INT5010

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2011
Negated 7
Speculated 8
Reported most in Abstract
Documents 197
Total Number 205
Disease Relevance 85.76
Pain Relevance 118.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
neurons 22
sensory neurons 9
nociceptors 9
spinal cord 8
IB4 7
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1242 100.00 Very High Very High Very High
nociceptor 940 100.00 Very High Very High Very High
Pain 641 100.00 Very High Very High Very High
qutenza 478 100.00 Very High Very High Very High
Spinal cord 442 100.00 Very High Very High Very High
Inflammation 428 100.00 Very High Very High Very High
substance P 422 100.00 Very High Very High Very High
Neuropeptide 398 100.00 Very High Very High Very High
Nerve growth factor 345 100.00 Very High Very High Very High
dorsal root ganglion 309 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1188 100.00 Very High Very High Very High
Pain 633 100.00 Very High Very High Very High
Nociception 339 100.00 Very High Very High Very High
Neurogenic Inflammation 30 100.00 Very High Very High Very High
Hypothermia 56 99.96 Very High Very High Very High
Ulcers 26 99.92 Very High Very High Very High
Targeted Disruption 813 99.68 Very High Very High Very High
Cancer 505 99.64 Very High Very High Very High
Stress 27 99.64 Very High Very High Very High
INFLAMMATION 400 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, CGRP expression was up-regulated in the peripheral nerves of the upper dermis and lower epidermis.
Gene_expression (expression) of CGRP in upper associated with calcitonin gene-related peptide
1) Confidence 0.78 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.27 Pain Relevance 0.45
Intradermal injections of capsaicin prior to UVB-irradiation inhibited the UVB-induced CGRP expression, BrdU labeling in basal keratinocytes and epidermal thickening.
Gene_expression (expression) of CGRP in keratinocytes associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.78 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.26 Pain Relevance 0.55
Repeated ultraviolet (UV) irradiations have been shown to induce keratinocyte proliferation with acanthosis, stimulate the cutaneous nerve proliferation, and increase the synthesis of calcitonin gene-related peptide (CGRP).
Gene_expression (synthesis) of calcitonin gene-related peptide in keratinocyte associated with acanthosis and calcitonin gene-related peptide
3) Confidence 0.78 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.25 Pain Relevance 0.35
Increased synthesis of calcitonin gene-related peptide stimulates keratinocyte proliferation in murine UVB-irradiated skin.
Gene_expression (synthesis) of calcitonin gene-related peptide in skin associated with qutenza and calcitonin gene-related peptide
4) Confidence 0.78 Published 2002 Journal J. Dermatol. Sci. Section Title Doc Link 11858952 Disease Relevance 0.24 Pain Relevance 0.57
Repeated ultraviolet (UV) irradiations have been shown to induce keratinocyte proliferation with acanthosis, stimulate the cutaneous nerve proliferation, and increase the synthesis of calcitonin gene-related peptide (CGRP).
Gene_expression (synthesis) of CGRP in keratinocyte associated with acanthosis and calcitonin gene-related peptide
5) Confidence 0.78 Published 2002 Journal J. Dermatol. Sci. Section Abstract Doc Link 11858952 Disease Relevance 0.25 Pain Relevance 0.35
Moreover, these data suggest that adenoviral gene transfer of CGRP to the lung results in expression of the gene product in non-neural tissue.
Gene_expression (transfer) of CGRP in lung associated with calcitonin gene-related peptide
6) Confidence 0.78 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.60 Pain Relevance 0.40
Following exposure to hypoxia, a subgroup of mice were treated with capsaicin, which did not significantly alter CGRP expression in the mouse lung.
Gene_expression (expression) of CGRP in lung associated with qutenza, hypoxia and calcitonin gene-related peptide
7) Confidence 0.78 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.66 Pain Relevance 0.49
The increase in pulmonary arterial pressure (PAP), PVR, right ventricular mass, and pulmonary vascular remodeling in response to chronic hypoxia was attenuated in animals overexpressing CGRP, whereas systemic arterial pressure was not altered.
Gene_expression (overexpressing) of CGRP associated with hypoxia and calcitonin gene-related peptide
8) Confidence 0.78 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.67 Pain Relevance 0.48
These data show that in vivo transfer of the CGRP gene to the lung attenuates the increase in PVR, right ventricular mass, and pulmonary vascular remodeling in chronically hypoxic mice with little effect on the systemic circulation.
Gene_expression (transfer) of CGRP gene in lung associated with hypoxia and calcitonin gene-related peptide
9) Confidence 0.78 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.66 Pain Relevance 0.49
Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts and is endowed with important systemic physiological effects.
