INT50135

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.70
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dcn) extracellular region (Dcn) proteinaceous extracellular matrix (Dcn)
Anatomy Link Frequency
inferior olive 1
mast cell 1
Dcn (Mus musculus)
Pain Link Frequency Relevance Heat
depression 56 99.72 Very High Very High Very High
dexamethasone 2 98.16 Very High Very High Very High
anesthesia 5 91.68 High High
aspirin 1 89.92 High High
cINOD 1 66.80 Quite High
Action potential 2 40.24 Quite Low
metalloproteinase 10 19.40 Low Low
backache 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 56 99.72 Very High Very High Very High
Intervertebral Disk Degeneration 44 98.94 Very High Very High Very High
Hemorrhage 1 82.96 Quite High
Syndrome 2 77.28 Quite High
INFLAMMATION 3 65.36 Quite High
Disease 4 14.96 Low Low
Low Back Pain 10 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Spinal Stenosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Less is known of how the small proteoglycan population changes with disc degeneration, although there is some evidence that the amount of decorin, and more particularly biglycan, is elevated in degenerate human discs as compared with normal ones [34].
Positive_regulation (elevated) of decorin associated with intervertebral disk degeneration
1) Confidence 0.45 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165040 Disease Relevance 0.17 Pain Relevance 0
PGS-2 induction following mast cell activation is blocked by dexamethasone.
Positive_regulation (induction) of PGS-2 in mast cell associated with dexamethasone
2) Confidence 0.27 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0.07 Pain Relevance 0.20
Increased marker density in this chromosomal region would be required before an epistatic analysis between this locus and the Dc locus could be conducted.
Positive_regulation (conducted) of Dc
3) Confidence 0.24 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0.16 Pain Relevance 0
Further studies, both in anaesthetized and awake behaving animals, are required for investigating the synchronization of Purkinje-cell pauses and the output of the DCN after LTD and how they contribute to cerebellar learning.


Positive_regulation (pauses) of DCN associated with depression
4) Confidence 0.15 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.30 Pain Relevance 0.24
This would be especially true if there is synchronization of SS pauses within cerebellar microzones (Andersson and Oscarsson, 1978; Sugihara et al., 1999): a small cluster of neurons in the inferior olive (IO) can generate nearly simultaneous CS throughout the extent of a single cerebellar microzone, and thus CS firing could lead to synchronous pause onset and offset in the cerebellar cortex microzone which in turn will either silence or activate a single DCN.
Positive_regulation (activate) of DCN in inferior olive
5) Confidence 0.03 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2671936 Disease Relevance 0 Pain Relevance 0

General Comments

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