INT50195

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 7.41
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
spinal cord 6
TRG 4
macrophage 2
brain 2
body 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 18 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
glial activation 2 100.00 Very High Very High Very High
Thermal hyperalgesia 9 99.84 Very High Very High Very High
intrathecal 6 99.84 Very High Very High Very High
Morphine 12 99.68 Very High Very High Very High
tolerance 4 99.32 Very High Very High Very High
antagonist 8 98.54 Very High Very High Very High
IPN 1 97.48 Very High Very High Very High
depression 2 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Peptic Ulcer 6 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Hyperalgesia 13 99.84 Very High Very High Very High
Injury 5 98.36 Very High Very High Very High
Inflammatory Pain 1 97.48 Very High Very High Very High
Depression 2 97.20 Very High Very High Very High
INFLAMMATION 18 96.40 Very High Very High Very High
Pain 4 96.16 Very High Very High Very High
Ganglion Cysts 18 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study indicated that surgical incision could induce glial activation and segmental upregulation of IL-1beta in the spinal cord.
Positive_regulation (induce) of Positive_regulation (upregulation) of IL-1beta in spinal cord associated with spinal cord and glial activation
1) Confidence 0.67 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733810 Disease Relevance 0.07 Pain Relevance 0.50
Total RNA was isolated and Northern blot hybridization was performed and the quantity of brain tissue IL-1 beta mRNA is presented as percent relative radioactivity of IL-1 beta positive macrophage RNA which was loaded on same gel.
Positive_regulation (presented) of Positive_regulation (radioactivity) of IL-1 beta in macrophage
2) Confidence 0.50 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609633 Disease Relevance 0.54 Pain Relevance 0.29
This upregulation of binding sites for the opioid-releasing agents corticotropin-releasing hormone and interleukin-1 beta likely represents part of the body's local response to combat inflammatory pain.
Positive_regulation (upregulation) of Positive_regulation (opioid-releasing) of interleukin-1 beta in body associated with ipn and opioid
3) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8891603 Disease Relevance 0.24 Pain Relevance 0.93
However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization.
Positive_regulation (potentiated) of Positive_regulation (induced) of interleukin-1beta associated with necrosis, cancer, tolerance and morphine
4) Confidence 0.49 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18584332 Disease Relevance 0.37 Pain Relevance 0.71
We have reported recently that intrathecal (i.t.) injection of interleukin-1beta (IL-1beta), at a dose of 100 ng, induces inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in the spinal cord and results in thermal hyperalgesia in rats.
Positive_regulation (results) of Positive_regulation (injection) of interleukin-1beta in spinal cord associated with thermal hyperalgesia, spinal cord and intrathecal
5) Confidence 0.49 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.33 Pain Relevance 0.52
We have reported recently that intrathecal (i.t.) injection of interleukin-1beta (IL-1beta), at a dose of 100 ng, induces inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in the spinal cord and results in thermal hyperalgesia in rats.
Positive_regulation (induces) of Positive_regulation (injection) of interleukin-1beta in spinal cord associated with thermal hyperalgesia, spinal cord and intrathecal
6) Confidence 0.49 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.31 Pain Relevance 0.46
However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization.
Positive_regulation (potentiated) of Positive_regulation (induced) of IL-1beta associated with necrosis, cancer, tolerance and morphine
7) Confidence 0.49 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18584332 Disease Relevance 0.37 Pain Relevance 0.71
Treatment with combination of pyrilamine plus histamine caused an increase in gastric ulcer area and serum interleukin-1beta above the value observed in animals treated with saline, and this effect was accompanied by a decrease in gastric mucosal DNA synthesis.
Positive_regulation (caused) of Positive_regulation (increase) of interleukin-1beta associated with peptic ulcer
8) Confidence 0.45 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680274 Disease Relevance 1.19 Pain Relevance 0.42
In addition, betamethasone reduced the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induced the expression of IL-10 in the brain, all of which correlated with the changes of pain thresholds in rats.
Positive_regulation (activation) of Positive_regulation (elevation) of IL-1beta in brain associated with pain
9) Confidence 0.45 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.92 Pain Relevance 0.88
Prostaglandins consistently mediate a stimulatory action of interleukin-1 beta on vasopressin release whereas alpha-adrenergic mechanisms mediate a depression of interleukin-1 beta-induced vasopressin release during the early to middle stages of lactation.
Positive_regulation (mediate) of Positive_regulation (action) of interleukin-1 beta associated with depression
10) Confidence 0.39 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8953469 Disease Relevance 0.18 Pain Relevance 0.13
The firing rates of the Adelta-TRG neuronal spontaneous activity were current-dependently decreased by local iontophoretic application of an interleukin I receptor type I antagonist (IL-1ra) in inflamed rats, but not in controls, and current-dependently increased by iontophoretic application of interleukin 1beta (IL-1beta) in both control and inflamed rats.
Neg (not) Positive_regulation (increased) of Positive_regulation (application) of IL-1beta in TRG associated with antagonist, trigeminal ganglion and adelta
11) Confidence 0.24 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18440198 Disease Relevance 1.35 Pain Relevance 0.83
The firing rates of the Adelta-TRG neuronal spontaneous activity were current-dependently decreased by local iontophoretic application of an interleukin I receptor type I antagonist (IL-1ra) in inflamed rats, but not in controls, and current-dependently increased by iontophoretic application of interleukin 1beta (IL-1beta) in both control and inflamed rats.
Neg (not) Positive_regulation (increased) of Positive_regulation (application) of interleukin 1beta in TRG associated with antagonist, trigeminal ganglion and adelta
12) Confidence 0.24 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18440198 Disease Relevance 1.34 Pain Relevance 0.81
The addition of PGE2 to cells augmented the ability of IL-1beta to upregulate PGS-2 transcripts.
Positive_regulation (augmented) of Positive_regulation (ability) of IL-1beta
13) Confidence 0.05 Published 1999 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 10619394 Disease Relevance 0.20 Pain Relevance 0.48

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