INT5033

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Context Info
Confidence 0.54
First Reported 1986
Last Reported 2008
Negated 1
Speculated 2
Reported most in Abstract
Documents 39
Total Number 41
Disease Relevance 13.37
Pain Relevance 48.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tail 5
plasma 4
RVM 3
EM-2 3
spinal 3
tf (Mus musculus)
Pain Link Frequency Relevance Heat
tail-flick 237 100.00 Very High Very High Very High
antinociception 57 100.00 Very High Very High Very High
Central grey 72 99.98 Very High Very High Very High
Opioid 50 99.98 Very High Very High Very High
Morphine 224 99.82 Very High Very High Very High
Rostral ventromedial medulla 43 99.80 Very High Very High Very High
antagonist 38 99.76 Very High Very High Very High
Neurotransmitter 7 99.72 Very High Very High Very High
amygdala 27 99.48 Very High Very High Very High
analgesia 19 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 51 100.00 Very High Very High Very High
Urological Neuroanatomy 73 99.98 Very High Very High Very High
Pressure Volume 2 Under Development 12 99.60 Very High Very High Very High
Heart Rate Under Development 21 99.52 Very High Very High Very High
Cv General 3 Under Development 18 99.44 Very High Very High Very High
Cv Unclassified Under Development 10 99.08 Very High Very High Very High
Hypopituitarism 11 96.12 Very High Very High Very High
Hypotension 12 95.16 Very High Very High Very High
Depression 3 95.00 High High
Necrosis 3 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that acute changes in blood pressure and respiration associated with i.v. 5-HT do not contribute to inhibition of the TF reflex.
Negative_regulation (inhibition) of TF in blood associated with cv unclassified under development and tail-flick
1) Confidence 0.54 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.68 Pain Relevance 0.49
Intrathecal pretreatment with EM-2 (0.02-1.75 nmol) 45 min before i.t. morphine (3.0 nmol) injection dose dependently attenuated morphine-induced TF inhibition.
Negative_regulation (inhibition) of TF in EM-2 associated with tail-flick, morphine and intrathecal
2) Confidence 0.49 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 1.68
Intrathecal pretreatment with dextro-morphine (33 fmol) time-dependently attenuated the i.t. levo-morphine-produced TF inhibition for 4 h and returned to the preinjection control level at 24 h.
Negative_regulation (inhibition) of TF associated with tail-flick, morphine and intrathecal
3) Confidence 0.48 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901793 Disease Relevance 0 Pain Relevance 1.77
Like levo-morphine, the dextro-morphine-induced antianalgesia against levo-morphine-produced TF inhibition was dose-dependently blocked by the nonopioid dextro-naloxone and its stereo-enantiomer levo-naloxone, a nonselective mu-opioid receptor antagonist.
Negative_regulation (inhibition) of TF associated with antagonist, narcan, tail-flick, opioid receptor and morphine
4) Confidence 0.40 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901793 Disease Relevance 0 Pain Relevance 2.32
Intrathecal pretreatment with dextro-morphine (0.3-33 fmol), which injected alone did not affect the baseline TF latency, dose-dependently attenuated the TF inhibition produced by i.t.
Negative_regulation (inhibition) of TF associated with tail-flick, morphine and intrathecal
5) Confidence 0.40 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901793 Disease Relevance 0 Pain Relevance 2.04
Intrathecal pretreatment with morphine (0.009-0.3 nmol) for 45 min also dose dependently attenuated morphine-produced TF inhibition.
Negative_regulation (inhibition) of TF associated with tail-flick, morphine and intrathecal
6) Confidence 0.40 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14999057 Disease Relevance 0 Pain Relevance 1.83
EM-2 pretreatment also attenuated the TF inhibition induced by other mu-opioid agonists, [d-Ala2,N-Me-Phe4,Gly-ol5]-enkephalin, EM-1 and EM-2, delta-opioid agonist deltorphin II, and kappa-opioid agonist (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide methane-sulfonate hydrate (U50,488H).
Negative_regulation (inhibition) of TF in EM-2 associated with mu agonist, tail-flick and enkephalin
7) Confidence 0.36 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 2.35
The EM-2 (1.75 nmol)-produced anti-analgesia against morphine-induced TF inhibition was blocked by i.t. pretreatment with the mu-opioid antagonist naloxone or 3-methoxynaltrexone, but not delta-opioid receptor antagonist naltrindole, kappa-opioid receptor antagonist nor-binaltorphimine, or N-methyl-d-aspartate (NMDA) receptor antagonist MK-801.
Negative_regulation (inhibition) of TF in EM-2 associated with kappa opioid receptor, narcan, tail-flick, opioid receptor, morphine, analgesia, antagonist and opioid
8) Confidence 0.36 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 1.98
Intrathecal pretreatment with low dose (0.3 nmol) of morphine time dependently attenuated i.t. morphine-produced (3.0 nmol) TF inhibition and reached a maximal effect at 45 min.
