INT50313

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.09
Pain Relevance 5.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

htr (Mus musculus)
Pain Link Frequency Relevance Heat
tramadol 21 100.00 Very High Very High Very High
Cannabinoid 10 99.98 Very High Very High Very High
agonist 9 99.86 Very High Very High Very High
narcan 3 99.44 Very High Very High Very High
antagonist 16 99.24 Very High Very High Very High
opioid receptor 9 99.00 Very High Very High Very High
Morphine 3 98.76 Very High Very High Very High
fluoxetine 6 97.52 Very High Very High Very High
Desipramine 1 95.84 Very High Very High Very High
Kappa opioid receptor 9 94.80 High High
Disease Link Frequency Relevance Heat
Depression 2 92.92 High High
Affective Disorder 1 5.00 Very Low Very Low Very Low
Tourette's Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induced HTR was depressed by pretreatment with cycloheptadine, p-chlorophenylalanine or fluoxetine, but was potentiated by 5,7-dihydroxytryptamine.
Negative_regulation (depressed) of Positive_regulation (induced) of HTR associated with fluoxetine
1) Confidence 0.51 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7617148 Disease Relevance 0 Pain Relevance 0.18
The tested cannabinoids reduced the frequencies of both DOI-induced HTR and ESR in a dose-dependent fashion.
Negative_regulation (reduced) of Positive_regulation (induced) of HTR associated with cannabinoid
2) Confidence 0.46 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11267636 Disease Relevance 0 Pain Relevance 0.51
Haloperidol can inhibit DOI-induced HTR in mice, but fluoxetine can not.


Negative_regulation (inhibit) of Positive_regulation (induced) of HTR
3) Confidence 0.38 Published 2007 Journal Zhongguo Dang Dai Er Ke Za Zhi Section Body Doc Link 17937861 Disease Relevance 0 Pain Relevance 0
In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR.
Negative_regulation (number) of Positive_regulation (induced) of HTR
4) Confidence 0.36 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16530230 Disease Relevance 0.09 Pain Relevance 0.47
In conclusion, administration of tramadol systemically inhibits 5-HTP-induced HTR in mice by activating opiatergic system in the CNS.
Negative_regulation (inhibits) of Positive_regulation (induced) of HTR associated with tramadol
5) Confidence 0.23 Published 2003 Journal Life Sci. Section Abstract Doc Link 12570923 Disease Relevance 0 Pain Relevance 1.28
Furthermore, the nonselective opioid receptor antagonists, naloxone and diprenorphine (M5050), reversed the effect of tramadol on 5-HTP-induced HTR dose-dependently.
Negative_regulation (reversed) of Positive_regulation (induced) of HTR associated with tramadol, antagonist, narcan and opioid receptor
6) Confidence 0.23 Published 2003 Journal Life Sci. Section Abstract Doc Link 12570923 Disease Relevance 0 Pain Relevance 1.33
Tramadol attenuated 5-HTP-induced HTR in a dose-dependent manner as morphine.
Negative_regulation (attenuated) of Positive_regulation (induced) of HTR associated with tramadol and morphine
7) Confidence 0.23 Published 2003 Journal Life Sci. Section Abstract Doc Link 12570923 Disease Relevance 0 Pain Relevance 1.23
The HTR induced by BZ-RAs was suppressed by pretreatment with ketanserine (1 mg/kg, i.p.), a selective 5-HT(2) receptor antagonist.
Negative_regulation (suppressed) of Positive_regulation (induced) of HTR associated with antagonist
8) Confidence 0.17 Published 2001 Journal Pharmacology Section Abstract Doc Link 11287817 Disease Relevance 0 Pain Relevance 0.31
Pretreatment with fluoxetine (10 mg/kg, i.p.), a 5-HT reuptake inhibitor, and 8-hydroxy-2-(di-n-propylamino)tetralin, a 5-HT(1A) receptor agonist, also suppressed the HTR induced by BZ-RAs.
Negative_regulation (suppressed) of Positive_regulation (induced) of HTR associated with agonist and fluoxetine
9) Confidence 0.17 Published 2001 Journal Pharmacology Section Abstract Doc Link 11287817 Disease Relevance 0 Pain Relevance 0.31

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