INT50230

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 105
Total Number 107
Disease Relevance 69.21
Pain Relevance 29.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
astrocytes 6
PGE2 4
BEAS-2B 4
corneal epithelial cells 4
lymphoid system 4
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1564 100.00 Very High Very High Very High
cytokine 1342 100.00 Very High Very High Very High
agonist 321 100.00 Very High Very High Very High
chemokine 143 100.00 Very High Very High Very High
fibrosis 97 100.00 Very High Very High Very High
Inflammatory mediators 67 100.00 Very High Very High Very High
Inflammatory response 179 99.92 Very High Very High Very High
Catecholamine 44 99.84 Very High Very High Very High
dexamethasone 173 99.70 Very High Very High Very High
substance P 73 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1880 100.00 Very High Very High Very High
Cancer 1078 100.00 Very High Very High Very High
Stress 675 100.00 Very High Very High Very High
Endometriosis 350 100.00 Very High Very High Very High
Adhesions 129 100.00 Very High Very High Very High
Necrosis 108 100.00 Very High Very High Very High
Cystic Fibrosis 30 100.00 Very High Very High Very High
Infection 245 99.98 Very High Very High Very High
Acute-phase Reaction 28 99.98 Very High Very High Very High
Multiple Myeloma 200 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevation of the plasma catecholamines immediately after SNP administration should also be taken into account, because an augmentation of the cAMP in various cell types has been proven to result in increased release of IL-6.
Positive_regulation (increased) of Localization (release) of IL-6 in plasma associated with catecholamine
1) Confidence 0.70 Published 1995 Journal Anaesthesist Section Abstract Doc Link 7611579 Disease Relevance 0.16 Pain Relevance 0.16
RESULTS: Wounded cells exposed to 5 J/cm(2) using 632.8 nm showed an increase in cell migration and haptotaxis, a stable increase in the release of interleukin-6 (IL-6), a decrease in caspase 3/7 activity, an increase in ATP viability and an increase in cell proliferation--1 h after the final exposure.
Positive_regulation (increase) of Localization (release) of IL-6
2) Confidence 0.69 Published 2008 Journal Photodermatol Photoimmunol Photomed Section Body Doc Link 18717961 Disease Relevance 0 Pain Relevance 0
In differentiated FLG 29.1 cells only IL-6 release was induced by catecholamine treatment.
Positive_regulation (induced) of Localization (release) of IL-6 associated with catecholamine
3) Confidence 0.65 Published 1996 Journal Osteoporos Int Section Abstract Doc Link 8845594 Disease Relevance 0 Pain Relevance 0.38
Adhesion of multiple myeloma cells to stromal cells triggers IL-6 secretion by the stromal cells [150].
Positive_regulation (triggers) of Localization (secretion) of IL-6 in stromal cells associated with multiple myeloma and adhesions
4) Confidence 0.60 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 2.83 Pain Relevance 0.51
Additional clues came from the observations that menopause or ovariectomy resulted in increased IL-6 serum levels [153], increased IL-6 mRNA levels in bone cells [154], and increased IL-6 secretion by mononuclear cells [155-157].
Positive_regulation (increased) of Localization (secretion) of IL-6 in mononuclear cells associated with endometriosis (extended)
5) Confidence 0.60 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.35 Pain Relevance 0.07
CONCLUSION: In the pancreas, FGF-2 may not only play a role as a growth factor in tissue injury repair processes but also as an inducer of acute-phase response via stimulation of IL-6 release.


Positive_regulation (stimulation) of Localization (release) of IL-6 in pancreas
6) Confidence 0.57 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF.
Positive_regulation (induced) of Localization (secretion) of IL-6
7) Confidence 0.55 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.11 Pain Relevance 0
production by HCE-T cells, but we did observe enhanced IL-6 secretion after 24 h of exposure.
Positive_regulation (enhanced) of Localization (secretion) of IL-6 in T cells
8) Confidence 0.51 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.47 Pain Relevance 0.12
Furthermore, prostaglandins can stimulate T98G to secrete interleukin-6, which in turn triggers the formation of additional prostaglandins.
Positive_regulation (stimulate) of Localization (secrete) of interleukin-6 in T98G
9) Confidence 0.50 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9845273 Disease Relevance 0.76 Pain Relevance 0.39
LPS-induced IL-6 and PGE2 release was only slightly inhibited at high doses, whereas LPS-induced release of IL-8 and matrix metalloprotease (MMP)-9 was not affected.
Positive_regulation (induced) of Localization (release) of IL-6
10) Confidence 0.49 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515409 Disease Relevance 0.50 Pain Relevance 0.19
participates in the innate acute inflammatory response by inducing the secretion of chemokines, which stimulate a second wave of cytokines, including IL-6, IL-8 and C-reactive protein [14,15].
Positive_regulation (inducing) of Localization (secretion) of IL-6 associated with chemokine, inflammatory response and cytokine
11) Confidence 0.49 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 1.08 Pain Relevance 0.37
They inferred that IL-6 release probably occurred through a route independent of the release of TNF-?
Positive_regulation (occurred) of Spec (probably) Localization (release) of IL-6
12) Confidence 0.49 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.33 Pain Relevance 0.17
Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.
Positive_regulation (potentiated) of Localization (release) of IL-6 in astrocytes associated with anaplastic astrocytoma
13) Confidence 0.49 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.60 Pain Relevance 0.30
Two human post-mortem astrocyte cultures (A157 and A295) and astroglioma cell lines (U251 and U373 MG) were found to secrete considerable amounts of IL-6 upon stimulation with IL-1beta.
Positive_regulation (stimulation) of Localization (secrete) of IL-6 in U373 MG associated with anaplastic astrocytoma
14) Confidence 0.49 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.98 Pain Relevance 0.51
RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation.
Positive_regulation (induced) of Localization (release) of IL-6
15) Confidence 0.48 Published 2009 Journal Aktuelle Urol Section Body Doc Link 19296424 Disease Relevance 0 Pain Relevance 0
These can go on over a prolonged period since (1) once released, VIP induces its own further secretion; (2) VIP induces release of interleukin-6 (IL6) that evokes both its own further release and release of VIP.
Positive_regulation (evokes) of Localization (release) of IL6
16) Confidence 0.47 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 18926642 Disease Relevance 1.12 Pain Relevance 0.48
Fas ligand stimulated IL-6 secretion (3.06 +/- 0.38 fmol/mg wet weight per 3 hours, P <.05).
Positive_regulation (stimulated) of Localization (secretion) of IL-6
17) Confidence 0.47 Published 2004 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15051033 Disease Relevance 0.12 Pain Relevance 0
It is well established that IL-6 can be derived from skeletal muscle and released into circulation following acute exercise [25], [26], [29].
Positive_regulation (derived) of Localization (released) of IL-6 in skeletal muscle
18) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.15 Pain Relevance 0
Immunofluorescent triple staining of Pax7, IL-6, and DAPI, revealed a substantial increase in the localization of IL-6 protein within SCs (see Fig.
Positive_regulation (increase) of Localization (localization) of IL-6
19) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
The rapid activation of tissue macrophages early in the innate immune response to infection causes the release of cytokines interleukin-6 (IL-6), interleukin-1?
Positive_regulation (causes) of Localization (release) of IL-6 in macrophages associated with infection and cytokine
20) Confidence 0.44 Published 2008 Journal Biological Psychiatry Section Body Doc Link PMC2885493 Disease Relevance 1.46 Pain Relevance 0.40

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