INT50267

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 25 100.00 Very High Very High Very High
Clonidine 6 99.98 Very High Very High Very High
excitatory amino acid 1 97.96 Very High Very High Very High
monoamine 10 85.44 High High
Glutamate 7 82.52 Quite High
agonist 33 79.56 Quite High
antagonist 4 78.16 Quite High
Inflammation 2 67.16 Quite High
Analgesic 1 66.28 Quite High
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 15 99.82 Very High Very High Very High
Toxicity 8 94.24 High High
Death 2 86.40 High High
Disease 17 73.80 Quite High
Drug Induced Neurotoxicity 3 72.08 Quite High
INFLAMMATION 7 67.16 Quite High
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, the MPTP-induced loss of tyrosine hydroxylase immunoreactivity in nigral cell bodies was nearly completely prevented by the higher dose of sodium salicylate.
Negative_regulation (prevented) of Negative_regulation (loss) of tyrosine hydroxylase associated with parkinson's disease
1) Confidence 0.42 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10543426 Disease Relevance 0.64 Pain Relevance 0.19
Clonidine suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced reductions of striatal dopamine and tyrosine hydroxylase activity in mice.
Negative_regulation (suppresses) of Negative_regulation (reductions) of tyrosine hydroxylase associated with dopamine and clonidine
2) Confidence 0.40 Published 1995 Journal J. Neurochem. Section Title Doc Link 7616226 Disease Relevance 0.78 Pain Relevance 0.79
Importantly, in animals receiving 2R,4R-APDC post lesion, NeuN+ and TH+ cell loss was attenuated in parallel in the ipsilateral SNc, strongly supporting a neuroprotective effect, rather than alterations in TH expression in atrophic neurones.
Negative_regulation (attenuated) of Negative_regulation (loss) of TH
3) Confidence 0.25 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

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