INT5011

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 9.88
Pain Relevance 11.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
neurons 3
DRG 3
dorsal horn 2
DA neurons 1
hepatocytes 1
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 10 100.00 Very High Very High Very High
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
Inflammation 40 99.98 Very High Very High Very High
dorsal root ganglion 16 99.84 Very High Very High Very High
intrathecal 6 99.84 Very High Very High Very High
Antinociceptive 13 99.78 Very High Very High Very High
Dorsal horn 11 99.56 Very High Very High Very High
Locus ceruleus 11 98.88 Very High Very High Very High
narcan 2 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.98 Very High Very High Very High
Ganglion Cysts 19 99.84 Very High Very High Very High
Status Epilepticus 1 99.68 Very High Very High Very High
Thyroid Disease 16 99.62 Very High Very High Very High
Hypertension 2 99.44 Very High Very High Very High
Aids-related Complex 8 99.20 Very High Very High Very High
Schizophrenia 220 96.36 Very High Very High Very High
Nociception 9 92.32 High High
Neuropathic Pain 7 88.60 High High
Bordatella Infection 2 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antinociceptive effect of galanin was partly inhibited by intrathecal injection of naloxone.
Negative_regulation (inhibited) of galanin associated with narcan, antinociceptive and intrathecal
1) Confidence 0.57 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 16214241 Disease Relevance 0.58 Pain Relevance 1.25
During the recovery phase there may be a reduction in galanin receptors, which may impair the action of endogenous and exogenous galanin.
Negative_regulation (reduction) of galanin
2) Confidence 0.57 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639276 Disease Relevance 0.47 Pain Relevance 0.55
The inhibitory effect of galanin was concentration dependent, with an EC50 value of 5.8 +/- 1.9 nM.
Negative_regulation (effect) of galanin
3) Confidence 0.57 Published 1991 Journal Peptides Section Abstract Doc Link 1724798 Disease Relevance 0 Pain Relevance 0.30
After peripheral tissue inflammation galanin-R1 receptor mRNA levels decrease and galanin-R2 receptor mRNA levels increase.
Negative_regulation (decrease) of galanin associated with inflammation
4) Confidence 0.53 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928186 Disease Relevance 0.90 Pain Relevance 0.92
Galanin-R1 receptor mRNA is downregulated in DRG neurons after axotomy, and a small decrease in galanin-R2 receptor mRNA levels can also be seen.
Negative_regulation (decrease) of galanin in DRG associated with dorsal root ganglion
5) Confidence 0.53 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928186 Disease Relevance 0.89 Pain Relevance 0.88
Galanin-R1 receptor mRNA is downregulated in DRG neurons after axotomy, and a small decrease in galanin-R2 receptor mRNA levels can also be seen.
Negative_regulation (downregulated) of Galanin in DRG associated with dorsal root ganglion
6) Confidence 0.53 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928186 Disease Relevance 0.89 Pain Relevance 0.79
The present data demonstrate that galanin is an inhibitor of basal and stimulated gastrin secretion and has to be considered as an inhibitory neurotransmitter which could participate in the regulation of gastric G-cell function.
Negative_regulation (inhibitor) of galanin associated with neurotransmitter
7) Confidence 0.47 Published 1988 Journal Life Sci. Section Abstract Doc Link 2453773 Disease Relevance 0 Pain Relevance 0.24
The inhibitory action of galanin on gastrin secretion was also present during the infusion of tetrodotoxin suggesting that this effect is not mediated via neural pathways.
Negative_regulation (action) of galanin in neural associated with tetrodotoxin
8) Confidence 0.47 Published 1988 Journal Life Sci. Section Abstract Doc Link 2453773 Disease Relevance 0 Pain Relevance 0.24
Local denervation immediately proximal to the sphincter markedly reduced the numbers of VIP/NOS/galanin- and VIP/NOS/galanin/PACAP +/- NPY-containing fibres within the sphincter suggesting an origin of these fibres in myenteric ganglia in the antral region; denervation at the level of the oxyntic-pyloric border had no effect.
Negative_regulation (numbers) of galanin in ganglia
9) Confidence 0.42 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12132647 Disease Relevance 0 Pain Relevance 0.94
The antinociceptive effect of galanin was blocked by following intra-ARC injection of galantide, a putative galanin receptor antagonist, suggesting that the antinociceptive effect of galanin is mediated by galanin receptors.
