INT5025

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1982
Last Reported 2010
Negated 8
Speculated 3
Reported most in Abstract
Documents 63
Total Number 66
Disease Relevance 10.96
Pain Relevance 47.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
plasma 14
spinal 6
Peripheral nerve 6
brain 4
blood 4
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 482 100.00 Very High Very High Very High
Enkephalin 37 100.00 Very High Very High Very High
Opioid 36 100.00 Very High Very High Very High
Neuropeptide 24 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
Dopamine 12 100.00 Very High Very High Very High
Morphine 62 99.98 Very High Very High Very High
Dorsal horn 12 99.92 Very High Very High Very High
Endogenous opioid 24 99.80 Very High Very High Very High
electroacupuncture 12 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Exocrine Pancreatic Insufficiency 4 100.00 Very High Very High Very High
Shock 6 99.98 Very High Very High Very High
Pancreatitis 45 99.60 Very High Very High Very High
Urological Neuroanatomy 6 99.52 Very High Very High Very High
Lordosis 26 99.22 Very High Very High Very High
Dysesthesia 1 99.08 Very High Very High Very High
Ganglion Cysts 12 98.96 Very High Very High Very High
Congenital Anomalies 3 98.96 Very High Very High Very High
Neuropathic Pain 11 98.32 Very High Very High Very High
Epilepsy 10 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study demonstrated that repeated administration of morphine increased CCK gene expression in the amygdaloid complex, and suggested that the development of the tolerance to morphine analgesia is due, in part, to an increase in CCK activity in the amygdaloid complex.
Positive_regulation (increased) of Gene_expression (expression) of CCK associated with tolerance, cholecystokinin, analgesia and morphine
1) Confidence 0.70 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170343 Disease Relevance 0 Pain Relevance 1.50
These findings substantiate the hypothesis that long-term administration of opioid may induce a compensatory increase in CCK synthesis and/or release, which then results in a progressive antagonism of opioid analgesia.
Positive_regulation (increase) of Gene_expression (synthesis) of CCK associated with cholecystokinin, opioid and analgesia
2) Confidence 0.70 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170343 Disease Relevance 0 Pain Relevance 1.24
Interestingly, nonselective and delta-opiate receptor selective antagonists potentiated the estrogen-induced CCK mRNA expression in the medial preoptic nucleus.
Positive_regulation (induced) of Gene_expression (expression) of CCK mRNA in medial preoptic nucleus associated with antagonist, opiate and cholecystokinin
3) Confidence 0.70 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.17 Pain Relevance 1.22
The distribution of receptor internalization surrounds the distribution of CCK cells in the medial preoptic nucleus, suggesting that endogenous opioid peptides may modulate estrogen-induced CCK mRNA expression.
Positive_regulation (induced) of Gene_expression (expression) of CCK mRNA in medial preoptic nucleus associated with endogenous opioid and cholecystokinin
4) Confidence 0.70 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.24 Pain Relevance 1.36
Together, these results suggest that endogenous opioid peptides may modulate the estrogenic upregulation of CCK mRNA expression and demonstrate an important level of regulation of gene expression in which synaptic activity modifies hormonal input.
Positive_regulation (upregulation) of Gene_expression (expression) of CCK mRNA associated with endogenous opioid and cholecystokinin
5) Confidence 0.70 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.11 Pain Relevance 1.05
Furthermore, it is suggested that CCK may not play a significant role in the phenomenon of wind-up and central sensitization after repetitive C-fiber input under normal conditions or after axotomy, when expression of CCK and CCK-B receptors are increased in sensory neurons.
Positive_regulation (increased) of Gene_expression (expression) of CCK in sensory neurons associated with c fibre, central sensitization and cholecystokinin
6) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571648 Disease Relevance 0 Pain Relevance 0.83
EB treatment induced CCK mRNA expression in the central portion of the medial preoptic nucleus and posterodorsal medial amygdala at PND 20 and 25, respectively.
Positive_regulation (induced) of Gene_expression (expression) of CCK mRNA in amygdala associated with amygdala and cholecystokinin
7) Confidence 0.70 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9482232 Disease Relevance 0.14 Pain Relevance 0.59
Accelerated expression of cholecystokinin gene in the brain of rats rendered tolerant to morphine.
Positive_regulation (Accelerated) of Gene_expression (expression) of cholecystokinin gene in brain associated with cholecystokinin and morphine
8) Confidence 0.70 Published 1992 Journal Neuroreport Section Title Doc Link 1283533 Disease Relevance 0 Pain Relevance 0.88
Following spinal hemisection, CCK mRNA expression increased on the ipsilateral side at the spinal segments caudal to the injury and both sides of the spinal L4-5 segments without any significant changes in CCK(B) receptor mRNA levels.
