INT50081

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
plasma 2
groove 2
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 50.00 Quite Low
Inflammation 2 10.00 Low Low
Paracetamol 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 2 92.08 High High
Disorder Of Lipid Metabolism 2 90.52 High High
Low Back Pain 1 50.00 Quite Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Wound Healing 15 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is already known that the LBD of liganded TR binds a single LxxLL motif of a coactivator through the hydrophobic groove of the liganded-LBD [Nolte et al., 1998], with the enhanced activation suggesting a conformational change in NCoA6(NRC) leading to enhanced AD2 activity.
Positive_regulation (leading) of Positive_regulation (leading) of AD2 in groove
1) Confidence 0.49 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
SUMMARY OF BACKGROUND DATA: A twofold to fivefold increase in human plasma apolipoprotein E may be a physiologic response to PND as a 250-fold local increase in apolipoprotein E was reported in experimental PND studies in mammals.
Positive_regulation (response) of Positive_regulation (increase) of apolipoprotein E in plasma
2) Confidence 0.43 Published 1995 Journal Spine Section Body Doc Link 7604328 Disease Relevance 0.18 Pain Relevance 0

General Comments

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