INT50227

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 5.17
Pain Relevance 12.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
brain 4
forebrain 2
blood 2
heart 2
plasma 1
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 921 100.00 Very High Very High Very High
agonist 875 100.00 Very High Very High Very High
Neuropathic pain 5 99.62 Very High Very High Very High
cINOD 2 99.60 Very High Very High Very High
Endep 6 99.46 Very High Very High Very High
Inflammation 29 99.34 Very High Very High Very High
Desipramine 12 99.10 Very High Very High Very High
Dopamine 62 99.04 Very High Very High Very High
antinociception 1 99.00 Very High Very High Very High
ischemia 62 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 214 100.00 Very High Very High Very High
Neuropathic Pain 19 99.62 Very High Very High Very High
Nociception 9 99.60 Very High Very High Very High
Mucositis 1 99.34 Very High Very High Very High
INFLAMMATION 29 98.88 Very High Very High Very High
Cv Unclassified Under Development 63 98.76 Very High Very High Very High
Reperfusion Injury 9 98.40 Very High Very High Very High
Coronary Artery Disease 10 96.84 Very High Very High Very High
Neuroblastoma 24 96.28 Very High Very High Very High
Pain 13 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This binding increases more slowly than receptor number, suggesting that the appearance of G proteins, rather than the A2AR, determines the developmental appearance of functional A2AR-G protein interactions in forebrain.
Positive_regulation (appearance) of A2AR in forebrain
1) Confidence 0.50 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.29
In forebrain the A2AR agonist-stimulated [35S]GTPgammaS binding increases rapidly after P7, reaching its highest levels at P21 and then declining slightly to adult levels.
Positive_regulation (agonist-stimulated) of A2AR in forebrain associated with agonist
2) Confidence 0.50 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.22
These studies 1) demonstrate the functional measurement of A2AR-G protein coupling in native tissue for the first time, 2) demonstrate that A2AR are coupled to G proteins throughout postnatal development, and 3) describe developmental increases and decreases in functional A2AR in brain.
Positive_regulation (coupled) of A2AR in brain
3) Confidence 0.50 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.22
These studies 1) demonstrate the functional measurement of A2AR-G protein coupling in native tissue for the first time, 2) demonstrate that A2AR are coupled to G proteins throughout postnatal development, and 3) describe developmental increases and decreases in functional A2AR in brain.
Positive_regulation (increases) of A2AR in brain
4) Confidence 0.50 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.21
The acute stimulation of adenylyl cyclase by activation of A2AR was markedly reduced in NG108-15 cells overexpressing wild-type GRK2.
Positive_regulation (activation) of A2AR in NG108-15
5) Confidence 0.44 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.11 Pain Relevance 0.21
In A5 cells, we found no evidence that alpha 2-AR activation decreases a resting Na+ conductance.
Positive_regulation (activation) of 2-AR
6) Confidence 0.39 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374765 Disease Relevance 0 Pain Relevance 0.40
In both cases, alpha 2-AR activation increases an inwardly rectifying K+ conductance.
Positive_regulation (activation) of 2-AR
7) Confidence 0.39 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374765 Disease Relevance 0 Pain Relevance 0.41
We interpret these findings as follows: 1) alpha 2-ARs in the RVLM are activated at rest, probably by catecholamines released by C1 adrenergic cells, 2) this activation reduces sSND, 3) DMI and amitriptyline reduce sSND by increasing alpha 2-AR activation in the RVLM, and 4) these effects are due to neither serotonin uptake inhibition nor blockade of norepinephrine uptake by noradrenergic fibers.
Positive_regulation (activation) of alpha 2-AR associated with desipramine, catecholamine, serotonin and endep
8) Confidence 0.39 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7611519 Disease Relevance 0 Pain Relevance 0.63
We interpret these findings as follows: 1) alpha 2-ARs in the RVLM are activated at rest, probably by catecholamines released by C1 adrenergic cells, 2) this activation reduces sSND, 3) DMI and amitriptyline reduce sSND by increasing alpha 2-AR activation in the RVLM, and 4) these effects are due to neither serotonin uptake inhibition nor blockade of norepinephrine uptake by noradrenergic fibers.
Positive_regulation (activation) of alpha 2-AR associated with desipramine, catecholamine, serotonin and endep
9) Confidence 0.39 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7611519 Disease Relevance 0 Pain Relevance 0.63
Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.
Positive_regulation (activation) of A2A adenosine receptor associated with adenocard, mucositis and inflammation
10) Confidence 0.38 Published 2009 Journal J. Gastroenterol. Section Title Doc Link 19333545 Disease Relevance 0.38 Pain Relevance 0.65
Finally, activation of the A1R/A2AR heteromer contributes to A2AR signaling when adenosine levels are elevated and may provide a mechanism to facilitate plastic changes in the excitatory synapse [18].


Positive_regulation (activation) of A2AR in synapse associated with adenocard
11) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.16 Pain Relevance 0.59
These results are in line with other studies indicating that adenosine downregulates excitatory and inhibitory synaptic transmission in several brain areas through activation of A1Rs and A2AR [97, 98].
Positive_regulation (activation) of A2AR in brain associated with adenocard
12) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.14 Pain Relevance 0.58
Several genes were identified as upregulated after 1 h of hypoxia including adenosine receptor A2AR, and another group of genes was increased after 6 h of hypoxia including VEGF, adrenomedullin, and GLUT-1.
Positive_regulation (upregulated) of A2AR associated with adenocard and hypoxia
13) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.07 Pain Relevance 0.18
This was probably caused by GRK2-dependent pre-desensitization of the A2AR by extracellular adenosine.
Positive_regulation (desensitization) of A2AR associated with adenocard
14) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.13 Pain Relevance 0.22
Indeed, the alpha 2A-AR transcript was present at mid-pregnancy, whereas high levels of alpha 2B-AR mRNA could be detected at term.
Positive_regulation (levels) of alpha 2B-AR
15) Confidence 0.30 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7738044 Disease Relevance 0 Pain Relevance 0.19
Low concentrations of the non-selective agonist NECA (0.3–3 nM), briefly exposed (5 min) to NTS brain slices, induced the release of 5-HT caused by the activation of the A2AR present at presynaptic nerves.
Positive_regulation (activation) of A2AR in brain associated with agonist
16) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.30
Lopes et al. investigated how activated A2AR influenced A1R function and whether this interaction was modified in aged rats.
Positive_regulation (activated) of A2AR
17) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.08 Pain Relevance 0.26
CGS21680 stimulation of a tagged A2AR transiently transfected in HEK293 cells induced the translocation of GFP-tagged arrestins 2 and 3 towards the plasma membrane.
Positive_regulation (stimulation) of A2AR in plasma
18) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.12 Pain Relevance 0.24
Within the scope of this review fits the observation that activation of the D2 receptor actually sensitizes A2AR-mediated increases in cAMP production, in CHO cells expressing both receptors [76] as well as in CAD and NS20Y neuroblastoma cells in which the D2 receptor was expressed [77].
Positive_regulation (increases) of A2AR-mediated in NS20Y associated with neuroblastoma and coronary artery disease
19) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.35 Pain Relevance 0.07
The authors investigated how electrically evoked [3H]dopamine (DA) and [14C]acetylcholine (ACh) release in the rat striatum is affected, directly or indirectly, by adenosine A1 and A2A receptor activation.
Positive_regulation (activation) of A2A in striatum associated with adenocard and dopamine
20) Confidence 0.28 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7902434 Disease Relevance 0 Pain Relevance 0.44

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