INT50295

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Context Info
Confidence 0.26
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.54
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
neurons 2
RAG 1
nerve 1
fibroblast 1
basement membrane 1
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 19 100.00 Very High Very High Very High
Pain 25 99.98 Very High Very High Very High
agonist 65 99.92 Very High Very High Very High
bDMF 36 99.92 Very High Very High Very High
Angina 1 99.84 Very High Very High Very High
cINOD 6 99.56 Very High Very High Very High
Inflammation 56 97.96 Very High Very High Very High
Brush evoked pain 3 97.60 Very High Very High Very High
Inflammatory response 38 97.40 Very High Very High Very High
Potency 17 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 17 99.98 Very High Very High Very High
Cv General 3 Under Development 1 99.84 Very High Very High Very High
Death 45 99.32 Very High Very High Very High
Nociception 17 99.00 Very High Very High Very High
Congenital Anomalies 1 98.66 Very High Very High Very High
Injury 148 98.52 Very High Very High Very High
INFLAMMATION 92 97.96 Very High Very High Very High
Neuropathic Pain 7 97.60 Very High Very High Very High
Embryonic Lethality 1 97.22 Very High Very High Very High
Apoptosis 107 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antiproliferation/antiprogression activities include modulation of signal transduction (glycyrrhetinic acid, NSAIDs, polyphenols, retinoids, tamoxifen), modulation of hormonal and growth factor activity (NSAIDs, retinoids, tamoxifen), inhibition of aberrant oncogene activity (genistein, NSAIDs, monoterpenes), inhibition of polyamine metabolism (DFMO, retinoids, tamoxifen), induction of terminal differentiation (calcium, retinoids, vitamin D3), restoration of immune response (NSAIDs, selenium, vitamin E), enhancing intercellular communication (carotenoids, retinoids), restoration of tumor suppressor function, induction of programmed cell death (apoptosis) (butyric acid, genistein, retinoids, tamoxifen), correction of DNA methylation imbalances (folic acid), inhibition of angiogenesis (genistein, retinoids, tamoxifen), inhibition of basement membrane degradation (protease inhibitors), and activation of antimetastasis genes.
Regulation (modulation) of growth factor in basement membrane associated with cancer, cinod and apoptosis
1) Confidence 0.26 Published 1994 Journal J. Cell. Biochem. Suppl. Section Abstract Doc Link 7616736 Disease Relevance 0.25 Pain Relevance 0.55
One such mechanism, the progesterone specific regulation of the growth factor, neuregulin-1, following nerve root injury in the rat, is described in detail.
Regulation (regulation) of growth factor in nerve associated with injury
2) Confidence 0.22 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18394805 Disease Relevance 0.67 Pain Relevance 0.47
Sex-specific pain modulation: the growth factor, neuregulin-1, as a pro-nociceptive cytokine.
Regulation (modulation) of growth factor associated with nociception, pain and cytokine
3) Confidence 0.22 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18394805 Disease Relevance 0.63 Pain Relevance 0.74
Our understanding of growth factor regulation by sex steroids promises to open up new avenues of investigation into the mechanisms that drive sex differences in pain sensitivity.
Regulation (regulation) of growth factor associated with pain
4) Confidence 0.19 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18394805 Disease Relevance 0.71 Pain Relevance 0.49
Targeting vascular endothelial growth factor in angina therapy.
Regulation (Targeting) of growth factor associated with angina
5) Confidence 0.09 Published 2006 Journal Expert Opin. Ther. Targets Section Title Doc Link 16441224 Disease Relevance 0.10 Pain Relevance 0.10
LKB1-deficient mice undergo embryonic lethality during the midgestational period, showing severe vascular abnormalities due to defective vasculogenesis associated with a tissue-specific deregulation of vascular endothelial growth factor.7) Overexpression of wild-type LKB1 in vitro induces a G1 cell cycle arrest and suppresses growth in tumor cell lines.
Regulation (deregulation) of growth factor associated with cancer, congenital anomalies and embryonic lethality
6) Confidence 0.03 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.62 Pain Relevance 0
This hypergeometric analysis indicates that the 4.1 fold greater enrichment in the RAG/CsNp genes was highly significant (p = 0.000015) whereas there was no overall change in growth factor receptor genes (-1.1 fold, p = .42) and significantly fewer genes were found in the apoptosis gene group than expected by chance alone (-2.2 fold, p = .02).
Neg (no) Regulation (change) of growth factor in RAG associated with apoptosis
7) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.66 Pain Relevance 0
An up-regulation of several growth factor receptors, as well as a down-regulation of receptors to several factors that inhibit axonal growth may indicate potential therapeutic treatments to protect TPS neurons from early cell death post-axotomy and to maximize and sustain the early regenerative response.


Regulation (regulation) of growth factor in neurons associated with death
8) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.72 Pain Relevance 0.09
Recent data suggest a relation between growth factor-mediated dysregulation of glucose and protein metabolism due to systemic inflammation and the development of myopathy [13,14].
Regulation (dysregulation) of growth factor-mediated associated with inflammation and muscle disease
9) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 1.53 Pain Relevance 0.20
Compared with no growth factor controls, GDNF, at 1 and 100 ng/ml, significantly increased by nearly 100% the number of neurons in culture at 5 days post-plating.
Neg (no) Regulation (controls) of growth factor in neurons
10) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC548274 Disease Relevance 0.53 Pain Relevance 0.63
agonists to modulate Transforming Growth Factor-?
Regulation (modulate) of Growth Factor associated with agonist
11) Confidence 0.01 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.34
The effect of various cytokines and osteoinductive growth factors, such as BMP-2, BMP-7, or rhBMP-12, TGF-beta1, TGF-beta2, TGF-beta3, and fibroblast growth factor, have been tested for TBI healing enhancement.
Regulation (effect) of growth factor in fibroblast associated with cytokine
12) Confidence 0.01 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2931497 Disease Relevance 0.08 Pain Relevance 0.10
Among the best known CREB transcriptional targets is the growth factor, BDNF, which was shown in our study to also be elevated by EDC.
Regulation (targets) of growth factor associated with bdmf
13) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.05 Pain Relevance 0.08

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