INT50080

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 29.61
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
plasma 3
leukocyte 2
macrophages 1
kidney 1
neuronal 1
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 70 99.10 Very High Very High Very High
drug abuse 1 98.64 Very High Very High Very High
tail-flick 2 97.32 Very High Very High Very High
Antinociceptive 4 97.12 Very High Very High Very High
Pain 21 97.08 Very High Very High Very High
cINOD 14 96.96 Very High Very High Very High
epidural 2 93.16 High High
analgesia 7 92.00 High High
Morphine 12 87.84 High High
Inflammatory response 6 80.56 Quite High
Disease Link Frequency Relevance Heat
Disease 715 100.00 Very High Very High Very High
Cognitive Disorder 310 100.00 Very High Very High Very High
Stroke 209 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 173 100.00 Very High Very High Very High
Diabetes Mellitus 152 100.00 Very High Very High Very High
Kuru 130 100.00 Very High Very High Very High
Hypertension 123 100.00 Very High Very High Very High
Heart Disease 85 100.00 Very High Very High Very High
Aging 40 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 109 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the number of patients in our study was necessarily small, there was no evidence of association of kuru with PRNP haplotype, HLA DQ7, ApoE or PRND alleles (Collinge et al. 2006).
ApoE Neg (no) Binding (association) of associated with kuru
1) Confidence 0.45 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581654 Disease Relevance 0.81 Pain Relevance 0
APOE genotyping will be performed at baseline testing to adjust for APOE genotype in the final analysis and to investigate whether there is an interaction between APOE genotype and the benefits of PA influencing the primary and secondary outcomes.
APOE Binding (interaction) of
2) Confidence 0.40 Published 2010 Journal Trials Section Body Doc Link PMC3016362 Disease Relevance 0 Pain Relevance 0
In a series of secondary analyses we examined the associations between vascular conditions, diabetes and dementia separately by treatment status and examined interactions with APOE genotype.
APOE Spec (examined) Binding (interactions) of associated with dementia and diabetes mellitus
3) Confidence 0.38 Published 2010 Journal Alzheimers Res Ther Section Body Doc Link PMC2919699 Disease Relevance 1.58 Pain Relevance 0
Apart from age, the APOE epsilon 4 allele represents the most important risk factor in sporadic Alzheimer's disease (AD).
APOE Binding (represents) of associated with disease
4) Confidence 0.37 Published 2001 Journal Biochem. Soc. Symp. Section Abstract Doc Link 11447828 Disease Relevance 0.44 Pain Relevance 0.12
Apolipoprotein E was chemically bound via linkers to loperamide-loaded HSA-NP.
Apolipoprotein E Binding (bound) of associated with disorder of lipid metabolism
5) Confidence 0.37 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16554356 Disease Relevance 0.51 Pain Relevance 0.14
AD, Alzheimer's disease; APOE, apolipoprotein E; CAMCOG, Cambridge Cognitive Examination; CERAD, The Consortium to Establish a Registry for Alzheimer's Disease; CI, confidence interval; HLA, human leukocyte antigen; NINCDS-ADRDA, National Institute of Neurological, Communicative Diseases and Stroke-Alzheimer's Disease and Related Diseases Association; NK, natural killer; OPTIMA, Oxford Project to Investigate Memory and Ageing; PCR, polymerase chain reaction; SSP, sequence-specific primers; TNF, tumour necrosis factor

