INT50308

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 5
Speculated 5
Reported most in Abstract
Documents 61
Total Number 66
Disease Relevance 14.41
Pain Relevance 33.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
brain 6
nucleus accumbens 3
hypothalamus 3
neurons 3
superior 2
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 424 100.00 Very High Very High Very High
agonist 297 100.00 Very High Very High Very High
antagonist 253 100.00 Very High Very High Very High
Endocannabinoid 252 100.00 Very High Very High Very High
Cannabinoid receptor 157 100.00 Very High Very High Very High
Glutamate 64 100.00 Very High Very High Very High
Opioid 50 100.00 Very High Very High Very High
narcan 30 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 131 99.90 Very High Very High Very High
Nociception 96 99.68 Very High Very High Very High
Anxiety Disorder 313 99.44 Very High Very High Very High
Cognitive Disorder 29 99.00 Very High Very High Very High
Pain 188 98.88 Very High Very High Very High
Recurrence 8 98.84 Very High Very High Very High
Dyspepsia 62 98.52 Very High Very High Very High
Colitis 8 98.08 Very High Very High Very High
Hypothermia 7 96.92 Very High Very High Very High
Stress 284 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, VUF5420 showed very low affinity (Kd approximately 10 microM) on CB1-receptor activation of 35S-GTPgammaS binding, indicating that this drug does not directly interact with the CB1 receptor in vivo.
CB1 Neg (not) Binding (interact) of
1) Confidence 0.48 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806300 Disease Relevance 0.08 Pain Relevance 1.36
However, as it binds to the cannabinoid receptors (CB1) only at high concentrations, it is not considered an actual endocannabinoid.
CB1 Binding (binds) of associated with endocannabinoid and cannabinoid receptor
2) Confidence 0.48 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193744 Disease Relevance 0.10 Pain Relevance 0.30
Early molecular modeling studies with Delta9-tetrahydrocannabinol (Delta9-THC) reported that three discrete regions which interact with brain cannabinoid (CB1) receptors corresponded to the C-9 position of the cyclohexene ring, the phenolic hydroxyl and the carbon side chain at the C3 position.
CB1 Binding (interact) of in brain associated with cannabinoid
3) Confidence 0.48 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618400 Disease Relevance 0 Pain Relevance 0.20
Clozapine decreases [3H] CP 55940 binding to the cannabinoid 1 receptor in the rat nucleus accumbens.
cannabinoid 1 receptor Binding (binding) of in nucleus accumbens associated with nucleus accumbens, analgesic and cannabinoid
4) Confidence 0.48 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 15995876 Disease Relevance 0.26 Pain Relevance 0.56
The effect of anaesthesia on [(18)F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain.
type 1 cannabinoid receptor Binding (binding) of in brain associated with anesthesia and cannabinoid receptor
5) Confidence 0.48 Published 2010 Journal Eur. J. Nucl. Med. Mol. Imaging Section Title Doc Link 20182714 Disease Relevance 0.10 Pain Relevance 0.28
Signal transduction interactions between CB1 cannabinoid and dopamine receptors in the rat and monkey striatum.
CB1 Binding (interactions) of in striatum associated with analgesic, dopamine receptor and cannabinoid
6) Confidence 0.47 Published 2001 Journal Neuropharmacology Section Title Doc Link 11378162 Disease Relevance 0 Pain Relevance 0.48
In summary, the unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons originated a marked increase in CB1 receptor-mRNA levels in cell bodies of striatal efferent neurons, although accompanied by no changes in CB1 receptor binding and activation of signal transduction mechanisms.
CB1 Binding (binding) of in dopaminergic neurons
7) Confidence 0.45 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.12
These molecules bind to the CB1 cannabinoid receptor on presynaptic axon terminals to regulate ion channel activity and inhibit neurotransmitter release [7].
CB1 Binding (bind) of associated with neurotransmitter and cannabinoid receptor
8) Confidence 0.45 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2957172 Disease Relevance 0.94 Pain Relevance 0.33
Under these experimental conditions, binding to cannabinoid (CB1R) and vanilloid (TRPV1) receptor was assessed with rapid-filtration assays.
