INT5017

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 76
Total Number 78
Disease Relevance 17.00
Pain Relevance 57.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
neurons 9
spinal cord 7
spinal 4
dorsal horn 4
brain 3
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 596 100.00 Very High Very High Very High
qutenza 466 100.00 Very High Very High Very High
antagonist 179 100.00 Very High Very High Very High
Calcitonin gene-related peptide 178 100.00 Very High Very High Very High
Spinal cord 174 100.00 Very High Very High Very High
Dorsal horn 144 100.00 Very High Very High Very High
Pain 142 100.00 Very High Very High Very High
Neuropeptide 78 100.00 Very High Very High Very High
nociceptor 71 100.00 Very High Very High Very High
Dorsal horn neuron 35 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 1 99.84 Very High Very High Very High
Nociception 167 99.44 Very High Very High Very High
Stress 42 99.38 Very High Very High Very High
Pain 157 99.18 Very High Very High Very High
INFLAMMATION 237 99.16 Very High Very High Very High
Hypoxia 7 99.16 Very High Very High Very High
Headache 7 98.88 Very High Very High Very High
Cluster Headache 1 98.36 Very High Very High Very High
Diabetes Mellitus 65 97.50 Very High Very High Very High
Hyperalgesia 55 97.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of loss of lamina I NK-1R staining, lumbar intrathecal SSP-sap was seven times more potent than SP-sap and produced no loss of NK-1R expressing neurons in deeper laminae (III-VI or X).
Neg (no) Negative_regulation (loss) of NK-1R in neurons associated with intrathecal
1) Confidence 0.58 Published 2007 Journal Neuroscience Section Abstract Doc Link 17418497 Disease Relevance 0.23 Pain Relevance 0.54
Furthermore, the data suggest that a decrease in affinity of the neurokinin1 receptor may contribute, in part, to tachyphylaxis to substance P.
Negative_regulation (decrease) of neurokinin1 receptor associated with substance p
2) Confidence 0.58 Published 1995 Journal Neuroscience Section Abstract Doc Link 8848112 Disease Relevance 0 Pain Relevance 0.50
Thus the continuous infusion of SP stimulates plasma extravasation in the rat pancreas via activation of the NK1-R, and these effects are terminated by both desensitization of the NK1-R and the cell-surface protease NEP.
Negative_regulation (desensitization) of NK1-R in pancreas associated with substance p
3) Confidence 0.58 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11005759 Disease Relevance 0 Pain Relevance 0.38
However, spinal application of substance P (SP) in the antisense oligonucleotide-treated animals resulted in a profound and long-lasting reduction in the behavioural response to formalin injection, and a parallel reduction in the NK1 receptor immunoreactivity normally observed in spinal dorsal horn.
Negative_regulation (reduction) of NK1 receptor in dorsal horn associated with spinal dorsal horn and substance p
4) Confidence 0.58 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9453563 Disease Relevance 0.16 Pain Relevance 0.52
Tachykinin receptor inhibition and c-Fos expression in the rat brain following formalin-induced pain.
Negative_regulation (inhibition) of Tachykinin receptor in brain associated with pain and analgesic
5) Confidence 0.52 Published 2000 Journal Neuroscience Section Title Doc Link 10670449 Disease Relevance 0.29 Pain Relevance 0.79
On the basis of loss of lamina I NK-1R staining, lumbar intrathecal SSP-sap was seven times more potent than SP-sap and produced no loss of NK-1R expressing neurons in deeper laminae (III-VI or X).
Negative_regulation (loss) of lamina I NK-1R in neurons associated with intrathecal
6) Confidence 0.51 Published 2007 Journal Neuroscience Section Abstract Doc Link 17418497 Disease Relevance 0.24 Pain Relevance 0.57
In situ hybridization assay results demonstrated that either pain or stress (acute or chronic treatments) reduced the levels of both NK-1 receptor and BDNF mRNAs in the cornu ammonis 1-3 sublayers of the hippocampus, suggesting a possible role of these neuromediators in processing of pain in higher brain centers.
Negative_regulation (reduced) of NK-1 receptor in brain associated with stress, pain and hippocampus
7) Confidence 0.47 Published 2006 Journal J Pain Section Abstract Doc Link 16885011 Disease Relevance 1.78 Pain Relevance 1.17
Considering that capsaicin did not affect the normal control baselines of these parameters except for a decrease in NK-1R mRNA, we conclude that the degree of SSCS-induced inflammatory response was exacerbated because of the depletion of stored SP and/or inactivation of capsaicin-sensitive C-fiber nerves.
Neg (except) Negative_regulation (decrease) of NK-1R mRNA in nerves associated with c fibre, inflammatory response, qutenza and substance p
8) Confidence 0.46 Published 2004 Journal Toxicology Section Abstract Doc Link 15297018 Disease Relevance 0.39 Pain Relevance 1.15
NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation.
Negative_regulation (desensitization) of NK-1 receptor in plasma associated with qutenza
9) Confidence 0.43 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11005759 Disease Relevance 0 Pain Relevance 0.48
Hypoxic response in newborn rat is attenuated by neurokinin-1 receptor blockade.
Negative_regulation (blockade) of neurokinin-1 receptor associated with analgesic
10) Confidence 0.42 Published 2004 Journal Respir Physiol Neurobiol Section Title Doc Link 15109925 Disease Relevance 0.66 Pain Relevance 0.48
Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor receive monosynaptic input from myelinated primary afferents.
Negative_regulation (possess) of neurokinin-1 in spinal cord associated with spinal cord
11) Confidence 0.42 Published 1998 Journal Eur. J. Neurosci. Section Title Doc Link 9758171 Disease Relevance 0.08 Pain Relevance 0.21
After intrathecal substance P-saporin (sP-SAP), NK1-r(+) cell bodies and dendrites in the superficial dorsal horn were largely abolished.
Negative_regulation (abolished) of NK1-r in dorsal horn associated with dorsal horn, substance p and intrathecal
12) Confidence 0.41 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037142 Disease Relevance 0.07 Pain Relevance 0.78
Under inflammatory conditions, all noxious stimulus-induced NK-1 receptor internalization in deep dorsal horn neurons was blocked by GR 205171, suggesting that it is entirely NKA-mediated.
Negative_regulation (blocked) of NK-1 receptor in neurons associated with inflammation and dorsal horn neuron
13) Confidence 0.40 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331395 Disease Relevance 0.17 Pain Relevance 0.79
We found, however, that the selective NK-1 receptor antagonist GR 205171 blocked NKA but not SP-induced NK-1 receptor internalization in the rat spinal cord in vivo and in embryonic day 19 rat spinal neurons in vitro.
Negative_regulation (blocked) of NK-1 receptor in neurons associated with antagonist, spinal cord and substance p
14) Confidence 0.40 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331395 Disease Relevance 0.15 Pain Relevance 0.72
After 5 days of morphine infusion, thermal escape latencies were the same as in preinfusion animals or saline-infused controls, and compression-evoked NK1r internalization was no longer suppressed.
Negative_regulation (suppressed) of NK1r associated with morphine
15) Confidence 0.38 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15908510 Disease Relevance 0 Pain Relevance 1.88
Our results demonstrate that blockade of brain tachykinin receptors, especially of the neurokinin-1 receptor, reduces the behavioural response to pain and the pain-induced c-Fos activation in distinct brain areas which are intimately linked with nociceptive neurotransmission and the initiation and integration of central stress responses.
Negative_regulation (blockade) of neurokinin-1 receptor in brain associated with stress, nociception and pain
16) Confidence 0.38 Published 2000 Journal Neuroscience Section Abstract Doc Link 10670449 Disease Relevance 0.78 Pain Relevance 0.90
NK-1R pre-mRNA species were enriched in the nuclear fractions of spinal cord samples, and in the steady state, total molar amounts of NK-1R pre-mRNAs were 2-fold greater than those of mature NK-1R mRNA.
Negative_regulation (amounts) of NK-1R in molar associated with spinal cord
17) Confidence 0.38 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.23 Pain Relevance 0.20
SPR blockade may prove to be a novel therapy used to prevent intestinal inflammation.


Negative_regulation (blockade) of SPR
18) Confidence 0.38 Published 1996 Journal Gastroenterology Section Body Doc Link 8898641 Disease Relevance 0.06 Pain Relevance 0
Reduced substance P in hereditary sensory neuropathy in the mf rat.
Negative_regulation (Reduced) of substance P associated with nociceptor, hsan and substance p
19) Confidence 0.38 Published 1983 Journal Brain Res. Section Title Doc Link 6188515 Disease Relevance 0.50 Pain Relevance 0.81
Rats were injected with capsaicin at 1-2 days of age to abolish the content of substance P (SP) in nerve terminals.
Negative_regulation (abolish) of substance P in nerve associated with qutenza and substance p
20) Confidence 0.38 Published 1986 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 3721596 Disease Relevance 0 Pain Relevance 0.48

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