INT50268

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Context Info
Confidence 0.65
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 10.73
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FBN1) extracellular region (FBN1) proteinaceous extracellular matrix (FBN1)
Anatomy Link Frequency
capsule 2
joints 1
lymph node 1
colon 1
T-cell 1
FBN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 54 99.96 Very High Very High Very High
metalloproteinase 76 99.48 Very High Very High Very High
Inflammation 132 99.12 Very High Very High Very High
cytokine 133 98.60 Very High Very High Very High
nud 1 97.84 Very High Very High Very High
abdominal pain 1 97.32 Very High Very High Very High
Arthritis 206 96.48 Very High Very High Very High
endometriosis 5 94.44 High High
Sciatica 4 87.48 High High
chemokine 18 84.56 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 105 100.00 Very High Very High Very High
Cancer 218 99.26 Very High Very High Very High
INFLAMMATION 157 99.12 Very High Very High Very High
Syndrome 6 98.24 Very High Very High Very High
Disease 129 98.20 Very High Very High Very High
Dyspepsia 1 97.84 Very High Very High Very High
Abdominal Pain 1 97.32 Very High Very High Very High
Juvenile Chronic Polyarthritis 180 96.48 Very High Very High Very High
Endometriosis (extended) 5 94.44 High High
Injury 126 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evaluation revealed a cul-de-sac mass and CA-125 level of 1048 U/ml.
Gene_expression (level) of mass
1) Confidence 0.65 Published 2009 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 19899417 Disease Relevance 1.05 Pain Relevance 0.39
These findings are characteristic alterations of the MFs produced by chronic low-grade compression.
Gene_expression (produced) of MFs
2) Confidence 0.52 Published 1995 Journal J. Neurosurg. Section Abstract Doc Link 7616282 Disease Relevance 0.47 Pain Relevance 0.31
Fibrillin 1 is expressed exclusively in vascular SMCs while fibrillin 2 is found also in colon SMCs (Figure 2B).
Gene_expression (expressed) of Fibrillin 1 in colon
3) Confidence 0.29 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.13 Pain Relevance 0.06
The differential expression of fibrillin 1 and fibrillin 2 in SMCs may be related to the anatomic specificity of diseases that result from defects of these proteins.
Gene_expression (expression) of fibrillin 1 associated with disease
4) Confidence 0.29 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.03 Pain Relevance 0.07
Mutations in fibrillin 1 lead to Marfan's syndrome, in which major defects affect the vascular structures, in agreement with vascular SMC expression of fibrillin-1 (Figure 2B).
Gene_expression (expression) of fibrillin-1 associated with syndrome
5) Confidence 0.26 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.91 Pain Relevance 0.03
FBN, also representative of the EMT transition [38] is overexpressed in our metastatic samples.
Gene_expression (overexpressed) of FBN
6) Confidence 0.25 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.10 Pain Relevance 0.03
Fibrillin can be detected in the synovial lining of joints in health and disease [45].
Gene_expression (detected) of Fibrillin in joints associated with disease
7) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.16 Pain Relevance 0.47
The peptides derived from aggrecan, fibrillin, and matrix metalloproteinase (MMP)-3 yielded the highest frequency of T-cell proliferative responses in JIA patients.
Gene_expression (derived) of fibrillin in T-cell associated with metalloproteinase and arthritis
8) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794523 Disease Relevance 1.09 Pain Relevance 0.67
In contrast, uPA expression levels were not significantly different between breast cancers (data not shown; Mann-Whitney p = 0.09 and p = 0.11 for MFS and BCS, respectively).


Gene_expression (expression) of MFS associated with breast cancer
9) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.53 Pain Relevance 0
As shown in Table 3, tumor size, age categories and PAI-1 mRNA expression are of prognostic value for MFS while lymph node status, histological type, histological grade and uPA expression did not add significant independent prognostic information.
Gene_expression (expression) of MFS in lymph node associated with cancer
10) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.81 Pain Relevance 0
Although it has been previously described that normal elbow capsules can be obtained from organ donors [7] for limited resources, we did not take capsules of organ donors as a source of MFs for our functional experiments.
Gene_expression (source) of MFs in capsules
11) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.14 Pain Relevance 0.18
Here, we could clearly show that human joint capsule MFs express COX2 under in vitro conditions (Figure 7a, b) and significantly upregulate synthesis of PGE2 (Figure 7c), but not PGF1A and PGF2A, upon TNF-?
Gene_expression (express) of MFs in capsule associated with cox2
12) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.15 Pain Relevance 0.23
With regard to HSC/MFs, MCP-1 expression is stimulated by pro-inflammatory cytokines, such as IL-1 and TNF [282,283], thrombin [285], engagement of integrin receptors [285] and both ROS and HNE [273,286].
Gene_expression (expression) of MFs associated with inflammation and cytokine
13) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.79 Pain Relevance 0.29
The first published study in 1993 [300] was on human HSC/MFs exposed to very low levels of HNE (1 ?
Gene_expression (exposed) of MFs
14) Confidence 0.00 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.37 Pain Relevance 0

General Comments

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