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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.33

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generation of precursor metabolites and energy (Vgf) extracellular space (Vgf) extracellular region (Vgf)
Anatomy Link Frequency
dorsal lateral geniculate nucleus 1
nucleus 1
Vgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.80 Very High Very High Very High
Morphine 1 95.10 Very High Very High Very High
Neuropeptide 2 86.88 High High
Nerve growth factor 2 75.00 Quite High
Central nervous system 1 58.08 Quite High
Disease Link Frequency Relevance Heat
Erectile Dysfunction 7 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, we found that the blockade of afferent electrical activity by intraocular injection of tetrodotoxin strongly reduces the level of VGF messenger RNA in the dorsal lateral geniculate nucleus.
Negative_regulation (reduces) of VGF messenger RNA in dorsal lateral geniculate nucleus associated with tetrodotoxin
1) Confidence 0.43 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.24
VGF(588-617)-induced penile erection was reduced by nitro(omega)-L-arginine methylester (L-NAME; 20 microg), by morphine (5 microg) and by muscimol (1 microg), but not by dizocilpine [(+)MK-801; 1 microg], nor by cis-flupenthixol (10 microg) given into the paraventricular nucleus 10 min before the VGF peptide. d(CH2)5Tyr(Me)-Orn8-vasotocin (1 microg) effectively reduced VGF(588-617)-induced penile erection when given into the lateral ventricles but not when injected into the paraventricular nucleus.
Negative_regulation (reduced) of VGF in nucleus associated with erectile dysfunction and morphine
2) Confidence 0.37 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.48 Pain Relevance 0.10

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