INT50130

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 5.23
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3)
Anatomy Link Frequency
PGE2 3
PGE1 1
spinal cord 1
dorsal root ganglia 1
nociceptor 1
Ptger3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 2 99.80 Very High Very High Very High
allodynia 6 99.18 Very High Very High Very High
bradykinin 20 98.96 Very High Very High Very High
nociceptor 4 98.68 Very High Very High Very High
Spinal cord 2 98.60 Very High Very High Very High
agonist 126 98.52 Very High Very High Very High
Kinase C 3 98.36 Very High Very High Very High
Hyperalgesia 18 98.34 Very High Very High Very High
nMDA receptor 6 97.44 Very High Very High Very High
b2 receptor 4 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 99.18 Very High Very High Very High
Hyperalgesia 22 99.02 Very High Very High Very High
Asthma 1 98.00 Very High Very High Very High
Herpes Simplex Virus Infection 7 96.32 Very High Very High Very High
Pain 17 95.96 Very High Very High Very High
Ganglion Cysts 36 95.72 Very High Very High Very High
Herpes Simplex Virus 2 94.76 High High
Sensorineural Hearing Loss 20 93.64 High High
Post Operative Pain 7 92.00 High High
Pressure And Volume Under Development 11 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This segregation of EP receptor function within the airway suggests that PGE(2) analogs that selectively activate the EP2 receptor without activating the EP1/EP3 receptors might prove useful in the treatment of asthma.
Neg (without) Positive_regulation (activating) of EP3 associated with asthma
1) Confidence 0.67 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618422 Disease Relevance 0.10 Pain Relevance 0
In contrast, activation of EP3 inhibits adenylyl cyclase.
Positive_regulation (activation) of EP3
2) Confidence 0.64 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.06 Pain Relevance 0
Pre-activation of the H3 receptor slightly attenuates the EP3 receptor-mediated effect whereas pre-activation of the EP3 receptor more markedly attenuates the H3 receptor-mediated effect.
Positive_regulation (activation) of EP3
3) Confidence 0.56 Published 1997 Journal Neuroscience Section Abstract Doc Link 9178880 Disease Relevance 0 Pain Relevance 0.13
Intrathecal (i.t.) injection of prostaglandin E2 (PGE2) to conscious mice produced a hyperalgesic action over a wide range of dosages with two apparent peaks at 100 pg and 10 ng per mouse, which may be mediated through EP3 and EP2 subtypes of the PGE receptor.
Positive_regulation (mediated) of EP3 in PGE2 associated with hyperalgesia and intrathecal
4) Confidence 0.44 Published 1995 Journal Brain Res. Section Abstract Doc Link 7606458 Disease Relevance 0.47 Pain Relevance 0.71
These results first demonstrate that the NMDA receptor is involved in the PGE2-induced hyperalgesia and suggest that the hyperalgesic action by lower and higher doses of PGE2 may be mediated through EP3 and EP2 subtypes, respectively.
Positive_regulation (mediated) of EP3 in PGE2 associated with hyperalgesia and nmda receptor
5) Confidence 0.44 Published 1995 Journal Brain Res. Section Abstract Doc Link 7606458 Disease Relevance 0.79 Pain Relevance 1.19
These results suggest that gp120 induced allodynia by increasing [Ca2+]i, concomitant with activation of prostanoid EP3 and kappa-opioid receptors in the spinal cord.
Positive_regulation (activation) of prostanoid EP3 in spinal cord associated with allodynia, kappa opioid receptor and spinal cord
6) Confidence 0.43 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12814662 Disease Relevance 0.63 Pain Relevance 0.87
The results suggest the important roles of COX-2 induction and the PGE2-EP3 receptor system in the dorsal root ganglia in the development but not maintenance of acute herpetic pain.
Positive_regulation (induction) of EP3 in dorsal root ganglia associated with pain and herpes simplex virus infection
7) Confidence 0.38 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15925391 Disease Relevance 1.52 Pain Relevance 1.07
Conversely, activation of EP3 inhibits adenylate cyclase (Sugimoto et al. 1992).
Positive_regulation (activation) of EP3
8) Confidence 0.37 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.14 Pain Relevance 0.23
By contrast, the activation of EP3 decreases cAMP levels, which suggests that the selective activation of EP2 and/or EP4 might increase the clinical efficacy of PGE1 for the treatment of acute SNHL.
Positive_regulation (activation) of EP3 in PGE1 associated with sensorineural hearing loss
9) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.65 Pain Relevance 0.22
PGE2-stimulation of EP2 or EP3 induces an increase or a decrease in the level of cAMP, respectively, in the cytosol via adenyl cyclase (Jumblatt and Paterson, 1991; Sugimoto et al. 1992).
Positive_regulation (stimulation) of EP3
10) Confidence 0.25 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.38
EP2 and EP4 are coupled to G-protein stimulation and mediate increases in cAMP, while the activation of EP3 leads to a decrease of cAMP levels.
Positive_regulation (activation) of EP3
11) Confidence 0.20 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.38 Pain Relevance 0.23
These results demonstrate that the activation of EP3 restores the response to BK by attenuating the desensitization of BK B2 receptor activity via Gi protein.
Positive_regulation (activation) of EP3 associated with b2 receptor and bradykinin
12) Confidence 0.17 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17176262 Disease Relevance 0.07 Pain Relevance 0.76
Collectively, these findings indicate that edematogenic responses elicited by PGE2 are mediated by EP3 receptor activation, also involving the stimulation of PLC, PKC, and MAPKs pathways and the participation of TRPV1 and NK1 receptors.
Positive_regulation (activation) of EP3 receptor in PGE2 associated with kinase c
13) Confidence 0.14 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16644903 Disease Relevance 0.35 Pain Relevance 0.42
We previously demonstrated that the activation of prostaglandin E-prostanoid-3 (EP3) receptor sensitized the canine nociceptor response to bradykinin (BK).
Positive_regulation (activation) of EP3 in nociceptor associated with nociceptor and bradykinin
14) Confidence 0.10 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17176262 Disease Relevance 0.07 Pain Relevance 0.27

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