Gene_expression (produced) of CGRP associated with calcitonin gene-related peptide
10) Confidence 0.78 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19860701 Disease Relevance 0.08 Pain Relevance 0.36
These results suggest that: (1) early expression of the CGRP phenotype is regulated in a cell-autonomous way in developing mouse DRG neurons in vitro; and (2) the RTX-induced increase in CGRP biosynthesis is most likely the result of activating the capsaicin/RTX receptor rather than directly activating the protein kinase C (PKC) pathway in vitro.
Gene_expression (expression) of CGRP in neurons associated with dorsal root ganglion, kinase c, qutenza and calcitonin gene-related peptide
11) Confidence 0.78 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7955356 Disease Relevance 0.32 Pain Relevance 0.88
The calcitonin gene-related peptide (CGRP) phenotype is expressed early and up-regulated by resiniferatoxin (RTX) in mouse sensory neurons.
Gene_expression (expressed) of CGRP in sensory neurons associated with qutenza and calcitonin gene-related peptide
12) Confidence 0.78 Published 1994 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 7955356 Disease Relevance 0.31 Pain Relevance 0.84
Expression of pain-related host signals in the spinal cord, such as calcitonin gene-related peptide (CGRP), substance P, and c-fos, was investigated with immunohistochemical staining.
Spec (investigated) Gene_expression (Expression) of calcitonin gene-related peptide in spinal cord associated with pain, substance p, calcitonin gene-related peptide and spinal cord
13) Confidence 0.78 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15659796 Disease Relevance 1.53 Pain Relevance 1.37
Expression of pain-related host signals in the spinal cord, such as calcitonin gene-related peptide (CGRP), substance P, and c-fos, was investigated with immunohistochemical staining.
Spec (investigated) Gene_expression (Expression) of CGRP in spinal cord associated with pain, substance p, calcitonin gene-related peptide and spinal cord
14) Confidence 0.78 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15659796 Disease Relevance 1.53 Pain Relevance 1.38
After irradiation of tumors, significant decreases in the expression of CGRP were shown in the spinal cord, whereas neither substance P nor c-fos showed any alteration.
Gene_expression (expression) of CGRP in spinal cord associated with cancer, substance p, spinal cord and calcitonin gene-related peptide
15) Confidence 0.78 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15659796 Disease Relevance 1.44 Pain Relevance 1.41
It was found that calcitonin gene-related peptide (CGRP) (i.t.) also produced hypothermia.
Gene_expression (produced) of CGRP associated with hypothermia and calcitonin gene-related peptide
16) Confidence 0.78 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8371146 Disease Relevance 0.37 Pain Relevance 0.47
Importantly, intra-tumor injection of a CGRP1 receptor antagonist (CGRP 8-37) partially blocked the tumor-associated mechanical hyperalgesia, indicating that local production of CGRP may contribute to tumor-induced nociception through a receptor-mediated process.
Gene_expression (production) of CGRP associated with nociception, calcitonin gene related peptide, hyperalgesia, cancer and antagonist
17) Confidence 0.78 Published 2005 Journal Pain Section Abstract Doc Link 15836973 Disease Relevance 1.86 Pain Relevance 0.78
Immunocytochemical analysis using the above-mentioned antibodies yielded three different populations of neurons in both dorsal root and nodose ganglia, namely CGRP/--, SP/--, and CGRP/SP-expressing neurons.
Gene_expression (expressing) of CGRP in neurons associated with substance p and calcitonin gene-related peptide
18) Confidence 0.76 Published 2003 Journal Histochem. Cell Biol. Section Abstract Doc Link 12768286 Disease Relevance 0.24 Pain Relevance 0.95
Neurochemical characterization of extrinsic primary afferent neurons (EPANs) in normal and capsaicin-treated mice, revealed that CGRP and VR1, but not SP, were expressed in extrinsic afferents.
Neg (not) Gene_expression (expressed) of CGRP in afferent neurons associated with qutenza, substance p and calcitonin gene-related peptide
19) Confidence 0.76 Published 2003 Journal Histochem. Cell Biol. Section Abstract Doc Link 12768286 Disease Relevance 0.23 Pain Relevance 0.83
Spinal cords were processed immunohistochemically at the injury/transplantation site for characterization of NSC survival and differentiation; and at the cervicothoracic level for calcitonin gene-related peptide (CGRP), a neuropeptide expressed in dorsal horn nocioceptive neurons, and growth-associated protein-43 (GAP43), a marker of neuronal sprouting.
Gene_expression (expressed) of CGRP in neuronal associated with injury, dorsal horn, neuropeptide and calcitonin gene-related peptide
20) Confidence 0.76 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16839548 Disease Relevance 0.79 Pain Relevance 0.80

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