INT50326

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.41
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Vgf) extracellular space (Vgf) extracellular region (Vgf)
Anatomy Link Frequency
neurons 2
nerve 2
peripheral nerve 2
Brain 1
dorsal lateral geniculate nucleus 1
Vgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 16 100.00 Very High Very High Very High
Nerve growth factor 14 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Dorsal horn 91 99.20 Very High Very High Very High
Sciatic nerve 18 97.88 Very High Very High Very High
Peripheral nerve injury 45 97.68 Very High Very High Very High
dorsal root ganglion 25 96.08 Very High Very High Very High
Spinal cord 47 94.96 High High
Neuropathic pain 57 91.80 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 169 99.00 Very High Very High Very High
Injury 70 98.68 Very High Very High Very High
Nociception 10 98.64 Very High Very High Very High
Ganglion Cysts 30 96.08 Very High Very High Very High
Hypersensitivity 25 94.16 High High
Neuropathic Pain 87 91.80 High High
Diabetes Mellitus 90 66.96 Quite High
Pain 11 62.92 Quite High
Cognitive Disorder 11 55.36 Quite High
Stress 10 54.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spatiotemporal expression of VGF, together with the observation of a regulation by electrical activity, suggest that this protein may be relevant in the process of synaptogenesis and/or synaptic stabilization in the developing geniculocortical connections.
Gene_expression (expression) of VGF
1) Confidence 0.78 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.18
After its onset at E16, VGF messenger RNA expression increases progressively in the dorsal lateral geniculate nucleus and remains high during the first two post-natal weeks; afterwards, it gradually decreases and, at the offset of the plasticity period, it reaches very low levels maintained in adulthood.
Gene_expression (expression) of VGF messenger RNA in dorsal lateral geniculate nucleus
2) Confidence 0.78 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.12
A developmentally regulated nerve growth factor-induced gene, VGF, is expressed in geniculocortical afferents during synaptogenesis.
Gene_expression (expressed) of VGF in nerve associated with nerve growth factor
3) Confidence 0.78 Published 1995 Journal Neuroscience Section Title Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.14
Increased VGF expression was observed in both large and small diameter DRG neurons and staining was cytoplasmic and punctate in nature, consistent with its storage in secretory vesicles (Levi et al., 2004).
Gene_expression (expression) of VGF in neurons
4) Confidence 0.78 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.98 Pain Relevance 0.09
Figure 2D shows that increased VGF expression in ipsilateral L4 DRG 7 days post injury is largely, but not entirely restricted to injured neurons.
Gene_expression (expression) of VGF in neurons associated with injury
5) Confidence 0.78 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.93 Pain Relevance 0.10
A similar pattern of upregulation of VGF protein expression is observed in the dorsal horn (Figure 3A–D).
Gene_expression (expression) of VGF protein in dorsal horn associated with dorsal horn
6) Confidence 0.78 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.50 Pain Relevance 0.32
The expression of the nerve growth factor-inducible gene VGF has been examined by in situ hybridization.
Gene_expression (expression) of VGF in nerve associated with nerve growth factor
7) Confidence 0.60 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.13
Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury

Background

Gene_expression (expression) of VGF in peripheral nerve associated with nervous system injury, neuropeptide and peripheral nerve injury
8) Confidence 0.60 Published 2008 Journal Mol Pain Section Title Doc Link PMC2614976 Disease Relevance 0.69 Pain Relevance 0.62
VGF expression is therefore highly modulated in nociceptive pathways following peripheral nerve injury and can cause dorsal horn cell excitation and behavioral hypersensitivity in naïve animals.
Gene_expression (expression) of VGF in peripheral nerve associated with nociception, nervous system injury, hypersensitivity, dorsal horn and peripheral nerve injury
9) Confidence 0.60 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2614976 Disease Relevance 0.78 Pain Relevance 0.67
Of the genes listed in Table 4, seven were found in both studies (Peripheral Benzodiazepine receptor, 5HT3, Gadd45, CLP36, Lysozyme, SNAP25 and VGF).
Gene_expression (found) of VGF
10) Confidence 0.50 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139981 Disease Relevance 0.17 Pain Relevance 0.21
Genes whose transcription is regulated by CREB include: c-fos, BDNF (Brain-derived neurotrophic factor), tyrosine hydroxylase and neuropeptides such as somatostatin, enkephalin, VGF and corticotropin-releasing hormone [21].
Gene_expression (include) of VGF in Brain associated with somatostatin, neuropeptide and enkephalin
11) Confidence 0.45 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.35 Pain Relevance 0.61

General Comments

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