferent neurons associated with calcitonin gene-related peptide
19) Confidence 0.80 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12045234 Disease Relevance 0.36 Pain Relevance 0.54
The substantial increase of CGRP release evoked by noxious heat (47 degrees C) was diminished under muscarine by >50% in the WT and M4 KO animals but remained unaltered in the M2 KO mice.
Localization (release) of CGRP associated with calcitonin gene-related peptide
20) Confidence 0.80 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12045234 Disease Relevance 0.36 Pain Relevance 0.54

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