INT50325

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.40
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Vgf) extracellular space (Vgf) extracellular region (Vgf)
Anatomy Link Frequency
nerve 1
peripheral nerve 1
hindlimb 1
DRG 1
dorsal horn 1
Vgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 100.00 Very High Very High Very High
Peripheral nerve injury 35 99.64 Very High Very High Very High
Neuropathic pain 55 99.52 Very High Very High Very High
Dorsal horn 90 99.36 Very High Very High Very High
depression 5 98.20 Very High Very High Very High
Hippocampus 15 97.24 Very High Very High Very High
Dorsal horn neuron 65 95.04 Very High Very High Very High
Central nervous system 1 90.00 High High
Spinal cord 45 88.40 High High
Peripheral nervous system 5 85.00 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 25 99.72 Very High Very High Very High
Neuropathic Pain 85 99.52 Very High Very High Very High
Nervous System Injury 155 99.20 Very High Very High Very High
Depression 5 98.20 Very High Very High Very High
Injury 55 95.24 Very High Very High Very High
INFLAMMATION 5 68.36 Quite High
Nociception 10 62.76 Quite High
Hyperalgesia 5 33.08 Quite Low
Pain 10 32.52 Quite Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A developmentally regulated nerve growth factor-induced gene, VGF, is expressed in geniculocortical afferents during synaptogenesis.
Regulation (regulated) of VGF in nerve associated with nerve growth factor
1) Confidence 0.62 Published 1995 Journal Neuroscience Section Title Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.14
Despite the reported regulation of VGF mRNA by peripheral nerve injury, it is not known if VGF plays a role in neuropathic pain.
Regulation (regulation) of VGF in peripheral nerve associated with nervous system injury, neuropathic pain and peripheral nerve injury
2) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.00 Pain Relevance 0.69
Since VGF is highly regulated in the DRG and dorsal horn following peripheral nerve injury, we hypothesized that it may have a role in the behavioral hypersensitivity to touch and cold that is a characteristic of neuropathic pain.
Regulation (regulated) of VGF in dorsal horn associated with nervous system injury, hypersensitivity, neuropathic pain, dorsal horn and peripheral nerve injury
3) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.78 Pain Relevance 0.41
More recently, VGF regulation has been associated with synaptic strengthening and learning in the hippocampus [15] and to act downstream of BDNF to increase cell division in the hippocampus and counteract depression in animal models [16].
Regulation (regulation) of VGF in hippocampus associated with depression and hippocampus
4) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.71 Pain Relevance 0.56
Figure 2A shows the low level of VGF immunoreactivity in naïve L4 DRG compared to the ipsilateral L4 DRG 7 days following SNI in figure 2B.
Regulation (immunoreactivity) of VGF in DRG associated with nervous system injury
5) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.94 Pain Relevance 0.20
We used the hindlimb spared nerve injury (SNI) model of neuropathic pain to examine the dynamic regulation of VGF in primary sensory neurons in the rat L4/L5 dorsal root ganglia (DRG).
Spec (examine) Regulation (regulation) of VGF in hindlimb associated with nervous system injury and neuropathic pain
6) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.97 Pain Relevance 0.58

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