Competing interests

APOE Binding (primers) of in leukocyte associated with necrosis, cognitive disorder, aging, cancer, stroke, disease and disorder of lipid metabolism
6) Confidence 0.36 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 1.39 Pain Relevance 0
Genotyping for APOE alleles and IL-1A(-889) allele 2 was performed by PCR-based amplification followed by restrictive endonuclease digestion.
APOE Binding (Genotyping) of
7) Confidence 0.36 Published 2000 Journal Neurology Section Body Doc Link 10953177 Disease Relevance 0 Pain Relevance 0
Recent data suggest a genetic predisposition for cognitive decline after cardiac surgery in patients possessing the apolipoprotein E epsilon-4 allele, known to be associated with late-onset and sporadic forms of Alzheimer's disease.
apolipoprotein E Binding (associated) of associated with cognitive disorder, genetic predisposition to disease, disease and disorder of lipid metabolism
8) Confidence 0.36 Published 1995 Journal Ann. Thorac. Surg. Section Abstract Doc Link 7733762 Disease Relevance 0.82 Pain Relevance 0.12
In a broad epidemiological study a reduction of the risk of AD in individuals with the Apo E-?
Apo E Binding (individuals) of associated with disease
9) Confidence 0.36 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.54 Pain Relevance 0.66
Regenerative sprouting was significantly associated with the baseline intraepidermal nerve fiber density (p < 0.001) but not with HIV viral load, HIV duration, CD4 cell count, or ApoE epsilon4 status.
ApoE Neg (not) Binding (associated) of in nerve
10) Confidence 0.36 Published 2007 Journal Neurology Section Body Doc Link 17438214 Disease Relevance 0 Pain Relevance 0
The results suggest that for individuals with no apolipoprotein E epsilon 4 alleles the presence of either DR1, 2 or 3 antigens is associated with a significantly increased risk for development of late-onset AD.
apolipoprotein E Binding (individuals) of associated with disease and disorder of lipid metabolism
11) Confidence 0.36 Published 1997 Journal Neuroreport Section Abstract Doc Link 9172155 Disease Relevance 0.54 Pain Relevance 0.11
4 carriers as compared to ApoE-?
ApoE Binding (compared) of
12) Confidence 0.36 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 1.75 Pain Relevance 0.08
They found no evidence for an interaction between the IL-1A and the apoE epsilon 4 polymorphisms (carriers and homozygotes), age, or gender with regard to conferred risk.
apoE Neg (no) Binding (interaction) of
13) Confidence 0.36 Published 2000 Journal Neurology Section Body Doc Link 10953177 Disease Relevance 0 Pain Relevance 0
The published data remain inconsistent on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP), mainly because of low statistical power of previous studies.
APOE Binding (association) of in plasma associated with disorder of lipid metabolism
14) Confidence 0.36 Published 2010 Journal Human Immunology Section Abstract Doc Link PMC2837141 Disease Relevance 0.10 Pain Relevance 0.04
This result thus contradicts our previous suggestion [9] of an interaction with APOE4.
APOE4 Binding (interaction) of
15) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.08 Pain Relevance 0
In the only study to date to examine whether there is a genetic predisposition to ICU delirium in some patients, Ely and coworkers [38] evaluated the association between apolipoprotein E (APOE) genotype and duration of delirium among 53 mechanically ventilated medical ICU patients.
APOE Binding (association) of associated with delirium, genetic predisposition to disease and disorder of lipid metabolism
16) Confidence 0.35 Published 2008 Journal Crit Care Section Body Doc Link PMC2391269 Disease Relevance 1.86 Pain Relevance 0.46
We found that HIV-infected individuals with the E4 allele of Apolipoprotein E (ApoE) or history of intravenous drug abuse had increased oxidative stress in the CNS.
Apolipoprotein E Binding (individuals) of associated with stress, intravenous substance abuse, drug abuse, acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism
17) Confidence 0.34 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16697650 Disease Relevance 1.19 Pain Relevance 0.33
First, the biologic mechanisms responsible for the association between APOE genotype and CVD remain unclear; examining whether associations between APOE and potential cardiovascular risk factors (such as CRP) mirror the association of APOE with CVD is, therefore, helpful in elucidating the causal pathway.
APOE Binding (association) of associated with cardiovascular disease
18) Confidence 0.33 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.71 Pain Relevance 0.09
Previous case reports have variably suggested links between age at diagnosis, onset of treatment with low fat diet and vitamin replacement therapy, type of MTP mutation and APOE genotype with the long-term outcome of patients with ABL.
APOE Binding (genotype) of in fat
19) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.34 Pain Relevance 0
Also, regarding a possible relationship between APOE genotype and clinical progression of disease, a recent meta-analysis identified a linear relationship of APOE genotype with plasma LDL cholesterol [36].
APOE Binding (genotype) of in plasma associated with disease
20) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.24 Pain Relevance 0

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