Negative_regulation (inhibition) of TF associated with tail-flick, morphine and intrathecal
9) Confidence 0.35 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14999057 Disease Relevance 0 Pain Relevance 1.73
A variety of anatomical and pharmacological manipulations were performed to characterize the 5-HT-induced inhibition of the TF reflex and associated changes in blood pressure.
Negative_regulation (inhibition) of TF in blood associated with cv unclassified under development and tail-flick
10) Confidence 0.34 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.76 Pain Relevance 0.27
This conclusion was confirmed in experiments in which bilateral vagotomy abolished approximately 70% of the 5-HT-induced inhibition of the TF reflex (and all depressor responses), and resulted in a significantly greater pressor response.
Negative_regulation (inhibition) of TF associated with tail-flick
11) Confidence 0.34 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.56 Pain Relevance 0.48
Intravenous 5-HT produced a dose-dependent (6-192 micrograms/kg, i.v.) inhibition of the nociceptive tail-flick (TF) reflex in lightly pentobarbital-anesthetized (ED50 = 40 micrograms/kg) and conscious rats (ED50 = 44 micrograms/kg).
Negative_regulation (inhibition) of TF in tail associated with nociception and tail-flick
12) Confidence 0.34 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.47 Pain Relevance 0.18
The i.t. morphine pretreatment also attenuated the TF inhibition produced by opioid muagonist [D-Ala2, N-Me-Phe4,Gly-ol5]-enkephalin, delta-agonist deltorphin II, and kappa-agonist U50,488H.
Negative_regulation (inhibition) of TF associated with agonist, tail-flick, enkephalin, opioid and morphine
13) Confidence 0.29 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14999057 Disease Relevance 0 Pain Relevance 2.75
Distinct opioid antagonists had differential effects on antinociception: naltrindole (delta-antagonist) partially blocked antinociception in the TF, but it was ineffective in the HP test, whereas beta-funaltrexamine (irreversible antagonist, mu(1)/mu(2)-subtypes) but not naloxonazine (mu(1)-subtype) inhibited TF test antinociception, yet both blocked antinociception in the HP test.
Negative_regulation (blocked) of TF associated with antinociception, antagonist, tail-flick and opioid
14) Confidence 0.28 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718580 Disease Relevance 0 Pain Relevance 1.68
Administration of CNTO859 significantly reduced both TF and PAI-1 activities in the plasma (Fig. 3A and 3B), and dramatically attenuated the IIR-induced alveolar fibrin deposition (Fig. 3C and 3D).
Negative_regulation (reduced) of TF in plasma
15) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.03 Pain Relevance 0.09
Distinct opioid antagonists had differential effects on antinociception: naltrindole (delta-antagonist) partially blocked antinociception in the TF, but it was ineffective in the HP test, whereas beta-funaltrexamine (irreversible antagonist, mu(1)/mu(2)-subtypes) but not naloxonazine (mu(1)-subtype) inhibited TF test antinociception, yet both blocked antinociception in the HP test.
Negative_regulation (inhibited) of TF associated with antinociception, antagonist, tail-flick and opioid
16) Confidence 0.24 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718580 Disease Relevance 0 Pain Relevance 1.78
Bicuculline and picrotoxin microinjected into the ventrolateral aspect of the caudal PAG inhibited the TF, increased the spontaneous activity of the off-cells and decreased that of the on-cells.
Negative_regulation (inhibited) of TF associated with central grey
17) Confidence 0.20 Published 1986 Journal Brain Res. Section Abstract Doc Link 3801864 Disease Relevance 0.49 Pain Relevance 0.78
Opioid inhibition of the TF was also reduced, although baseline TF latency was unaffected, by RVM kynurenate.
Negative_regulation (inhibition) of TF in RVM associated with opioid and rostral ventromedial medulla
18) Confidence 0.19 Published 1999 Journal Pain Section Abstract Doc Link 10353493 Disease Relevance 0.19 Pain Relevance 1.62
Opioid inhibition of the TF was also reduced, although baseline TF latency was unaffected, by RVM kynurenate.
Neg (unaffected) Negative_regulation (unaffected) of TF in RVM associated with opioid and rostral ventromedial medulla
19) Confidence 0.12 Published 1999 Journal Pain Section Abstract Doc Link 10353493 Disease Relevance 0.19 Pain Relevance 1.57
Microinjection of either lidocaine or ibotenic acid into the nuclei tracti solitarii (NTS), rostromedial medulla (RMM), or ventrolateral pontine tegmentum (VLPT) attenuated morphine-induced inhibition of the TF reflex.
Negative_regulation (inhibition) of TF in VLPT associated with medulla, tail-flick, lidocaine and morphine
20) Confidence 0.07 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1432065 Disease Relevance 0.41 Pain Relevance 1.56

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