INT50196

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 19.08
Pain Relevance 10.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
brain 3
macrophage 2
spinal cord 2
blood 2
sciatic nerves 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 66 100.00 Very High Very High Very High
cytokine 45 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Hippocampus 34 99.92 Very High Very High Very High
Thalamus 3 99.12 Very High Very High Very High
Spinal cord 37 99.02 Very High Very High Very High
Arthritis 6 98.84 Very High Very High Very High
Central nervous system 26 97.56 Very High Very High Very High
anesthesia 9 94.80 High High
c fibre 2 94.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 80 100.00 Very High Very High Very High
Cancer 14 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Injury 75 99.96 Very High Very High Very High
Brain Injury 19 99.82 Very High Very High Very High
Sepsis 30 99.72 Very High Very High Very High
Convulsion 21 99.66 Very High Very High Very High
Spinal Cord Injury 63 99.02 Very High Very High Very High
Arthritis 12 98.84 Very High Very High Very High
Pancreatitis 11 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis.
Transcription (expression) of IL-1beta associated with arthritis
1) Confidence 0.69 Published 2008 Journal J. Microbiol. Biotechnol. Section Title Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.49
This study examined the time course of mRNA levels of the proinflammatory cytokines interferon-gamma (IFNgamma), interleukin-1beta (IL1beta), interleukin-12 (IL12; p40 subunit), and the immunosuppressant interleukin-10 (IL10) by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in rats with actively induced experimental autoimmune neuritis (EAN) and in distal stumps of crushed sciatic nerves undergoing Wallerian degeneration.
Transcription (levels) of IL1beta in sciatic nerves associated with experimental autoimmune neuritis, wallerian degeneration, sciatic nerve, neuritis and cytokine
2) Confidence 0.69 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.56 Pain Relevance 0.49
This study examined the time course of mRNA levels of the proinflammatory cytokines interferon-gamma (IFNgamma), interleukin-1beta (IL1beta), interleukin-12 (IL12; p40 subunit), and the immunosuppressant interleukin-10 (IL10) by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in rats with actively induced experimental autoimmune neuritis (EAN) and in distal stumps of crushed sciatic nerves undergoing Wallerian degeneration.
Transcription (levels) of interleukin-1beta in sciatic nerves associated with experimental autoimmune neuritis, wallerian degeneration, sciatic nerve, neuritis and cytokine
3) Confidence 0.69 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.56 Pain Relevance 0.49
The levels of the tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) mRNA in the tissue were estimated by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (levels) of interleukin 1beta associated with necrosis and cancer
4) Confidence 0.69 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 1.08 Pain Relevance 0.62
Total RNA was isolated and Northern blot hybridization was performed and the quantity of brain tissue IL-1 beta mRNA is presented as percent relative radioactivity of IL-1 beta positive macrophage RNA which was loaded on same gel.
Transcription (loaded) of IL-1 beta in macrophage
5) Confidence 0.69 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609633 Disease Relevance 0.52 Pain Relevance 0.28
Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions.
Transcription (expressions) of IL-1beta associated with convulsion
6) Confidence 0.67 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.43 Pain Relevance 0.27
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Transcription (levels) of IL-1beta associated with inflammation and cytokine
7) Confidence 0.67 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.85 Pain Relevance 0.47
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Transcription (levels) of IL-1beta associated with inflammation and cytokine
8) Confidence 0.67 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.85 Pain Relevance 0.47
The levels of the tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) mRNA in the tissue were estimated by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (levels) of IL-1beta associated with necrosis and cancer
9) Confidence 0.67 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 1.08 Pain Relevance 0.62
Two weeks after the last induction of AP morphological signs of pancreatic damage, pancreatic blood flow (PBF), serum and pancreatic amylase activity, fecal chymotrypsin activity, pancreatic weight, pancreatic RNA and DNA content, as well as, serum interleukin-1beta (Il-1beta ) were assessed.
Transcription (activity) of Il-1beta in blood associated with pancreatitis
10) Confidence 0.67 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11016864 Disease Relevance 0.65 Pain Relevance 0.53
Moreover, a significant increase in the expression of mRNA for IL-1beta, GDNF and iNOS were observed 6h following the HFS conditioning (p<0.05, HFS vs. control).
Transcription (expression) of IL-1beta
11) Confidence 0.67 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19596210 Disease Relevance 0.25 Pain Relevance 0.82
Total RNA was isolated and Northern blot hybridization was performed and the quantity of brain tissue IL-1 beta mRNA is presented as percent relative radioactivity of IL-1 beta positive macrophage RNA which was loaded on same gel.
Transcription (presented) of IL-1 beta in macrophage
12) Confidence 0.62 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609633 Disease Relevance 0.54 Pain Relevance 0.29
In the present study, we characterized the regional expression of interleukin-1 beta (IL-1 beta) mRNA in specific brain regions following experimental lateral fluid-percussion traumatic brain injury (TBI) in rats.
Transcription (expression) of interleukin-1 beta in brain associated with brain injury
13) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609633 Disease Relevance 0.48 Pain Relevance 0.26
Experimental brain injury induces expression of interleukin-1 beta mRNA in the rat brain.
Transcription (expression) of interleukin-1 beta in brain associated with brain injury
14) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7609633 Disease Relevance 0.56 Pain Relevance 0.33
One mM amygdalin significantly inhibited the expression of TNF-alpha and IL-1beta mRNAs in LPS-treated RAW 264.7 cells.
Transcription (expression) of IL-1beta in RAW 264
15) Confidence 0.52 Published 2008 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.46
IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h.
Transcription (expression) of IL-1beta in cortex associated with hippocampus
16) Confidence 0.52 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.48 Pain Relevance 0.28
Liver IL-1beta mRNA and protein levels were significantly inhibited at 2, 4, and 8 hours in the laparotomy and laparoscopic groups.
Transcription (levels) of IL-1beta in Liver
17) Confidence 0.52 Published 2005 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 15956894 Disease Relevance 0.44 Pain Relevance 0.23
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Transcription (levels) of IL-1 beta associated with necrosis, cancer and apoptosis
18) Confidence 0.47 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.74 Pain Relevance 0.72
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Transcription (levels) of interleukin-1 beta associated with necrosis, cancer and apoptosis
19) Confidence 0.47 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.73 Pain Relevance 0.72
In the present study, we characterized the regional expression of interleukin-1 beta (IL-1 beta) mRNA in specific brain regions following experimental lateral fluid-percussion traumatic brain injury (TBI) in rats.
Transcription (expression) of IL-1 beta in brain associated with brain injury
20) Confidence 0.46 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609633 Disease Relevance 0.48 Pain Relevance 0.26

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