INT50197

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 8.95
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
macrophage 4
blood 2
brain 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 27 100.00 Very High Very High Very High
cytokine 11 100.00 Very High Very High Very High
Arthritis 3 98.84 Very High Very High Very High
Calcitonin gene-related peptide 7 97.72 Very High Very High Very High
Spinal cord 13 96.88 Very High Very High Very High
Central nervous system 9 96.52 Very High Very High Very High
Hippocampus 13 95.44 Very High Very High Very High
c fibre 1 95.32 Very High Very High Very High
Dorsal horn 4 95.00 High High
qutenza 6 94.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 100.00 Very High Very High Very High
Pancreatitis 10 100.00 Very High Very High Very High
Brain Injury 9 99.98 Very High Very High Very High
Convulsion 7 99.90 Very High Very High Very High
Arthritis 6 98.84 Very High Very High Very High
Cancer 3 95.16 Very High Very High Very High
Necrosis 3 94.92 High High
Apoptosis 2 93.96 High High
Rheumatoid Arthritis 3 93.24 High High
Injury 19 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total RNA was isolated and Northern blot hybridization was performed and the quantity of brain tissue IL-1 beta mRNA is presented as percent relative radioactivity of IL-1 beta positive macrophage RNA which was loaded on same gel.
Positive_regulation (radioactivity) of Transcription (loaded) of IL-1 beta in macrophage
1) Confidence 0.50 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609633 Disease Relevance 0.53 Pain Relevance 0.28
Moreover, a significant increase in the expression of mRNA for IL-1beta, GDNF and iNOS were observed 6h following the HFS conditioning (p<0.05, HFS vs. control).
Positive_regulation (increase) of Transcription (expression) of IL-1beta
2) Confidence 0.49 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19596210 Disease Relevance 0.25 Pain Relevance 0.82
Two weeks after the last induction of AP morphological signs of pancreatic damage, pancreatic blood flow (PBF), serum and pancreatic amylase activity, fecal chymotrypsin activity, pancreatic weight, pancreatic RNA and DNA content, as well as, serum interleukin-1beta (Il-1beta ) were assessed.
Positive_regulation (induction) of Transcription (activity) of Il-1beta in blood associated with pancreatitis
3) Confidence 0.49 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11016864 Disease Relevance 0.68 Pain Relevance 0.55
Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis.
Positive_regulation (inducible) of Transcription (expression) of IL-1beta associated with arthritis
4) Confidence 0.49 Published 2008 Journal J. Microbiol. Biotechnol. Section Title Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.49
Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions.
Neg (not) Positive_regulation (increase) of Transcription (expressions) of IL-1beta associated with convulsion
5) Confidence 0.49 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.43 Pain Relevance 0.27
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Positive_regulation (elevated) of Transcription (levels) of IL-1beta associated with inflammation and cytokine
6) Confidence 0.49 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.86 Pain Relevance 0.47
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Positive_regulation (elevated) of Transcription (levels) of IL-1beta associated with inflammation and cytokine
7) Confidence 0.49 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.85 Pain Relevance 0.47
Experimental brain injury induces expression of interleukin-1 beta mRNA in the rat brain.
Positive_regulation (induces) of Transcription (expression) of interleukin-1 beta in brain associated with brain injury
8) Confidence 0.46 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7609633 Disease Relevance 0.56 Pain Relevance 0.33
Total RNA was isolated and Northern blot hybridization was performed and the quantity of brain tissue IL-1 beta mRNA is presented as percent relative radioactivity of IL-1 beta positive macrophage RNA which was loaded on same gel.
Positive_regulation (presented) of Transcription (presented) of IL-1 beta in macrophage
9) Confidence 0.44 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609633 Disease Relevance 0.54 Pain Relevance 0.29
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increase) of Transcription (levels) of interleukin-1 beta associated with necrosis, cancer and apoptosis
10) Confidence 0.34 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.74 Pain Relevance 0.72
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increase) of Transcription (levels) of IL-1 beta associated with necrosis, cancer and apoptosis
11) Confidence 0.34 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.75 Pain Relevance 0.72

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