INT5016

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 129
Total Number 132
Disease Relevance 36.74
Pain Relevance 59.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 8
brain 7
median eminence 7
nucleus 6
neurons 4
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 166 100.00 Very High Very High Very High
amygdala 65 100.00 Very High Very High Very High
Opioid 63 100.00 Very High Very High Very High
tetrodotoxin 10 100.00 Very High Very High Very High
Morphine 120 99.98 Very High Very High Very High
GABAergic 4 99.98 Very High Very High Very High
lidocaine 2 99.98 Very High Very High Very High
withdrawal 71 99.96 Very High Very High Very High
Fibrositis 227 99.84 Very High Very High Very High
carbamazepine 7 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 373 100.00 Very High Very High Very High
Hypoglycemia 7 99.98 Very High Very High Very High
Fibromyalgia 192 99.84 Very High Very High Very High
Eating Disorder 11 99.82 Very High Very High Very High
Sleep Disorders 48 99.80 Very High Very High Very High
Anovulation 18 99.80 Very High Very High Very High
Weight Loss 4 99.66 Very High Very High Very High
Infantile Spasms 190 99.64 Very High Very High Very High
Body Weight 5 99.56 Very High Very High Very High
Urological Neuroanatomy 18 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first phase (at 10-15 sec) consisted of an "urgent" mobilization of the " basal" reserves of hormonally active substances and was characterized by suppression of corticoliberin activity in the hypothalamus and extrahypothalamic brain structures in rats, with a parallel increase in the plasma concentration of adrenocorticotropic hormone, draining of corticosteroid reserves in the adrenals, and decreases in blood corticosterone levels on the background of increases in corticosterone levels in target organs.
Negative_regulation (suppression) of corticoliberin in hypothalamus associated with corticosteroid
1) Confidence 0.59 Published 2006 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 16645774 Disease Relevance 0.23 Pain Relevance 0.05
Although prednisolone resulted in a marked reduction of basal CRF mRNA, the stress-induced increment of CRF mRNA remained comparable with that found in untreated animals.
Negative_regulation (reduction) of CRF mRNA associated with stress
2) Confidence 0.59 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.33 Pain Relevance 0.11
Prenatal morphine reduced both CRF content in the newborn hypothalamus and CRF immunofluorescence in the median eminence without a significant effect on CRF mRNA expression in the PVN.
Negative_regulation (reduced) of CRF in PVN associated with morphine
3) Confidence 0.58 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.16 Pain Relevance 0.91
Levels of CRH and neurotensin mRNAs were decreased on the lesioned side in the CEA and oval nucleus of the BST (BSTov) relative to the intact side and to unoperated controls.
Negative_regulation (decreased) of CRH in oval nucleus associated with amygdala
4) Confidence 0.58 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.67
The present study was performed in order to determine (1) if the lesion resulted in a decrease in CRH mRNA, and/or if there was upregulation on the intact side, (2) if a similar imbalance in CRH mRNA was observed in other brain regions and (3) if levels of other neuropeptide mRNAs were affected by the lesion.
Negative_regulation (decrease) of CRH mRNA in brain associated with neuropeptide
5) Confidence 0.58 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.50
They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings.
Negative_regulation (decreases) of CSF CRH associated with depression
6) Confidence 0.58 Published 1993 Journal Am J Psychiatry Section Abstract Doc Link 8465888 Disease Relevance 0.17 Pain Relevance 0.35
The suppression of the CRH gene in late pregnancy and parturition may lead to the previously reported reduction in stress responses during lactation.
Negative_regulation (suppression) of CRH gene associated with stress
7) Confidence 0.58 Published 1994 Journal Gene Ther. Section Abstract Doc Link 8542431 Disease Relevance 0.17 Pain Relevance 0.16
Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus.
Negative_regulation (decreased) of corticotropin-releasing hormone in hypothalamus associated with locus ceruleus and fluoxetine
8) Confidence 0.58 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.08 Pain Relevance 0.41
Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus.
Negative_regulation (decreased) of CRH in hypothalamus associated with locus ceruleus and fluoxetine
9) Confidence 0.58 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.08 Pain Relevance 0.41
However, in contrast to saline-injected controls, this activation was not maintained because declines in CRH hnRNA and mRNA were seen as the stress continued.
Negative_regulation (declines) of CRH hnRNA associated with stress
10) Confidence 0.58 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929082 Disease Relevance 0.41 Pain Relevance 0.04
Laparotomy also caused a significant depletion of corticotropin-releasing hormone (CRH-41) in the median eminence (ME).
Negative_regulation (depletion) of CRH in median eminence
11) Confidence 0.56 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10810250 Disease Relevance 0.16 Pain Relevance 0.32
Laparotomy also caused a significant depletion of corticotropin-releasing hormone (CRH-41) in the median eminence (ME).
Negative_regulation (depletion) of corticotropin-releasing hormone in median eminence
12) Confidence 0.56 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10810250 Disease Relevance 0.16 Pain Relevance 0.32
Small decreases (10-13%) in hypothalamic CRH mRNA levels were found again to be induced by 3 days of repeated 'binge' cocaine.
Negative_regulation (decreases) of CRH mRNA associated with cocaine
13) Confidence 0.56 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.24 Pain Relevance 0.69
In contrast, after 3 days of 'binge' cocaine, there was a modest decrease (12%) in hypothalamic CRH mRNA levels, which after 14 days of 'binge' cocaine was greater (32%) and significantly lower than control values.
Negative_regulation (decrease) of CRH mRNA associated with cocaine
14) Confidence 0.56 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.14 Pain Relevance 0.40
This blunting of HPA axis activity in response to cocaine is associated with a cocaine-induced reduction of corticotropin-releasing hormone (CRH) mRNA level in the hypothalamus.
Negative_regulation (reduction) of CRH in hypothalamus associated with cocaine
15) Confidence 0.55 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576179 Disease Relevance 0 Pain Relevance 0.51
This blunting of HPA axis activity in response to cocaine is associated with a cocaine-induced reduction of corticotropin-releasing hormone (CRH) mRNA level in the hypothalamus.
Negative_regulation (reduction) of corticotropin-releasing hormone in hypothalamus associated with cocaine
16) Confidence 0.55 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576179 Disease Relevance 0 Pain Relevance 0.51
CRH mRNA was decreased after thyroidectomy, whereas the T4 restitution caused an upregulation.
Negative_regulation (decreased) of CRH mRNA
17) Confidence 0.54 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1283206 Disease Relevance 0.32 Pain Relevance 0.22
The present study investigates the possible role of endogenous opioid peptides in mediating the inhibitory effect of corticotropin-releasing factor (CRF) on circulating luteinizing hormone (LH).
Negative_regulation (effect) of CRF associated with endogenous opioid
18) Confidence 0.53 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893271 Disease Relevance 0 Pain Relevance 0.34
The present study investigates the possible role of endogenous opioid peptides in mediating the inhibitory effect of corticotropin-releasing factor (CRF) on circulating luteinizing hormone (LH).
Negative_regulation (effect) of corticotropin-releasing factor associated with endogenous opioid
19) Confidence 0.53 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893271 Disease Relevance 0 Pain Relevance 0.34
However, levels of mRNA encoding for CRH were decreased in the PVN during morphine dependence and withdrawal.
Negative_regulation (decreased) of CRH in PVN associated with addiction, withdrawal and morphine
20) Confidence 0.52 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12431775 Disease Relevance 0.27 Pain Relevance 1.39

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