INT50328

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 23
Disease Relevance 13.98
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Vgf) extracellular space (Vgf) extracellular region (Vgf)
Anatomy Link Frequency
nucleus 6
dorsal horn 5
nerve 4
neurons 2
dorsal root ganglia 2
Vgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 144 100.00 Very High Very High Very High
Nerve growth factor 18 99.98 Very High Very High Very High
Dorsal horn neuron 208 99.84 Very High Very High Very High
Dorsal horn 288 99.44 Very High Very High Very High
Neuropathic pain 176 99.12 Very High Very High Very High
Neuronal excitability 32 98.64 Very High Very High Very High
Root ganglion neuron 16 98.04 Very High Very High Very High
Peripheral nerve injury 112 96.84 Very High Very High Very High
Spinal cord 144 95.40 Very High Very High Very High
depression 16 93.08 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 496 99.96 Very High Very High Very High
Injury 176 99.60 Very High Very High Very High
Erectile Dysfunction 42 99.44 Very High Very High Very High
Neuropathic Pain 272 99.12 Very High Very High Very High
Ganglion Cysts 16 97.84 Very High Very High Very High
Hypersensitivity 80 93.52 High High
Depression 16 93.08 High High
INFLAMMATION 16 90.80 High High
Nociception 32 85.20 High High
Hyperalgesia 16 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together these data show strong and selective upregulation of VGF mRNA and protein in dorsal horn neurons and terminals following nerve injury.


Positive_regulation (upregulation) of VGF in dorsal horn associated with nervous system injury and dorsal horn neuron
1) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.74 Pain Relevance 0.37
The results show that the polypeptide VGF is strongly upregulated in injured DRG neurons and their central target dorsal horn neurons following SNI.
Positive_regulation (upregulated) of VGF in neurons associated with nervous system injury and dorsal horn neuron
2) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.32 Pain Relevance 0.35
In addition, VGF protein is upregulated in intrinsic neurons in both superficial and deep laminae following nerve injury.
Positive_regulation (upregulated) of VGF protein in nerve associated with nervous system injury
3) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.33 Pain Relevance 0.23
Taken together these data clearly show strong upregulation of VGF mRNA and protein in injured DRG neurons following nerve injury.


Positive_regulation (upregulation) of VGF in nerve associated with nervous system injury
4) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.89 Pain Relevance 0.16
VGF mRNA and protein is also increased in the L4/L5 dorsal horn after SNI.
Positive_regulation (increased) of VGF in dorsal horn associated with nervous system injury and dorsal horn
5) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.88 Pain Relevance 0.24
The striking upregulation of VGF in sensory neurons following nerve injury is reminiscent of the selective and maintained activation of VGF in other brain regions in response to neurotropins and prolonged neuronal depolarization [13,15,14] and is likely to result from injury induced spike activity and neurotrophin upregulation in the DRG and dorsal horn.
Positive_regulation (upregulation) of VGF in neuronal associated with nervous system injury, injury and dorsal horn
6) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.69 Pain Relevance 0.43
To establish whether the VGF upregulation was in neurons whose axons were damaged by SNI surgery, we applied a retrograde tracer (True blue) to the cut end of the peripheral nerves at the time of the injury.
Spec (whether) Positive_regulation (upregulation) of VGF in peripheral nerves associated with nervous system injury and injury
7) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.90 Pain Relevance 0.06
The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.
Positive_regulation (portion) of VGF in nucleus associated with erectile dysfunction
8) Confidence 0.50 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.31 Pain Relevance 0.06
The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.
Positive_regulation (portion) of VGF in nucleus associated with erectile dysfunction
9) Confidence 0.50 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.32 Pain Relevance 0.06
The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.
Positive_regulation (portion) of VGF in nucleus associated with erectile dysfunction
10) Confidence 0.50 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.32 Pain Relevance 0.06
The expression of the nerve growth factor-inducible gene VGF has been examined by in situ hybridization.
Positive_regulation (inducible) of VGF in nerve associated with nerve growth factor
11) Confidence 0.47 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.13
Prolonged upregulation of VGF mRNA and protein was observed in injured dorsal root ganglion neurons, central terminals and their target dorsal horn neurons.
Positive_regulation (upregulation) of VGF in neurons associated with ganglion cysts, root ganglion neuron and dorsal horn neuron
12) Confidence 0.47 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2614976 Disease Relevance 0.63 Pain Relevance 0.65
Here we report that VGF is upregulated in both DRG and dorsal horn neurons in a model of neuropathic pain and show that VGF peptide application to the naïve spinal cord directly influences dorsal horn neuron excitability and induces typical neuropathic behavior.


Positive_regulation (upregulated) of VGF in dorsal horn associated with neuropathic pain, dorsal horn neuron and spinal cord
13) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.05 Pain Relevance 0.72
Pattern of VGF mRNA and protein upregulation in dorsal horn neurons following spared nerve injury
Positive_regulation (upregulation) of VGF in dorsal horn associated with nervous system injury and dorsal horn neuron
14) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.89 Pain Relevance 0.17
Pattern of VGF mRNA and protein upregulation in DRG neurons following spared nerve injury
Positive_regulation (upregulation) of VGF in nerve associated with nervous system injury
15) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.01 Pain Relevance 0.61
Figure 1A shows that SNI triggers a sustained 3 fold upregulation of VGF mRNA that is maintained for at least 3 weeks.
Positive_regulation (upregulation) of VGF associated with nervous system injury
16) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.99 Pain Relevance 0.51
VGF protein is also upregulated in the L4 and L5 DRG following SNI.
Positive_regulation (upregulated) of VGF protein in DRG associated with nervous system injury
17) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.01 Pain Relevance 0.26
The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.
Positive_regulation (portion) of VGF in nucleus associated with erectile dysfunction
18) Confidence 0.44 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.32 Pain Relevance 0.06
The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.
Positive_regulation (portion) of VGF in nucleus associated with erectile dysfunction
19) Confidence 0.44 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.32 Pain Relevance 0.06
The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.
Positive_regulation (portion) of VGF in nucleus associated with erectile dysfunction
20) Confidence 0.44 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.33 Pain Relevance 0.06

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