INT50255

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1993
Last Reported 2011
Negated 4
Speculated 2
Reported most in Body
Documents 39
Total Number 41
Disease Relevance 29.73
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 18
macrophages 1
synovial fluid 1
plasma 1
lacrimal 1
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 260 100.00 Very High Very High Very High
aspirin 15 100.00 Very High Very High Very High
Inflammation 364 99.52 Very High Very High Very High
antagonist 20 99.48 Very High Very High Very High
allodynia 4 98.98 Very High Very High Very High
methotrexate 14 97.04 Very High Very High Very High
chemokine 68 97.00 Very High Very High Very High
Pain 8 96.92 Very High Very High Very High
Angina 5 96.68 Very High Very High Very High
cytokine 440 93.56 High High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 500 100.00 Very High Very High Very High
INFLAMMATION 398 100.00 Very High Very High Very High
Rheumatoid Arthritis 262 100.00 Very High Very High Very High
Alagille Syndrome 160 100.00 Very High Very High Very High
Targeted Disruption 160 99.98 Very High Very High Very High
Disease 359 99.84 Very High Very High Very High
Aging 108 99.68 Very High Very High Very High
Hepatitis C Virus Infection 210 99.64 Very High Very High Very High
Chlamydia Infection 105 99.40 Very High Very High Very High
Graft Vs Host Disease 13 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of CD4(+)CD28null T lymphocytes by tumor necrosis factor-alpha blockade in patients with unstable angina.
Regulation (Modulation) of CD4 in T lymphocytes associated with necrosis, angina and cancer
1) Confidence 0.49 Published 2006 Journal Circulation Section Title Doc Link 16682617 Disease Relevance 0.66 Pain Relevance 0.44
Our studies on chronic stress showed a significant increase in the relative proportion of circulating CD4+ and CD8+ cell subsets when the immobilization period was 2 hours per day.
Regulation (circulating) of CD4 associated with stress
2) Confidence 0.44 Published 2001 Journal BMC Immunol Section Body Doc Link PMC37547 Disease Relevance 0.85 Pain Relevance 0
Despite significant differences in the two compartments, patients with the largest population of CD4+CD28null T cells in the synovial fluid still tended to have the highest frequencies in peripheral blood (r = 0.47, P < 0.0001) (Figure 2b).
Regulation (population) of CD4 in synovial fluid
3) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.14 Pain Relevance 0.10
That CMI and antibodies interact in protection against Chlamydia was also emphasized by the finding that antibody-mediated protection is highly dependent on CD4+ T cell-mediated adaptive changes that occur in the local genital tract tissues during primary infection [53].
Regulation (dependent) of CD4 in T cell associated with chlamydia infection and infection
4) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.47 Pain Relevance 0
Since the MR1 mAb targets the interaction between CD4+ T cells and APCs, we next analyzed its effect on transferred HNT CD4+ T cells.
Spec (analyzed) Regulation (effect) of CD4 in MR1
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.07 Pain Relevance 0
Primed and targeted CD4+ T cells home to the ocular surface, causing damage to the lacrimal functional unit, an integrated system that includes the cornea, conjunctiva, and lacrimal gland.
Regulation (targeted) of CD4 in lacrimal associated with disorders of the lacrimal system
6) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 1.32 Pain Relevance 0.28
Repetitive PTx pre-treatment promotes development of CD4+CD25+FoxP3+ Treg
Regulation (development) of CD4
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.45 Pain Relevance 0.40
It is noteworthy that, although eventually five HCV patients were identified with the proper HLA-DP4 haplotype, they did not commonly exhibit the CD4+ T cell response against the defined peptides.
Neg (not) Regulation (response) of CD4 in T cell associated with hepatitis c virus infection
8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.29 Pain Relevance 0.04
Our study directly evidenced the specific CD4+ T cell responses against HCV F protein in transgenic mice following DNA immunization, and also in patients chronically infected with HCV.
Regulation (responses) of CD4 in T cell associated with targeted disruption, immunization and hepatitis c virus infection
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.56 Pain Relevance 0
HU had a cytopenic effect on the CD4+ cell count and blunted the CD4+ response to ABC/EFV/ddI.
Regulation (effect) of CD4
10) Confidence 0.34 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1090576 Disease Relevance 0.28 Pain Relevance 0
Our study evaluated the effect on CD4+ count of delayed HU treatment (until 8 weeks post-baseline) compared to HU treatment initiated at the start of the study.
Regulation (effect) of CD4
11) Confidence 0.34 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1090576 Disease Relevance 0.36 Pain Relevance 0
Moreover, we found no evidence for a direct role for CD4+ T cells in viral clearance although they may be important in supporting the development of CD8+ effector T cells [37,38,6].
Regulation (role) of CD4 in T cells
12) Confidence 0.31 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 1.10 Pain Relevance 0
HV68 infection results in polyclonal activation of B cells, characterized by an upregulation of the CD69 activation marker and an increase in nonspecific antibody production, a process that is dependent on CD4+ T cells [43,70,71].
Regulation (dependent) of CD4 in T cells associated with infection
13) Confidence 0.28 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.32 Pain Relevance 0.03
However, the effect of ASA on CD4(+)CD25(+)Foxp3(+) Treg cells has yet to be determined.
Regulation (effect) of CD4 associated with aspirin
14) Confidence 0.27 Published 2009 Journal Transpl. Immunol. Section Abstract Doc Link 19146957 Disease Relevance 0.29 Pain Relevance 0.48
Although these processes comprise a plethora of cells such as T cells, B cells, mast cells, and macrophages on the one hand and smooth muscle cells, fibroblasts, and airway epithelial cells on the other hand, over the last 15 years a subpopulation of CD4+ T cells emerged as key players in asthma pathogenesis—the T helper 2 (TH2) cell.
Regulation (subpopulation) of CD4 in macrophages associated with asthma
15) Confidence 0.26 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.73 Pain Relevance 0.13
Recently, a group led by Miller showed that CD4+ T cells from old mice, which are the most affected by the aging process, have defects in their activation process and a deficiency in the formation of immunosynapses during stimulation by antigen-presenting cells.
Regulation (affected) of CD4 in T cells associated with aging
16) Confidence 0.26 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.32 Pain Relevance 0.03
Blood CD4+ T cells from patients with rheumatoid arthritis (RA) contained higher levels of SOCS1 but lower levels of SOCS3 mRNA than control CD4+ T cells, as determined by real-time polymerase chain reaction [73].
Regulation (control) of CD4 in T cells associated with rheumatoid arthritis
17) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.12 Pain Relevance 0.59
The lack of CD28 expression on CD4+ T cells is a very unusual feature for the mature CD4 T cell.
Regulation (lack) of CD4 in T cells
18) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165060 Disease Relevance 1.05 Pain Relevance 0.22
CD4+ T cells can also be affected, in particular in patients with autoimmune conditions.
Regulation (affected) of CD4 in T cells
19) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.45 Pain Relevance 0
It also has a chemoattractant effect of CD4+ and CD8+ T lymphocytes [35].
Regulation (effect) of CD4 in T lymphocytes
20) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.67 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox