INT50309

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 5.40
Pain Relevance 4.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
plasma 1
neurons 1
cerebrospinal fluid 1
temporomandibular joint 1
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 24 100.00 Very High Very High Very High
Cannabinoid 4 99.40 Very High Very High Very High
substance P 8 99.00 Very High Very High Very High
Calcitonin gene-related peptide 6 97.84 Very High Very High Very High
Osteoarthritis 84 97.04 Very High Very High Very High
antidepressant 60 96.80 Very High Very High Very High
nMDA receptor 3 96.40 Very High Very High Very High
Neuropeptide 24 96.32 Very High Very High Very High
allodynia 36 96.20 Very High Very High Very High
Inflammation 202 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 84 98.76 Very High Very High Very High
Nociception 19 98.44 Very High Very High Very High
Osteoarthritis 89 97.04 Very High Very High Very High
Neuropathic Pain 61 96.20 Very High Very High Very High
INFLAMMATION 239 95.84 Very High Very High Very High
Temporomandibular Joint Syndrome 12 93.24 High High
Experimental Arthritis 7 90.08 High High
Esophageal Cancer 2 87.60 High High
Ganglion Cysts 2 83.04 Quite High
Amyloid Plaque 19 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we have characterized the hypothermic effect of the psychoactive cannabinoid HU-210, by investigating its interaction with the endogenous pyrogens, IL-1 and PGE2.
IL-1 Binding (interaction) of associated with cannabinoid
1) Confidence 0.40 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7617143 Disease Relevance 0.06 Pain Relevance 0.28
Immunoreactivity for IL-1RI was examined alone (DAB) and together with calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), CD31 or CD34 by multiple-labelling immunofluorescence.
IL-1RI Binding (Immunoreactivity) of
2) Confidence 0.31 Published 2009 Journal Int Endod J Section Body Doc Link 19732182 Disease Relevance 0.17 Pain Relevance 0
To study the interaction between human recombinant interleukin-1 alpha and the nervous system, substance P-, neurokinin A-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the cerebrospinal fluid, plasma, and temporomandibular joint (TMJ) perfusates of rats during acute experimental monarthritis were examined.
recombinant interleukin-1 alpha Binding (interaction) of in temporomandibular joint associated with snapping jaw, neuropeptide, calcitonin gene-related peptide and substance p
3) Confidence 0.28 Published 1996 Journal J Orofac Pain Section Abstract Doc Link 8995911 Disease Relevance 0.26 Pain Relevance 0.43
CONCLUSIONS: This study confirms that IL1A is associated with susceptibility to AS.
IL1A Binding (associated) of
4) Confidence 0.24 Published 2008 Journal Ann. Rheum. Dis. Section Body Doc Link 18063673 Disease Relevance 0.19 Pain Relevance 0
RESULTS: Strong association was observed with three single nucleotide polymorphisms (SNPs) in the IL1A gene (rs2856836, rs17561, rs1894399, p = 0.0036, 0.000019 and 0.0003, respectively).
IL1A Binding (association) of
5) Confidence 0.19 Published 2008 Journal Ann. Rheum. Dis. Section Body Doc Link 18063673 Disease Relevance 0.24 Pain Relevance 0
Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-2 (IL-2) and interleukin-10 (IL-10) levels in serum were determined with ELISA.
IL-1 Binding (interleukin-1) of
6) Confidence 0.12 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19169271 Disease Relevance 0.27 Pain Relevance 0
As seen from the table, incubation with IL-1?
IL-1 Binding (incubation) of
7) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.15 Pain Relevance 0.20
For example, the IL-1?
IL-1 Binding (example) of
8) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.31 Pain Relevance 0.25
To study the interaction between human recombinant interleukin-1 alpha and the nervous system, substance P-, neurokinin A-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the cerebrospinal fluid, plasma, and temporomandibular joint (TMJ) perfusates of rats during acute experimental monarthritis were examined.
recombinant interleukin-1 alpha Binding (interaction) of in plasma associated with snapping jaw, neuropeptide, calcitonin gene-related peptide and substance p
9) Confidence 0.09 Published 1996 Journal J Orofac Pain Section Abstract Doc Link 8995911 Disease Relevance 0.26 Pain Relevance 0.43
To study the interaction between human recombinant interleukin-1 alpha and the nervous system, substance P-, neurokinin A-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the cerebrospinal fluid, plasma, and temporomandibular joint (TMJ) perfusates of rats during acute experimental monarthritis were examined.
recombinant interleukin-1 alpha Binding (interaction) of in cerebrospinal fluid associated with snapping jaw, neuropeptide, calcitonin gene-related peptide and substance p
10) Confidence 0.09 Published 1996 Journal J Orofac Pain Section Abstract Doc Link 8995911 Disease Relevance 0.26 Pain Relevance 0.43
Analysis of each 2, 3, 4, 5-marker sliding window revealed association with the IL1A locus (especially haplotype rs12622683-rs11123148-rs10165537).
IL1A Binding (association) of
11) Confidence 0.07 Published 2008 Journal J. Rheumatol. Section Body Doc Link 18484691 Disease Relevance 0.06 Pain Relevance 0
Upon incubation with IL-1?
IL-1 Binding (incubation) of
12) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
Neurobiologically, one could have expected that subjects carrying the more active IL-1?
IL-1 Binding (subjects) of
13) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.07 Pain Relevance 0.38
A 304-bp PCR fragment of the IL-1?
IL-1 Binding (fragment) of
14) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.05 Pain Relevance 0
-511TT genotype is associated with an advantageous SSRI treatment response compared with the IL-1?
IL-1 Binding (associated) of associated with ssri
15) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.12 Pain Relevance 0.15
B DNA binding [66] and IL-1?
IL-1 Binding (binding) of
16) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.53 Pain Relevance 0.21
Through binding with its receptor on the neurons, IL-1?
IL-1 Binding (binding) of in neurons
17) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.58 Pain Relevance 0.96
Under these experimental conditions, COX-2 and mPGES-1 expression was induced from 6 hours, with maximal induction at 12 hours and 24 hours, respectively, after challenge with IL-1?
IL-1 Binding (challenge) of
18) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.04
Under IL-1-stimulated conditions, 10 ?
IL-1 Binding (Under) of
19) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.08
Real time PCR cycles were carried out for amplification of IL-1?
IL-1 Binding (amplification) of
20) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0 Pain Relevance 0.04

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