Negative_regulation (blocked) of galanin in ARC associated with aids-related complex, antagonist and antinociceptive
10) Confidence 0.41 Published 2003 Journal Pain Section Abstract Doc Link 14581121 Disease Relevance 1.01 Pain Relevance 0.53
In the ipsilateral L1/L2 dorsal horn, CGRP and tachykinin, but not galanin, immunoreactivity was reduced.
Negative_regulation (reduced) of galanin in dorsal horn associated with dorsal horn
11) Confidence 0.41 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.15 Pain Relevance 0.25
The antinociceptive effect of galanin was blocked by a subsequent intra-TM injection of galantide, a putative galanin receptor antagonist, suggesting that the antinociceptive effect of galanin is mediated by galanin receptors.
Negative_regulation (blocked) of galanin associated with antagonist and antinociceptive
12) Confidence 0.41 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15352218 Disease Relevance 0.39 Pain Relevance 0.51
Hypothyroidism did not influence GAL mRNA in the anterior PVN, perifornical area or in the arcuate nucleus, whereas a decrease in GAL mRNA was observed in the dorsomedial nucleus.
Negative_regulation (decrease) of GAL in nucleus associated with thyroid disease
13) Confidence 0.41 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1283206 Disease Relevance 0.40 Pain Relevance 0.22
Hypothyroidism caused a dramatic decrease in GAL mRNA in parvo- and magnocellular PVN neurons both 28 and 50 days after thyroid ablation, whereas no effect was seen in VP mRNA, the main peptide hormone coexisting with GAL.
Negative_regulation (decrease) of GAL in neurons associated with thyroid disease
14) Confidence 0.41 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1283206 Disease Relevance 0.45 Pain Relevance 0.17
From these findings we conclude that (a) galanin exerts an inhibitory effect on the internal anal sphincter by activating galanin receptors both at the intramural inhibitory neurons and at the internal anal sphincter smooth muscle and that the N-terminal portion of galanin may be responsible for these actions; (b) the contractile action of galanin is produced by its action on the smooth muscle; and (c) the actions of galanin on the gastrointestinal tract are tissue specific.
Negative_regulation (portion) of galanin in terminal portion
15) Confidence 0.41 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1704327 Disease Relevance 0 Pain Relevance 0.16
However, instead of protecting GalN-induced depletion of UDP-glucuronic acid in hepatocytes, the flavone itself reduced the nucleotide content very rapidly compared to GalN, the later exerted time dependent effect.
Negative_regulation (reduced) of GalN in hepatocytes
16) Confidence 0.41 Published 1997 Journal Indian J. Exp. Biol. Section Abstract Doc Link 9357165 Disease Relevance 0.30 Pain Relevance 0.37
The inhibitory effect of galanin was antagonized by galantide and produced self-desensitization.
Negative_regulation (effect) of galanin
17) Confidence 0.37 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549619 Disease Relevance 0 Pain Relevance 0.14
Using the antibody microprobe technique to study the localized sites of ir-galanin release in vivo, we found that high intensity electrical stimulation of the injured nerve resulted in a further increase in ir-galanin release in the superficial dorsal horn, with no significant persistence of ir-galanin after release.
Neg (no) Negative_regulation (persistence) of ir-galanin in dorsal horn associated with dorsal horn
18) Confidence 0.37 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9861137 Disease Relevance 0.25 Pain Relevance 0.47
These results may suggest an indirect (insulin-mediated) inhibitory effect of porcine Gal(1-16) on pancreatic secretion in the rat.
Negative_regulation (effect) of Gal
19) Confidence 0.37 Published 2000 Journal Res Exp Med (Berl) Section Abstract Doc Link 10815756 Disease Relevance 0 Pain Relevance 0
In conclusion, the inhibitory effect of Gal(1-16) on exogenous and endogenous CCK-stimulated pancreatic secretion was found to be more potent in the presence of glucose both in anesthetized and in conscious rats.
Negative_regulation (effect) of Gal
20) Confidence 0.37 Published 2000 Journal Res Exp Med (Berl) Section Abstract Doc Link 10815756 Disease Relevance 0.06 Pain Relevance 0.03

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