INT50330

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.76
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
nucleus accumbens 1
shell 1
forebrain 1
cortex 1
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 21 100.00 Very High Very High Very High
Nucleus accumbens 15 99.92 Very High Very High Very High
GABAergic 58 99.68 Very High Very High Very High
Neurotransmitter 18 99.46 Very High Very High Very High
butorphanol 11 99.22 Very High Very High Very High
fluoxetine 3 98.28 Very High Very High Very High
Morphine 12 98.20 Very High Very High Very High
Endep 4 97.72 Very High Very High Very High
Somatosensory cortex 2 97.56 Very High Very High Very High
agonist 37 97.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 23 87.32 High High
Toxicity 1 86.80 High High
Shock 1 79.24 Quite High
Cancer 52 74.40 Quite High
Necrosis 2 73.92 Quite High
INFLAMMATION 19 5.00 Very Low Very Low Very Low
Depression 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that activation of the D3-receptor in the mesolimbic dopamine system may attenuate the expression of morphine-induced hyperlocomotion.
Positive_regulation (activation) of D3-receptor associated with dopamine and morphine
1) Confidence 0.70 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7617299 Disease Relevance 0 Pain Relevance 0.69
The present findings indicate that direct and indirect DA agonists share similar stimulus effects with a low but not high training dose of butorphanol, and in the high-training dose group, activation of the D3 receptor by (+/-)-7-OHDPAT results in the attenuation of the discriminative stimulus effects of mu opioids.
Positive_regulation (activation) of D3 receptor associated with dopamine, butorphanol, agonist and opioid
2) Confidence 0.67 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9537683 Disease Relevance 0 Pain Relevance 1.50
These results confirm the role of DRD3 in the expression of conditioned effects of morphine and the participation of the somatosensory cortex in these effects.
Positive_regulation (role) of DRD3 in cortex associated with somatosensory cortex and morphine
3) Confidence 0.50 Published 2004 Journal Neuroreport Section Abstract Doc Link 15371743 Disease Relevance 0.16 Pain Relevance 0.73
Here we found that prenatal and neonatal exposure to BPA resulted in the attenuation of dopamine D3 receptor-mediated G-protein activation by 7-OH-DPAT in the mouse limbic forebrain.
Positive_regulation (activation) of dopamine D3 receptor in forebrain associated with dopamine
4) Confidence 0.46 Published 2004 Journal Addict Biol Section Abstract Doc Link 15203435 Disease Relevance 0.09 Pain Relevance 0.41
ECT for 10 days increased D3 receptor mRNA and binding in the shell of nucleus accumbens.
Positive_regulation (increased) of D3 receptor in shell associated with nucleus accumbens
5) Confidence 0.31 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.08 Pain Relevance 0.90
An example for neurotransmitter receptor crosstalk is the activation of the dopamine D3 receptor in the GABAergic medium spiny neurons of the nucleus accumbens.
Positive_regulation (activation) of D3 receptor in nucleus accumbens associated with nucleus accumbens, dopamine, neurotransmitter and gabaergic
6) Confidence 0.07 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.21 Pain Relevance 0.42
Activation of the D3 receptor resulted in a reduction of GABAA receptor currents, that was dependent on PKA activity, dynamin and an atypical AP-2 binding motif on the beta3 subunit with a critical PKA site, that needs to be dephosphorylated to mediate the effect (Chen et al., 2006; Kittler et al., 2005).
Positive_regulation (Activation) of D3 receptor
7) Confidence 0.06 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.22 Pain Relevance 0.44
Only vitamin D3 receptor is known to be stabilized by
Positive_regulation (stabilized) of D3 receptor
8) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0 Pain Relevance 0

General Comments

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