INT50209

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Context Info
Confidence 0.46
First Reported 1995
Last Reported 1996
Negated 4
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.97
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfc) extracellular space (Vegfc) extracellular region (Vegfc)
Vegfc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 8 99.84 Very High Very High Very High
antagonist 5 99.54 Very High Very High Very High
narcan 19 99.48 Very High Very High Very High
withdrawal 2 98.00 Very High Very High Very High
depression 4 97.76 Very High Very High Very High
rapifen 14 97.24 Very High Very High Very High
opiate 2 96.90 Very High Very High Very High
Hyperalgesia 2 96.48 Very High Very High Very High
tolerance 2 95.68 Very High Very High Very High
Spinal cord 12 92.48 High High
Disease Link Frequency Relevance Heat
Depression 4 97.76 Very High Very High Very High
Hyperalgesia 2 96.48 Very High Very High Very High
Nociception 6 95.04 Very High Very High Very High
Pain 1 53.96 Quite High
Shock 1 35.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application of the opiate, glycine, GABAA and GABAB receptor antagonists, naloxone (1 microM), strychnine (100 microM), bicuculline (100 microM) and phaclofen (100 microM) did not alter the depressant effects of lignocaine on the VRP.
Neg (not) Regulation (alter) of VRP associated with antagonist, narcan and opiate
1) Confidence 0.46 Published 1996 Journal Pain Section Abstract Doc Link 8867247 Disease Relevance 0.10 Pain Relevance 1.05
The monosynaptic component of the VRP was unaffected by lidocaine at any concentration, suggesting that the depression of the slow-VRP cannot be attributed to simple conduction block.
Neg (unaffected) Regulation (unaffected) of VRP associated with depression and lidocaine
2) Confidence 0.27 Published 1995 Journal Pain Section Abstract Doc Link 7784102 Disease Relevance 0.37 Pain Relevance 1.20
Naloxone (200 nM) alone produced no significant effect on sVRP area, while naloxone (560 nM) increased area to 121 +/- 17.7% of control (mean +/- SD).
Neg (no) Regulation (effect) of sVRP associated with narcan
3) Confidence 0.27 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7609918 Disease Relevance 0.25 Pain Relevance 0.95
The non-competitive NMDA antagonist MK-801 (20 nM) had no effect on sVRP area when applied alone; higher concentrations produced irreversible depression.
Neg (no) Regulation (effect) of sVRP associated with depression and antagonist
4) Confidence 0.23 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7609918 Disease Relevance 0.25 Pain Relevance 1.10

General Comments

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