Positive_regulation (increased) of Gene_expression (expression) of CCK mRNA in spinal associated with injury and cholecystokinin
9) Confidence 0.70 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19619609 Disease Relevance 0.73 Pain Relevance 1.17
Gene transfer of cholecystokinin corrected the increased susceptibility to audiogenic seizures and the high responses to analgesia for about one week.
Positive_regulation (transfer) of Gene_expression (transfer) of cholecystokinin associated with epilepsy, cholecystokinin and analgesia
10) Confidence 0.69 Published 1997 Journal Neuroscience Section Abstract Doc Link 9044370 Disease Relevance 0.43 Pain Relevance 0.85
The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion.
Positive_regulation (upregulated) of in peripheral nerve Gene_expression (expression) of cholecystokinin in primary sensory neurons associated with neuropeptide, opioid and cholecystokinin
11) Confidence 0.68 Published 2001 Journal Neuroreport Section Abstract Doc Link 11201090 Disease Relevance 0 Pain Relevance 0.61
In summary, T4 treatment had neither an independent nor an antagonistic effect on estrogen induced expression of CCK or PPE mRNA in the circuit.
Neg (neither) Positive_regulation (induced) of Gene_expression (expression) of CCK associated with cholecystokinin
12) Confidence 0.68 Published 1998 Journal Endocrinology Section Abstract Doc Link 9492057 Disease Relevance 0.07 Pain Relevance 0.32
These results indicate that endogenous opioids, acting on the delta-opiate receptor within nuclei of the limbic-hypothalamic circuit, restrain the estrogen-induced increase of cholecystokinin messenger RNA expression.
Positive_regulation (increase) of Gene_expression (expression) of cholecystokinin associated with endogenous opioid, opiate and cholecystokinin
13) Confidence 0.57 Published 1997 Journal Neuroscience Section Abstract Doc Link 9284350 Disease Relevance 0 Pain Relevance 1.25
We also observed that low line rats have elevated brain levels of cholecystokinin (CCK) in the cortex, which is consistent with literature showing that CCK content in the cortex is positively correlated with rates of aversive 22-kHz USVs.
Positive_regulation (elevated) of Gene_expression (levels) of CCK in cortex associated with cholecystokinin
14) Confidence 0.50 Published 2009 Journal Dev Psychobiol Section Abstract Doc Link 18819097 Disease Relevance 0.07 Pain Relevance 0.31
We also observed that low line rats have elevated brain levels of cholecystokinin (CCK) in the cortex, which is consistent with literature showing that CCK content in the cortex is positively correlated with rates of aversive 22-kHz USVs.
Positive_regulation (elevated) of Gene_expression (levels) of cholecystokinin in cortex associated with cholecystokinin
15) Confidence 0.50 Published 2009 Journal Dev Psychobiol Section Abstract Doc Link 18819097 Disease Relevance 0.07 Pain Relevance 0.31
Overflow of dopamine and cholecystokinin in rat nucleus accumbens in response to acute drug administration.
Positive_regulation (Overflow) of Gene_expression (Overflow) of cholecystokinin in nucleus accumbens associated with nucleus accumbens, dopamine and cholecystokinin
16) Confidence 0.50 Published 2000 Journal Synapse Section Title Doc Link 11020226 Disease Relevance 0 Pain Relevance 0.65
The display of lordosis behavior has been correlated with the estrogen-induced expression of cholecystokinin (CCK) and enkephalin within the limbic-hypothalamic circuit.
Positive_regulation (estrogen-induced) of Gene_expression (expression) of cholecystokinin associated with enkephalin, lordosis and cholecystokinin
17) Confidence 0.50 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.35 Pain Relevance 0.74
The display of lordosis behavior has been correlated with the estrogen-induced expression of cholecystokinin (CCK) and enkephalin within the limbic-hypothalamic circuit.
Positive_regulation (estrogen-induced) of Gene_expression (expression) of CCK associated with enkephalin, lordosis and cholecystokinin
18) Confidence 0.50 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.35 Pain Relevance 0.74
Furthermore, it is suggested that CCK may not play a significant role in the phenomenon of wind-up and central sensitization after repetitive C-fiber input under normal conditions or after axotomy, when expression of CCK and CCK-B receptors are increased in sensory neurons.
Positive_regulation (increased) of Gene_expression (expression) of CCK in sensory neurons associated with c fibre, central sensitization and cholecystokinin
19) Confidence 0.50 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571648 Disease Relevance 0 Pain Relevance 0.83
The results suggest that an acceleration of the expression of the CCK gene during long-term morphine treatment might constitute one of the mechanisms for morphine tolerance.
Positive_regulation (acceleration) of Gene_expression (expression) of CCK gene associated with tolerance and morphine
20) Confidence 0.50 Published 1992 Journal Neuroreport Section Abstract Doc Link 1283533 Disease Relevance 0 Pain Relevance 0.90

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox