INT50176

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Context Info
Confidence 0.22
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
striatum 4
spinal cord 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 4 98.14 Very High Very High Very High
Neuropeptide 4 83.88 Quite High
Substantia nigra 2 79.40 Quite High
cerebral cortex 2 78.04 Quite High
Neurotransmitter 2 75.00 Quite High
Enkephalin 6 57.76 Quite High
Pain 5 50.00 Quite Low
Acupuncture 3 50.00 Quite Low
Antinociceptive 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 71.40 Quite High
Nociception 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Needle manipulation was also effective in suppressing the mRNA expression of pain-related genes such as Fos, opioid receptor-like 1, tachykinin 1, tachykinin receptor 1, mu-opioid receptor and 5-hydroxytryptamine receptor 2A in the spinal cord.
Negative_regulation (suppressing) of Transcription (expression) of tachykinin 1 in spinal cord
1) Confidence 0.22 Published 2010 Journal Neurol. Res. Section Body Doc Link 20034454 Disease Relevance 0.07 Pain Relevance 0
Dopamine-depleting 6-OHDA lesions resulted in a marked increase in PPE mRNA levels and a concomitant decrease in PPT mRNA expression both in the remaining host striatum and in the P-regions of the graft.
Negative_regulation (decrease) of Transcription (expression) of PPT in striatum associated with dopamine
2) Confidence 0.02 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609615 Disease Relevance 0 Pain Relevance 0.21
The cortical lesions had no significant effect on the 6-OHDA-induced reduction of PPT mRNA levels neither in the remaining lost striatum nor in the striatal graft.
Negative_regulation (reduction) of Transcription (levels) of PPT in striatum
3) Confidence 0.02 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609615 Disease Relevance 0 Pain Relevance 0.21

General Comments

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