INT50290

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Context Info
Confidence 0.27
First Reported 1995
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 29
Total Number 34
Disease Relevance 17.19
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
poly 1
neurons 1
brain 1
organ systems 1
corpus luteum 1
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 98 99.98 Very High Very High Very High
dorsal root ganglion 148 99.96 Very High Very High Very High
Inflammation 297 99.52 Very High Very High Very High
cytokine 293 99.28 Very High Very High Very High
aspirin 77 99.28 Very High Very High Very High
cINOD 257 99.18 Very High Very High Very High
Analgesic 23 97.98 Very High Very High Very High
tricyclic antidepressant 3 97.16 Very High Very High Very High
chemokine 12 96.72 Very High Very High Very High
Inflammatory response 43 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 296 100.00 Very High Very High Very High
Ganglion Cysts 149 99.96 Very High Very High Very High
Pancreatic Cancer 84 99.84 Very High Very High Very High
Hepatic Porphyrias 1 99.72 Very High Very High Very High
INFLAMMATION 434 99.52 Very High Very High Very High
Disease 529 99.48 Very High Very High Very High
Hereditary Coproporphyria 2 99.36 Very High Very High Very High
Breast Cancer 60 99.34 Very High Very High Very High
Parkinson's Disease 282 99.04 Very High Very High Very High
Apoptosis 79 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations prompted us to address the possibility that the failure to detect a benefit from estrogen might be partly attributable to a pharmacodynamic interaction with inhibitors of COX-2, the major source of PGI2 in vivo.
COX Spec (might) Binding (interaction) of
1) Confidence 0.27 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.78 Pain Relevance 0.21
CONCLUSIONS: Our results explicitly indicate the synergistic nature of the interaction between NOS and COX inhibitors in formalin-induced nociceptive behavior in mice, and provide an alternative approach for controlling pain.


COX Binding (interaction) of
2) Confidence 0.27 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292449 Disease Relevance 0.06 Pain Relevance 0
BACKGROUND: An interaction between nitric oxide (NO) and cyclooxygenases (COX) in the production of prostaglandins in carrageenan-induced inflammation has been established.
COX Binding (interaction) of associated with inflammation
3) Confidence 0.26 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18292449 Disease Relevance 0.26 Pain Relevance 0.30
The present study raises the possibility of a drug–drug interaction with cardiovascular implications involving COX inhibitors.
COX Binding (interaction) of
4) Confidence 0.21 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.89 Pain Relevance 0.21
Thus, the interaction between COX inhibitors and HT appeared to be specific.
COX Spec (appeared) Binding (interaction) of
5) Confidence 0.20 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.13 Pain Relevance 0.32
As the production of eicosanoids in addition to PGE2 is also inhibited by celecoxib, and as celecoxib has COX-independent interactions, its effects on tumor formation may vary in different organ systems.
COX Binding (interactions) of in organ systems associated with cancer
6) Confidence 0.20 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12376474 Disease Relevance 0.73 Pain Relevance 0.13
These data thus indicate that potent analgesic activity of mofezolac against the present model to be more closely related to its potent inhibitory activity against COX-1 but not against COX-2.
COX Binding (activity) of associated with analgesic
7) Confidence 0.18 Published 1998 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 9777656 Disease Relevance 0.23 Pain Relevance 0.54
These data thus indicate that potent analgesic activity of mofezolac against the present model to be more closely related to its potent inhibitory activity against COX-1 but not against COX-2.
COX Binding (activity) of associated with analgesic
8) Confidence 0.18 Published 1998 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 9777656 Disease Relevance 0.23 Pain Relevance 0.54
Although coupling between COX-2 and mitochondrial enzymes in brain has not been reported, mitochondrial localization of COX-2 has been reported in cancer cells and in corpus luteum [12,13].
COX Binding (coupling) of in corpus luteum associated with cancer
9) Confidence 0.15 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.10 Pain Relevance 0.15
COX inhibitors can exert their anti-inflammatory activities by blocking the NF-?
COX Binding (exert) of associated with inflammation
10) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697669 Disease Relevance 1.34 Pain Relevance 0.40
Although some of the molecular mechanisms underlying these changes are not well understood at this time, these data identify metabolic and signaling pathways that were previously not known to be affected by COX.
COX Binding (affected) of
11) Confidence 0.13 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.25 Pain Relevance 0.33
In contrast to other NSAIDs, such as indomethacin, which reversibly bind at the COX active site [7], aspirin causes an irreversible inhibition of PGHS by rapidly and selectively acetylating the hydroxyl group of a serine residue (Ser 530) near the C-terminus of the enzyme, forming an impediment to the binding of AA [8-10].
COX Binding (bind) of associated with aspirin and cinod
12) Confidence 0.13 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0.36 Pain Relevance 0.70
To selectively design out the COX inhibitory activity of sulindac sulfide (SS), in silico modeling studies were done that revealed the crucial role of the carboxylate moiety for COX-1 and COX-2 binding.
COX Binding (binding) of
13) Confidence 0.13 Published 2009 Journal Cancer Prev Res (Phila Pa) Section Abstract Doc Link 19470791 Disease Relevance 0.53 Pain Relevance 0.08
To selectively design out the COX inhibitory activity of sulindac sulfide (SS), in silico modeling studies were done that revealed the crucial role of the carboxylate moiety for COX-1 and COX-2 binding.
COX Binding (binding) of
14) Confidence 0.13 Published 2009 Journal Cancer Prev Res (Phila Pa) Section Abstract Doc Link 19470791 Disease Relevance 0.53 Pain Relevance 0.08
Genotyping of COX-2-deficient mice
COX Binding (Genotyping) of
15) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.49 Pain Relevance 0
We determined the X-ray structure of resveratrol bound to COX-1 and demonstrate that it occupies the COX active site similar to other NSAIDs (non-steroidal anti-inflammatory drugs).
COX Spec (determined) Binding (bound) of associated with inflammation and cinod
16) Confidence 0.11 Published 2010 Journal Biochem. J. Section Abstract Doc Link 20450491 Disease Relevance 0.21 Pain Relevance 0.19
Therefore, COX-2 may serve as a potential target for the development of therapeutic strategies to treat the progressive cell loss observed in PD.


COX Binding (target) of associated with disease
17) Confidence 0.11 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.90 Pain Relevance 0.19
We found COX-1 expressed in microglia, some of them in close proximity to L-PGDS-positive oligodendrocytes and co-localization of COX-1 with L-PGDS in perivascular and leptomeningeal cells under control conditions.
COX Binding (found) of in oligodendrocytes
18) Confidence 0.11 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.30 Pain Relevance 0.30
The recent determination of the crystal structure of diclofenac complexed with COX-2 demonstrates that diclofenac binds to COX-2 in an inverted conformation with its carboxylate group being hydrogen-bonded to Tyr-385 and Ser-530, a feature consistent with the structure of the complex arachidonic acid-apoCOX-2 [31].
COX Binding (binds) of associated with diclofenac
19) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0 Pain Relevance 0.27
Treatment with the nonselective cyclooxygenase (COX) inhibitor carprofen prevents poly(I ? 
COX Binding (Treatment) of in poly
20) Confidence 0.09 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.46 Pain Relevance 0.22

General Comments

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