INT50329

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.45
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Vgf) extracellular space (Vgf) extracellular region (Vgf)
Anatomy Link Frequency
neurons 6
dorsal lateral geniculate nucleus 2
dorsal horn 2
Vgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 72 99.20 Very High Very High Very High
Spinal cord 36 94.96 High High
Central nervous system 1 90.24 High High
Nerve growth factor 6 83.72 Quite High
Dorsal horn neuron 52 77.52 Quite High
dorsal rhizotomy 4 67.04 Quite High
Neuropathic pain 44 60.84 Quite High
medulla 4 51.84 Quite High
Neuropeptide 9 50.00 Quite Low
Peripheral nerve injury 28 41.12 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 124 99.40 Very High Very High Very High
Injury 44 99.08 Very High Very High Very High
Neuropathic Pain 68 60.84 Quite High
Depression 4 37.36 Quite Low
Hypersensitivity 20 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After its onset at E16, VGF messenger RNA expression increases progressively in the dorsal lateral geniculate nucleus and remains high during the first two post-natal weeks; afterwards, it gradually decreases and, at the offset of the plasticity period, it reaches very low levels maintained in adulthood.
Positive_regulation (increases) of Gene_expression (expression) of VGF messenger RNA in dorsal lateral geniculate nucleus
1) Confidence 0.70 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.12
Figure 2D shows that increased VGF expression in ipsilateral L4 DRG 7 days post injury is largely, but not entirely restricted to injured neurons.
Positive_regulation (increased) of Gene_expression (expression) of VGF in neurons associated with injury
2) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.93 Pain Relevance 0.10
Increased VGF expression was observed in both large and small diameter DRG neurons and staining was cytoplasmic and punctate in nature, consistent with its storage in secretory vesicles (Levi et al., 2004).
Positive_regulation (Increased) of Gene_expression (expression) of VGF in neurons
3) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.98 Pain Relevance 0.11
A similar pattern of upregulation of VGF protein expression is observed in the dorsal horn (Figure 3A–D).
Positive_regulation (upregulation) of Gene_expression (expression) of VGF protein in dorsal horn associated with dorsal horn
4) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.56 Pain Relevance 0.32
Increased VGF expression was observed in both large and small diameter DRG neurons and staining was cytoplasmic and punctate in nature, consistent with its storage in secretory vesicles (Levi et al., 2004).
Positive_regulation (observed) of Gene_expression (expression) of VGF in neurons
5) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.98 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox