INT50106

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1994
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.15
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
brain 4
pancreas 2
vesicle 2
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 6 100.00 Very High Very High Very High
Abeta 2 100.00 Very High Very High Very High
sSRI 96 99.68 Very High Very High Very High
bradykinin 3 99.24 Very High Very High Very High
Chronic pancreatitis 3 97.92 Very High Very High Very High
Neuropeptide 3 96.64 Very High Very High Very High
tetrodotoxin 6 96.16 Very High Very High Very High
Kinase C 3 94.96 High High
Opioid 1 94.68 High High
Enkephalin 1 94.40 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 23 100.00 Very High Very High Very High
Pancreatitis 23 97.92 Very High Very High Very High
Disease 115 94.36 High High
Neurodegenerative Disease 15 93.36 High High
Apoptosis 5 60.64 Quite High
Cognitive Disorder 62 50.00 Quite Low
Pain 3 50.00 Quite Low
Amyloid Plaque 5 18.04 Low Low
Frailty 4 11.84 Low Low
Depression 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study showed that cathepsin B is abundantly present in the secretory compartment of the healthy human pancreas and is secreted together with trypsinogen and active trypsin into the pancreatic juice of patients with chronic pancreatitis [8].
Positive_regulation (active) of Localization (secreted) of cathepsin B in pancreas associated with chronic pancreatitis
1) Confidence 0.33 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.54 Pain Relevance 0.15
Other receptors that stimulate APPs secretion include those for bradykinin, vasopressin, and interleukin-1 receptors.
Positive_regulation (stimulate) of Localization (secretion) of APPs associated with bradykinin
2) Confidence 0.15 Published 1994 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 7897393 Disease Relevance 0.37 Pain Relevance 0.25
A similar control mechanism is present in rat brain tissue slices, in which the release of both APPs and endogenous neurotransmitters is increased by electrical depolarization.
Positive_regulation (increased) of Localization (release) of APPs in brain associated with neurotransmitter
3) Confidence 0.15 Published 1994 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 7897393 Disease Relevance 0.34 Pain Relevance 0.27
Secretion of APPs, a secreted proteolytic derivative that is cleaved within the beta A4 domain of APP, is increased many-fold by the activation of cell-surface receptors, like the muscarinic m1 and m3 receptor subtypes, which are coupled to protein kinase C.
Spec (like) Positive_regulation (increased) of Localization (Secretion) of APPs associated with kinase c
4) Confidence 0.15 Published 1994 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 7897393 Disease Relevance 0.44 Pain Relevance 0.08
RESULT: The relative risks for affirming the sue MD statement relative to the healthy community sample for various groups were as follows in order of ascending risk: APPs in rehabilitation; nonhealthy community members; rehabilitation patients in general; rehabilitation patients without pain; CPPs in rehabilitation; and with the highest risk being rehabilitation patients with worker's compensation litigation.
Positive_regulation (risks) of Localization (rehabilitation) of APPs
5) Confidence 0.13 Published 2008 Journal Pain Med Section Body Doc Link 18657217 Disease Relevance 0 Pain Relevance 0
Electrical field stimulation significantly increased the release of APPs within 50 min.
Positive_regulation (increased) of Localization (release) of APPs
6) Confidence 0.10 Published 1995 Journal Neuroreport Section Abstract Doc Link 7605915 Disease Relevance 0.16 Pain Relevance 0.09
Cholinesterase inhibitors increase secretion of APPs in rat brain cortex.
Positive_regulation (increase) of Localization (secretion) of APPs in brain
7) Confidence 0.10 Published 1995 Journal Neuroreport Section Title Doc Link 7605915 Disease Relevance 0.16 Pain Relevance 0.07
Electrical field stimulation significantly increased the release of APPs within 50 min.
Positive_regulation (increased) of Localization (release) of APPs
8) Confidence 0.09 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8624119 Disease Relevance 0.16 Pain Relevance 0.09
Unlike the studies above, SSRI administration enhances secretion of entire APPs and does not specifically alter expression of the APP ectodomain segment.
Positive_regulation (enhances) of Localization (secretion) of APPs associated with ssri
9) Confidence 0.02 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 0.50 Pain Relevance 0.27
Furthermore, new results using these strategies have identified secretory vesicle cathepsin B for the production of beta-amyloid (Abeta) in the major regulated secretory pathway that provides activity-dependent secretion of Abeta peptides, which accumulate in AD. 3.
Positive_regulation (accumulate) of Localization (secretion) of cathepsin B in vesicle associated with alzheimer's dementia and abeta
10) Confidence 0.02 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16724274 Disease Relevance 0.50 Pain Relevance 0.42

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox