INT50174

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.32
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
sciatic nerve 2
striatum 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 108 99.68 Very High Very High Very High
anesthesia 2 99.16 Very High Very High Very High
Sciatic nerve 1 98.44 Very High Very High Very High
Somatostatin 1 96.68 Very High Very High Very High
Calcitonin gene-related peptide 1 94.28 High High
Neuropeptide 10 90.08 High High
Inflammation 4 86.08 High High
Arthritis 1 82.32 Quite High
Substantia nigra 3 79.40 Quite High
cerebral cortex 2 78.04 Quite High
Disease Link Frequency Relevance Heat
Arthritis 1 82.32 Quite High
Nociception 2 81.80 Quite High
Neurogenic Inflammation 1 81.16 Quite High
INFLAMMATION 2 75.00 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found significant increases in the expression of Nts, Nmu, and Tac2 and decreases in Tac1 expression in the DA-depleted striata of rats treated with saline.
Negative_regulation (decreases) of Gene_expression (expression) of Tac1 associated with dopamine
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.34
The changes in PPT mRNA expression were prevented by concurrent local anesthesia of the sciatic nerve.
Negative_regulation (prevented) of Gene_expression (expression) of PPT mRNA in sciatic nerve associated with anesthesia and sciatic nerve
2) Confidence 0.35 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970189 Disease Relevance 0.32 Pain Relevance 0.57
Dopamine-depleting 6-OHDA lesions resulted in a marked increase in PPE mRNA levels and a concomitant decrease in PPT mRNA expression both in the remaining host striatum and in the P-regions of the graft.
Negative_regulation (decrease) of Gene_expression (expression) of PPT in striatum associated with dopamine
3) Confidence 0.02 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609615 Disease Relevance 0 Pain Relevance 0.21

General Comments

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