INT50228

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Context Info
Confidence 0.39
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.10
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
ileum 2
blood 2
neurons 2
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 43 100.00 Very High Very High Very High
Dopamine 12 100.00 Very High Very High Very High
Endep 6 99.68 Very High Very High Very High
Desipramine 12 99.32 Very High Very High Very High
agonist 45 98.62 Very High Very High Very High
MU agonist 4 98.14 Very High Very High Very High
Catecholamine 2 97.86 Very High Very High Very High
Serotonin 2 97.84 Very High Very High Very High
Kappa opioid receptor 4 91.44 High High
antagonist 33 90.84 High High
Disease Link Frequency Relevance Heat
Hypertension 2 98.64 Very High Very High Very High
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We interpret these findings as follows: 1) alpha 2-ARs in the RVLM are activated at rest, probably by catecholamines released by C1 adrenergic cells, 2) this activation reduces sSND, 3) DMI and amitriptyline reduce sSND by increasing alpha 2-AR activation in the RVLM, and 4) these effects are due to neither serotonin uptake inhibition nor blockade of norepinephrine uptake by noradrenergic fibers.
Positive_regulation (increasing) of Positive_regulation (activation) of alpha 2-AR associated with desipramine, catecholamine, serotonin and endep
1) Confidence 0.39 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7611519 Disease Relevance 0 Pain Relevance 0.64
We interpret these findings as follows: 1) alpha 2-ARs in the RVLM are activated at rest, probably by catecholamines released by C1 adrenergic cells, 2) this activation reduces sSND, 3) DMI and amitriptyline reduce sSND by increasing alpha 2-AR activation in the RVLM, and 4) these effects are due to neither serotonin uptake inhibition nor blockade of norepinephrine uptake by noradrenergic fibers.
Positive_regulation (increasing) of Positive_regulation (activation) of alpha 2-AR associated with desipramine, catecholamine, serotonin and endep
2) Confidence 0.39 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7611519 Disease Relevance 0 Pain Relevance 0.64
In contrast, the A2A receptor increases electrically induced twitch contractions in the guinea-pig ileum, which is attributed to facilitation of ACH release [13].
Positive_regulation (induced) of Positive_regulation (increases) of A2A receptor in ileum
3) Confidence 0.21 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.19
The results show that, at low concentrations (100 pm-1 nm), the mu-opioid agonist, Tyr-D-Ala-Gly-N-Me-Phe-glycinol (DAMGO), inhibits the increase in DARPP-32 phosphorylation induced by activation of D1, but not by activation of A2A receptors.
Positive_regulation (induced) of Positive_regulation (activation) of A2A associated with mu agonist
4) Confidence 0.11 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.70
The results show that, at low concentrations (100 pm-1 nm), the mu-opioid agonist, Tyr-D-Ala-Gly-N-Me-Phe-glycinol (DAMGO), inhibits the increase in DARPP-32 phosphorylation induced by activation of D1, but not by activation of A2A receptors.
Positive_regulation (activation) of Positive_regulation (activation) of A2A associated with mu agonist
5) Confidence 0.11 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.69
Conversely, the delta-receptor agonist, Tyr-D-Pen-Gly-Phe-D-Pen (DPDPE), inhibits DARPP-32 phosphorylation induced by activation of A2A, but not by activation of D1 receptors.
Positive_regulation (induced) of Positive_regulation (activation) of A2A associated with agonist
6) Confidence 0.11 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.72
In the striatum, DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) is highly expressed by virtually all projection medium-sized spiny neurons. cAMP-dependent phosphorylation of DARPP-32 is stimulated via activation of dopamine D1 receptors in striatonigral neurons, and via activation of adenosine A2A receptors in striatopallidal neurons.
Positive_regulation (stimulated) of Positive_regulation (activation) of A2A in neurons associated with adenocard and dopamine
7) Confidence 0.11 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.42
RESULTS: Local activation of the I1 receptor by rilmenidine (40 nmol) or by the I1/alpha2 receptor mixed agonist clonidine (1 nmol), and local activation of the alpha2-adrenergic receptor (alpha2AR) by the pure alpha2AR agonist alpha-methylnorepinephrine (alpha-MNE, 10 nmol) caused reductions in RVLM NE, and blood pressure.
Positive_regulation (activation) of Positive_regulation (activation) of alpha2AR in blood
8) Confidence 0.05 Published 2007 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 17374048 Disease Relevance 0.10 Pain Relevance 0

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