INT50300

Context Info Confidence 0.26 First Reported 1995 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.11

extracellular space (Igf1, Ghrh) extracellular region (Igf1, Ghrh)

Igf1 (Rattus norvegicus) Ghrh (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 6 100.00 Clonidine 1 25.00 agonist 1 25.00

Disease Link Frequency Relevance Heat Body Weight 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We propose that these studies suggest that endogenous hypothalamic IGF-I mediates the influence of GH in the feedback mechanism by increasing SRIF and depressing GRF release.

IGF-I Positive_regulation (mediates) of Gene_expression (depressing) of GRF associated with somatostatin

1) Confidence 0.26 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0 Pain Relevance 0.11

General Comments

This test has worked.