INT50146

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 0.90
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dcn) extracellular region (Dcn) proteinaceous extracellular matrix (Dcn)
Anatomy Link Frequency
mast cell 3
B cells 1
neurons 1
Purkinje cells 1
forebrain 1
Dcn (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 39 99.04 Very High Very High Very High
Hippocampus 23 98.52 Very High Very High Very High
ketamine 9 96.24 Very High Very High Very High
anesthesia 8 95.16 Very High Very High Very High
dexamethasone 6 94.48 High High
cINOD 3 94.36 High High
aspirin 3 88.08 High High
Action potential 42 87.36 High High
Potency 11 65.28 Quite High
Thalamus 2 55.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.28 Very High Very High Very High
INFLAMMATION 5 94.16 High High
Death 3 86.16 High High
Ataxia 25 73.04 Quite High
Stress 3 69.40 Quite High
Depression 56 44.24 Quite Low
Hemorrhage 9 41.04 Quite Low
Syndrome 12 37.16 Quite Low
Schizophrenia 28 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, activation of MMC-34 or bone marrow-derived mast cells induces expression of the PG synthase 2 (PGS-2) gene.
Gene_expression (expression) of PGS-2 in mast cells
1) Confidence 0.51 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0.06 Pain Relevance 0.19
These data demonstrate that mast cell activation results 1) in the induction of PGS-2 gene expression, and 2) in both PGS-1-dependent PGD2 synthesis and PGD2 synthesis that is dependent on the activation-induced synthesis and activity of PGS-2.
Gene_expression (expression) of PGS-2 in mast cell
2) Confidence 0.51 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0.09 Pain Relevance 0.22
These data demonstrate that mast cell activation results 1) in the induction of PGS-2 gene expression, and 2) in both PGS-1-dependent PGD2 synthesis and PGD2 synthesis that is dependent on the activation-induced synthesis and activity of PGS-2.
Gene_expression (synthesis) of PGS-2 in mast cell
3) Confidence 0.38 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7608559 Disease Relevance 0.09 Pain Relevance 0.21
This was detected in the DCN, but not in material taken from the hippocampus or from a section through the forebrain.
Neg (not) Gene_expression (detected) of DCN in forebrain associated with hippocampus
4) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0.14 Pain Relevance 0.16
Electrophysiological recordings in DCN neurons of Lc/+ strongly support this hypothesis.
Gene_expression (neurons) of DCN in neurons
5) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0.09 Pain Relevance 0.04
DCN tissue was dissected from parasagittal cerebellar slices (400–500 ?
Gene_expression (tissue) of DCN
6) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0 Pain Relevance 0.14
For these discordant animals, the CHROMPIC analysis including the SILV c.64A>G mutation and the Dc locus (presumed genotypes based on phenotypes) did not suggest genotyping errors for the tested mutation, however, most of these animals appeared as double recombinants at the Dc locus.
Gene_expression (locus) of Dc
7) Confidence 0.33 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
Based on the lack of convincing recombinants between the SILV c.64A>G mutation and the Dc locus, this allelic variant of the SILV gene cannot be ruled out as the causal mutation of the Charolais dilution phenotype.
Gene_expression (locus) of Dc
8) Confidence 0.33 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
This analysis positioned the Dc locus in the same marker interval as SILV c.64A>G (recombination fraction, ?
Gene_expression (locus) of Dc
9) Confidence 0.33 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
However, the Dc locus was involved in unlikely double recombination events (resulting in ?
Gene_expression (locus) of Dc
10) Confidence 0.33 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
Using the five-category dataset (White, Grey, Light-Red, Dark-Red and Black), the observed proportions of individuals included in each of the classes were compared with those calculated under the hypothesis of fixation of alternative alleles in the founder lines (Charolais genotype: Dc/Dc; Holstein genotype: dc+/dc+) using ?
Gene_expression (/) of dc
11) Confidence 0.28 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
Using the five-category dataset (White, Grey, Light-Red, Dark-Red and Black), the observed proportions of individuals included in each of the classes were compared with those calculated under the hypothesis of fixation of alternative alleles in the founder lines (Charolais genotype: Dc/Dc; Holstein genotype: dc+/dc+) using ?
Gene_expression (/) of Dc
12) Confidence 0.28 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
Using the five-category dataset (White, Grey, Light-Red, Dark-Red and Black), the observed proportions of individuals included in each of the classes were compared with those calculated under the hypothesis of fixation of alternative alleles in the founder lines (Charolais genotype: Dc/Dc; Holstein genotype: dc+/dc+) using ?
Gene_expression (/) of Dc
13) Confidence 0.28 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
Charolais fixed for "A" and Dc, Holstein fixed for "G" and dc+).
Gene_expression (fixed) of Dc
14) Confidence 0.28 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
Using the five-category dataset (White, Grey, Light-Red, Dark-Red and Black), the observed proportions of individuals included in each of the classes were compared with those calculated under the hypothesis of fixation of alternative alleles in the founder lines (Charolais genotype: Dc/Dc; Holstein genotype: dc+/dc+) using ?
Gene_expression (/) of dc
15) Confidence 0.28 Published 2007 Journal BMC Genet Section Body Doc Link PMC1994163 Disease Relevance 0 Pain Relevance 0
Aizenman and Linden (1999) have suggested that DCN neurons could use the RD to distinguish between PF and CF input to their presynaptic Purkinje cells.
Gene_expression (neurons) of DCN in Purkinje cells
16) Confidence 0.20 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0 Pain Relevance 0.07
The SK channels responsible for these effects are most likely formed by SK1 and SK2 subunits, while no [32, 82] or only weak [36] SK3 expression was detected in the DCN.
Gene_expression (detected) of DCN
17) Confidence 0.12 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0.07
In transgenic mouse lines, SK3-1B was only detected in DCN neurons within the cerebellum and consequently suppressed all SK-mediated currents in these neurons.
Gene_expression (neurons) of DCN in cerebellum associated with targeted disruption
18) Confidence 0.12 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.26 Pain Relevance 0.04
+) and plasmacytoid DC (CD11c+, B220+), the latter subtype expressing the CD45 isoform (B220) that is normally expressed by B cells [36], [37], [38].
Gene_expression (expressing) of plasmacytoid DC in B cells
19) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0.03

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