INT50084

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Context Info
Confidence 0.03
First Reported 1995
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.11
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC12A1) plasma membrane (SLC12A1) transmembrane transport (SLC12A1)
Anatomy Link Frequency
plasma 3
brain 1
SLC12A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 99.52 Very High Very High Very High
qutenza 4 97.28 Very High Very High Very High
Pain 4 96.64 Very High Very High Very High
Trigeminal ganglion neurons 1 88.16 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 100.00 Very High Very High Very High
Nervous System Injury 6 99.88 Very High Very High Very High
Low Back Pain 3 96.92 Very High Very High Very High
Ganglion Cysts 1 87.28 High High
INFLAMMATION 1 81.84 Quite High
Pain 1 81.16 Quite High
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: A statistically significant (P < 0.005) elevation of the plasma apolipoprotein E variant was found in patients with chronic lumbar pain.
Positive_regulation (elevation) of variant in plasma
1) Confidence 0.03 Published 1995 Journal Spine Section Body Doc Link 7604328 Disease Relevance 0.14 Pain Relevance 0
Preliminary study of an increase of a plasma apolipoprotein E variant associated with peripheral nerve damage.
Positive_regulation (increase) of variant in plasma associated with nervous system injury, inflammation and disorder of lipid metabolism
2) Confidence 0.03 Published 1995 Journal Spine Section Title Doc Link 7604328 Disease Relevance 0.30 Pain Relevance 0.15
By probing human and rat brain cDNA libraries to identify TRPV subunits, we identified a novel human TRPV1 RNA splice variant, TRPV1b, which forms functional ion channels that are activated by temperature (threshold, approximately 47 degrees C), but not by capsaicin or protons.
Neg (not) Positive_regulation (activated) of variant in brain associated with qutenza
3) Confidence 0.02 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15644492 Disease Relevance 0.25 Pain Relevance 0.35
STUDY DESIGN: This two-dimensional gel electrophoretic study analyzed the plasma of six groups of patients to determine the association of an elevated apolipoprotein E variant with peripheral nerve damage (PND).
Positive_regulation (elevated) of variant in plasma associated with nervous system injury and disorder of lipid metabolism
4) Confidence 0.02 Published 1995 Journal Spine Section Abstract Doc Link 7604328 Disease Relevance 0.42 Pain Relevance 0.07

General Comments

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