INT50191

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 3.44
Pain Relevance 7.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
MDM 4
lymphocytes 4
fibroblasts 3
Caco-2 2
skin 2
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 55 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
agonist 6 99.58 Very High Very High Very High
cocaine 2 99.40 Very High Very High Very High
rheumatoid arthritis 13 99.24 Very High Very High Very High
Endogenous opioid 6 99.00 Very High Very High Very High
Morphine 17 98.84 Very High Very High Very High
alcohol 4 97.28 Very High Very High Very High
chemokine 2 95.76 Very High Very High Very High
mu opioid receptor 6 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 13 99.24 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 96.56 Very High Very High Very High
INFLAMMATION 6 94.92 High High
Infection 4 94.12 High High
Pain 3 93.92 High High
Drug Dependence 1 75.00 Quite High
Keloid Scars 12 70.72 Quite High
Targeted Disruption 2 44.16 Quite Low
Nociception 5 5.00 Very Low Very Low Very Low
Pruritus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the results from skin biopsy, we observed enhanced expression of MOR, DOR and KOR in the cultured keratinocytes and fibroblasts derived from hypertrophic scars in comparison with those derived from normal skin.
Positive_regulation (enhanced) of Gene_expression (expression) of KOR in fibroblasts
1) Confidence 0.67 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0
The present study further demonstrates that the KOR of lymphocytes are activated in the presence of extracellular morphine or U50,488H, a KOR selective agonist, and the activation causes an increase in the expression of KOR mRNA, as determined by a quantitative competitive Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) procedure.
Positive_regulation (causes) of Gene_expression (expression) of KOR mRNA in lymphocytes associated with agonist, kappa opioid receptor and morphine
2) Confidence 0.65 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11562065 Disease Relevance 0 Pain Relevance 1.06
Our findings suggest that the levels of expression of kappa-opioid receptor mRNA were decreased in RA patients in comparison with those in healthy volunteers; and that they were significantly related to the inflammatory activity or chronic pain in the RA patients.
Positive_regulation (levels) of Gene_expression (expression) of kappa-opioid receptor mRNA associated with inflammation, lasting pain, rheumatoid arthritis and kappa opioid receptor
3) Confidence 0.50 Published 2000 Journal Rheumatol. Int. Section Abstract Doc Link 10776687 Disease Relevance 1.38 Pain Relevance 1.20
Also, expression of KOR mRNA and binding activity with a fluorescence-labeled KOR ligand supported the existence of KOR on MDM.
Positive_regulation (supported) of Gene_expression (expression) of KOR mRNA in MDM associated with kappa opioid receptor
4) Confidence 0.50 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245971 Disease Relevance 0.87 Pain Relevance 0.60
Real-time PCR indicated that the expression of MOR, DOR and KOR in hypertrophic scars was enhanced in comparison with normal skin.
Positive_regulation (enhanced) of Gene_expression (expression) of KOR in skin
5) Confidence 0.49 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Our results demonstrate that expression of three types of ORs, MOR, DOR and KOR, was markedly upregulated in human hypertrophic scars, suggesting a possible link between upregulated ORs and local cacaesthesia in hypertrophic scars.


Positive_regulation (upregulated) of Gene_expression (expression) of KOR
6) Confidence 0.49 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0
A modulatory role of endogenous opioids is also suggested from biochemical data, showing increased dynorphin and kappa receptor expression after chronic cocaine treatment.
Positive_regulation (increased) of Gene_expression (expression) of kappa receptor associated with dynorphin, endogenous opioid and cocaine
7) Confidence 0.47 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9673788 Disease Relevance 0.07 Pain Relevance 1.83
The present study further demonstrates that the KOR of lymphocytes are activated in the presence of extracellular morphine or U50,488H, a KOR selective agonist, and the activation causes an increase in the expression of KOR mRNA, as determined by a quantitative competitive Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) procedure.
Positive_regulation (increase) of Gene_expression (expression) of KOR mRNA in lymphocytes associated with agonist, kappa opioid receptor and morphine
8) Confidence 0.44 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11562065 Disease Relevance 0 Pain Relevance 1.06
Also, expression of KOR mRNA and binding activity with a fluorescence-labeled KOR ligand supported the existence of KOR on MDM.
Positive_regulation (supported) of Gene_expression (expression) of KOR in MDM associated with kappa opioid receptor
9) Confidence 0.43 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245971 Disease Relevance 0.87 Pain Relevance 0.60
Consistent with the results from skin biopsy, we observed enhanced expression of MOR, DOR and KOR in the cultured keratinocytes and fibroblasts derived from hypertrophic scars in comparison with those derived from normal skin.
Positive_regulation (enhanced) of in keratinocytes Gene_expression (expression) of KOR in fibroblasts
10) Confidence 0.23 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0
In the present study, we determined that Caco-2 cells express the kappa-opioid receptor and its activation by trans-(+/-)-3,4-dichloro-N-methyl-N[2-(1-pyrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate (U-50488) leads to decreased interleukin-8 secretion in the presence of interleukin-1beta.
Positive_regulation (activation) of Gene_expression (express) of kappa-opioid receptor in Caco-2 associated with kappa opioid receptor
11) Confidence 0.21 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706459 Disease Relevance 0 Pain Relevance 0.29
The purpose of the present study was to examine the coupling pattern of a recently cloned kappa-opioid receptor stably transfected in CHO cells to individual G alpha subunits with subsequent comparison to that observed previously for delta- and mu-opioid receptors.
Spec (examine) Positive_regulation (transfected) of Gene_expression (transfected) of kappa-opioid receptor associated with mu opioid receptor and kappa opioid receptor
12) Confidence 0.05 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609621 Disease Relevance 0 Pain Relevance 0.31
Interestingly, YFa treatment caused a decrease on day 4, followed by an increase in the expression of KOR1 from day 5 onward.
Positive_regulation (increase) of Gene_expression (expression) of KOR1
13) Confidence 0.01 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18183621 Disease Relevance 0 Pain Relevance 0.97

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