CB1R Binding (binding) of
9) Confidence 0.44 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
Collectively, these results indicate that cannabinoids reduce inflammation via interaction with a peripheral CB1 receptor.
CB1 receptor Binding (interaction) of associated with inflammation and cannabinoid
10) Confidence 0.44 Published 1998 Journal Pain Section Abstract Doc Link 9539680 Disease Relevance 0.63 Pain Relevance 1.12
Our results indicate that cannabinoids produce antihyperalgesia via interaction with a peripheral CB1 receptor.
CB1 receptor Binding (interaction) of associated with cannabinoid
11) Confidence 0.44 Published 1998 Journal Pain Section Abstract Doc Link 9539680 Disease Relevance 0.80 Pain Relevance 1.19
In the present study, we assessed whether VR1 is involved in neuroprotection by AEA and by arvanil, a hydrolysis-stable AEA analog that is a ligand for both VR1 and CB1.
CB1 Binding (ligand) of associated with cannabinoid
12) Confidence 0.43 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764100 Disease Relevance 0.05 Pain Relevance 0.28
Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core.
CB1 Binding (Interactions) of in nucleus accumbens associated with nucleus accumbens, neurotransmitter, cannabinoid, narcan and mu opioid receptor
13) Confidence 0.43 Published 2006 Journal Neuropharmacology Section Title Doc Link 16806307 Disease Relevance 0 Pain Relevance 1.12
It is proposed that these allosterically interacting mu and CB1 receptors in the NAc core may represent G-protein coupled heterodimeric receptor complexes.
CB1 Binding (interacting) of
14) Confidence 0.43 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806307 Disease Relevance 0 Pain Relevance 1.05
We examined the occurrence of functional interactions between CB1 cannabinoid and mu opioid receptors in the core of rat nucleus accumbens (NAc core).
CB1 Spec (examined) Binding (interactions) of in nucleus accumbens associated with nucleus accumbens, cannabinoid and mu opioid receptor
15) Confidence 0.43 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806307 Disease Relevance 0 Pain Relevance 0.75
Upon resolution, the latter provided a pair of enantiomers: (-)-CP-55,244 was approximately 3-fold more potent than the racemic mixtures, and (+)-CP-55,244 failed to bind to the CB1 receptor with an IC50 below 1 mM.
CB1 receptor Neg (failed) Binding (bind) of
16) Confidence 0.42 Published 1995 Journal Drug Des Discov Section Abstract Doc Link 8872458 Disease Relevance 0 Pain Relevance 0.46
This study demonstrates that the potency could be optimized in (-)-CP-55,244 for both binding to the CB1 receptor and the biological activity of analgesia.
CB1 receptor Binding (binding) of associated with analgesia and potency
17) Confidence 0.42 Published 1995 Journal Drug Des Discov Section Abstract Doc Link 8872458 Disease Relevance 0 Pain Relevance 0.53
We examined the interaction of both compounds with cannabinoid receptors (CB1 and CB2) and their efficacy in functional assays.
CB1 Spec (examined) Binding (interaction) of associated with cannabinoid receptor
18) Confidence 0.39 Published 2005 Journal Life Sci. Section Abstract Doc Link 15894337 Disease Relevance 0.06 Pain Relevance 0.31
Recent data indicate a protective function of up-regulated endocannabinoid levels in colitis.38,27 In rats and guinea pigs, besides an expression in cholinergic myenteric neurons, a close association between CB1R immunoreactivity and fibers labeled for a synaptic protein has been described, suggesting a role in the modulation of transmitter release.39 Similarly, expression of CB1Rs has been found to be up-regulated in rats during an experimental intestinal inflammation.26,40
CB1Rs Binding (association) of in neurons associated with colitis, endocannabinoid and inflammation
19) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.25 Pain Relevance 0.56
The ratio of CB1Rs and ?
CB1Rs Binding (ratio) of
20) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0 Pain Relevance 0

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