INT50212

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 33
Total Number 36
Disease Relevance 32.17
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Scarpa's ganglion 2
tails 1
colon 1
spinal cord 1
brain 1
Ifx (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 317 100.00 Very High Very High Very High
Adalimumab 102 100.00 Very High Very High Very High
imagery 378 99.98 Very High Very High Very High
Etanercept 72 99.80 Very High Very High Very High
rheumatoid arthritis 152 99.64 Very High Very High Very High
dorsal root ganglion 59 99.08 Very High Very High Very High
Neuritis 10 99.06 Very High Very High Very High
positron emission tomography 160 98.64 Very High Very High Very High
Rheumatism 6 98.64 Very High Very High Very High
Demyelination 3 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 4809 100.00 Very High Very High Very High
Infection 944 100.00 Very High Very High Very High
Herpes Simplex Virus 88 100.00 Very High Very High Very High
Suicidal Behaviour 44 100.00 Very High Very High Very High
Sprains And Strains 334 99.96 Very High Very High Very High
Rheumatoid Arthritis 153 99.64 Very High Very High Very High
Colon Cancer 46 99.56 Very High Very High Very High
Immunization 113 99.46 Very High Very High Very High
Lysosome Storage Disease 80 99.32 Very High Very High Very High
Ganglion Cysts 81 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate the therapeutic efficacy of both lentiviral pseudotyoped vectors in the invasive xenograft model, vectors expressing the suicide gene HSV1-tk fused to eGFP were injected into established tumors when visible on MRI using the same method as described for the in vivo tropism study.
Gene_expression (expressing) of HSV1 associated with cold sores, suicidal behaviour and cancer
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707627 Disease Relevance 0.88 Pain Relevance 0
This life style led to the evolution of elaborate control mechanisms that coordinately regulate HSV-1 gene expression during latent and productive infection [1].


Gene_expression (expression) of HSV-1 associated with cold sores and infection
2) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.20 Pain Relevance 0.29
Current research on imaging HSV-1-tk gene expression is focusing on: 1) methods for exact quantification of HSV-1-TK expression, 2) improved HSV-1-TK probes for PET and SPECT, 3) translation of this imaging paradigm into other vector systems, 4) imaging follow-up in cancer therapy strategies, 5) imaging transcriptional activation, and 6) multimodal imaging by fusing the HSV-1-tk gene with further imaging genes.


Gene_expression (expression) of HSV-1 associated with cold sores, cancer, positron emission tomography and imagery
3) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.13 Pain Relevance 0.53
Current research on imaging HSV-1-tk gene expression is focusing on: 1) methods for exact quantification of HSV-1-TK expression, 2) improved HSV-1-TK probes for PET and SPECT, 3) translation of this imaging paradigm into other vector systems, 4) imaging follow-up in cancer therapy strategies, 5) imaging transcriptional activation, and 6) multimodal imaging by fusing the HSV-1-tk gene with further imaging genes.


Gene_expression (expression) of HSV-1 associated with cold sores, cancer, positron emission tomography and imagery
4) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.15 Pain Relevance 0.51
Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2.
Gene_expression (expressing) of HSV-1 in Optic associated with cold sores, optic neuritis, sprains and strains and neuritis
5) Confidence 0.75 Published 2009 Journal Invest. Ophthalmol. Vis. Sci. Section Title Doc Link 19234357 Disease Relevance 0.67 Pain Relevance 0.28
PURPOSE: The authors have shown previously that a recombinant HSV-1 that constitutively expresses two copies of murine IL-2 (HSV-IL-2) induces demyelination by activated CD8(+) T cells in the brain and spinal cord of ocularly infected female BALB/c mice.
Gene_expression (expresses) of HSV-1 in spinal cord associated with demyelination, cold sores and spinal cord
6) Confidence 0.75 Published 2009 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 19234357 Disease Relevance 0.61 Pain Relevance 0.25
We did, however, demonstrate in mice that immunization with CJ9-gD elicits strong HSV-specific CD4+ and CD8+ T-cell responses against HSV-1 and in a lesser extent against HSV-2 at levels similar or comparable to those induced by wild-type HSV-1 [27,29].
Gene_expression (responses) of HSV-1 in T-cell associated with cold sores and immunization
7) Confidence 0.65 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2889954 Disease Relevance 2.21 Pain Relevance 0
This finding, coupled with the unchanging abundance of LAT RNA indicate that changes in histone markers on the LAT and the IE regions of HSV-1 may be a crucial factor in in vivo reactivation.
Gene_expression (regions) of HSV-1 associated with cold sores
8) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.58 Pain Relevance 0
The investigators have demonstrated the capacity of HSV1716 virus expressing GUSB driven by the latency-associated transcript promoter (HSV-1716-LAT-GUSB virus) to correct the lysosomal storage in the adult MPS VII mouse model following intracranial injection.
Gene_expression (expressing) of HSV-1 associated with cold sores and lysosome storage disease
9) Confidence 0.65 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.01 Pain Relevance 0.11
Nonetheless, the fact that H3K4me2 enrichment of the ICP0 promoter does not change following TCIE does indicate that the changes in H3K4me2 enrichment that are observed following TCIE in the LAT region of HSV-1 strain McKrae are likely not due to global changes in chromatin following epinephrine stimulation.


Gene_expression (region) of HSV-1 associated with cold sores and sprains and strains
10) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.53 Pain Relevance 0
In order to answer this question and to begin to define the potential of epigenetic changes to the HSV-1 genome as a function of the reactivation process, we outlined studies with the following objectives: 1) to stimulate HSV-1 reactivation in an animal model using an efficient reactivation method not capable of directly modify histone tails; 2) to determine whether changes in the enrichment of a euchromatic histone marker could be observed for the LAT and IE regions of HSV-1 following reactivation stimuli; 3) to correlate any changes in the enrichments of euchromatic marks to LAT and lytic transcript abundance; and 4) to determine whether wild-type HSV-1 strains with different reactivation phenotypes established dissimilar profiles of euchromatic marker enrichments on the LAT and IE regions during latency and/or following the application of a reactivation stimulus.
Gene_expression (regions) of HSV-1 in tails associated with cold sores and sprains and strains
11) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.86 Pain Relevance 0
Time-dependent and spatial relationships of HSV-1-tk and lacZ gene co-expression in culture and in vivo indicate the potential for indirect in vivo imaging of therapeutic gene expression in tumour tissue infected with any recombinant HSV-1 vector where a therapeutic gene is substituted for the lacZ gene.
Gene_expression (expression) of HSV-1 associated with cold sores, cancer and imagery
12) Confidence 0.65 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.07 Pain Relevance 0.28
Previous studies identified changes in the acetyl-H3K9K14 associated with the LAT and IE regions of HSV-1 following the application of a reactivation stimulus in mice [19], [59].
Gene_expression (regions) of HSV-1 associated with cold sores
13) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.27 Pain Relevance 0
This result does suggest that dsRNA detection is a critical step in innate recognition of HSV-1 infection implicating TLR3 which is expressed in human neurons, microglia, and astrocytes [313].
Gene_expression (infection) of HSV-1 in astrocytes associated with cold sores and infection
14) Confidence 0.65 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.68 Pain Relevance 0.07
The investigators have demonstrated the capacity of HSV1716 virus expressing GUSB driven by the latency-associated transcript promoter (HSV-1716-LAT-GUSB virus) to correct the lysosomal storage in the adult MPS VII mouse model following intracranial injection.
Gene_expression (virus) of HSV-1 associated with cold sores and lysosome storage disease
15) Confidence 0.65 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.99 Pain Relevance 0.11
Degeneration of Scarpa's ganglion was observed in 4 of 5 mice that developed postural deviation, while HSV-1 antigens were found in 2 of them.
Gene_expression (found) of HSV-1 in Scarpa's ganglion associated with ganglion cysts and cold sores
16) Confidence 0.65 Published 1995 Journal Acta Otolaryngol Suppl Section Abstract Doc Link 7610901 Disease Relevance 0.57 Pain Relevance 0.15
The HSV-1 antigens were recognized exclusively in Scarpa's ganglion of the vestibular nerve in 2 of 4 mice in which signs of vestibular involvement were manifested.
Gene_expression (recognized) of HSV-1 in Scarpa's ganglion associated with ganglion cysts and cold sores
17) Confidence 0.65 Published 1993 Journal Acta Otolaryngol Suppl Section Abstract Doc Link 8385869 Disease Relevance 0.62 Pain Relevance 0.16
A second set was superinfected overnight with HSV-1 tsK.
Gene_expression (superinfected) of HSV-1 associated with cold sores
18) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2693105 Disease Relevance 0.41 Pain Relevance 0
In MC38/HSV1-Tk murine colon cancer cells, MCT had an IC5 of 2.9??
Gene_expression (/) of HSV1 in colon associated with cold sores and colon cancer
19) Confidence 0.65 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 1.05 Pain Relevance 0
The pathogenic effect of the vector virus in the mutants could be blocked by passive immunization with human gamma-globulin containing anti-HSV-1 antibodies on the day of infection but not when given at the peak of viral replication (day 4).
Gene_expression (containing) of HSV-1 associated with cold sores, immunization and infection
20) Confidence 0.65 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8972424 Disease Relevance 0.89 Pain Relevance 0.06

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