INT50334

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 84
Total Number 87
Disease Relevance 30.86
Pain Relevance 51.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
brain 5
neurons 5
caudate-putamen 2
neural 2
spinal 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 2037 100.00 Very High Very High Very High
Endocannabinoid 1020 100.00 Very High Very High Very High
antagonist 419 100.00 Very High Very High Very High
Cannabinoid receptor 299 100.00 Very High Very High Very High
Glutamate 254 100.00 Very High Very High Very High
agonist 1335 99.98 Very High Very High Very High
Eae 106 99.98 Very High Very High Very High
Paracetamol 92 99.90 Very High Very High Very High
opioid receptor 105 99.84 Very High Very High Very High
analgesia 382 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 235 100.00 Very High Very High Very High
Vomiting 25 100.00 Very High Very High Very High
Injury 83 99.98 Very High Very High Very High
Neurodegenerative Disease 487 99.92 Very High Very High Very High
Inflammatory Pain 11 99.50 Very High Very High Very High
Epilepsy 218 99.12 Very High Very High Very High
Nociception 147 99.00 Very High Very High Very High
Stress 170 98.78 Very High Very High Very High
Anxiety Disorder 218 98.76 Very High Very High Very High
Multiple Sclerosis 82 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of hilar mossy cells and GABAergic interneurons during the development of TLE in similar models [55] and the concomitant loss of CB1R associated with these nerve terminals could contribute to a reduction in the density of CB1R observed in immunohistochemical analyses.
Negative_regulation (loss) of CB1R in nerve associated with epilepsy and gabaergic
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.58 Pain Relevance 0.37
Thus, it is likely that the analgesic desensitization promoted after several days of systemic treatment with cannabinoids primarily affects receptors at the spinal and peripheral levels, and the associated downregulation of the supraspinal CB1Rs, about 30–50% [5,62], may be secondary to these effects.
Negative_regulation (downregulation) of CB1Rs in spinal associated with cannabinoid and analgesic
2) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.06 Pain Relevance 0.67
CB1-GASP1 interaction was observed to be required for agonist-induced downregulation of CB1 in spinal neurons ex vivo as well as in vivo.
Negative_regulation (downregulation) of CB1 in neurons associated with cannabinoid receptor and agonist
3) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428994 Disease Relevance 0.08 Pain Relevance 1.25
These data revealed specific changes induced by neuropathic pain in MOR expression and c-fos levels in the DRG and/or spinal cord that were not modified by the genetic disruption of CB1 cannabinoid receptors.
Negative_regulation (disruption) of CB1 in DRG associated with cannabinoid receptor, neuropathic pain and spinal cord
4) Confidence 0.57 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16360182 Disease Relevance 0.80 Pain Relevance 0.79
In our previous study, we demonstrated that chronic ethanol (EtOH) exposure down-regulated the cannabinoid receptors (CB1) in mouse brain synaptic plasma membrane (SPM) (Basavarajappa et al., Brain Res. 793 (1998) 212-218).
Negative_regulation (down-regulated) of CB1 in Brain associated with cannabinoid receptor
5) Confidence 0.56 Published 1999 Journal Brain Res. Section Abstract Doc Link 9974126 Disease Relevance 0 Pain Relevance 0.26
These results suggest that the observed down-regulation of CB1 receptors by chronic EtOH has a profound effect on desensitization of cannabinoid-activated signal transduction and possible involvement of CB1 receptors in EtOH tolerance and dependence.
Negative_regulation (down-regulation) of CB1 associated with addiction, cannabinoid receptor, cannabinoid and tolerance
6) Confidence 0.56 Published 1999 Journal Brain Res. Section Abstract Doc Link 9974126 Disease Relevance 0 Pain Relevance 0.44
Accordingly, Koethe et al[101] found a decrease of CB1 receptor density in the glial cells of the grey matter in the brain of post-mortem patients suffering from major depression.


Negative_regulation (decrease) of CB1 in brain associated with depression
7) Confidence 0.55 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 1.16 Pain Relevance 0.59
Furthermore, exposure to chronic stress is capable of down-regulating the endocannabinoid system by reducing CB1 receptor density and 2-AG levels in the hippocampus [76].
Negative_regulation (reducing) of CB1 in hippocampus associated with stress, endocannabinoid and hippocampus
8) Confidence 0.55 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 1.34 Pain Relevance 0.43
We show that the cannabinoid receptor 1 receptor is severely and rapidly downregulated in the R6/1 mouse between the 8(th) to the 10(th) week of age.
Negative_regulation (downregulated) of cannabinoid receptor 1 receptor associated with cannabinoid receptor
9) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643771 Disease Relevance 0.68 Pain Relevance 0.23
Within the SCN, cannabinoids were excitatory by a mechanism based on presynaptic CB1R attenuation of axonal GABA release.
Negative_regulation (attenuation) of CB1R in SCN associated with gaba and cannabinoid
10) Confidence 0.49 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668190 Disease Relevance 0 Pain Relevance 0.56
In a more recent study, Kamprath et al. [111] have found that CB1-KO mice were severely impaired not only in extinction of the fear response to a tone after fear conditioning, but also in habituation of the fear response to a tone after sensitization with an inescapable footshock.
Negative_regulation (impaired) of CB1 associated with targeted disruption and anxiety disorder
11) Confidence 0.47 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906867 Disease Relevance 0.91 Pain Relevance 0.13
We can hypothesize that, when SR is administered jointly with WIN, the antagonist blocks the CB1 receptor and in that way inhibits WIN action, while at the same time decreasing the cannabinoid tone and indirectly increasing the rewarding action of MDMA.
Negative_regulation (blocks) of CB1 receptor associated with cannabinoid and antagonist
12) Confidence 0.47 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0.14 Pain Relevance 0.73
Evidence is then provided demonstrating a functional cross-talk between the cannabinoid and opioid systems in the mutual modulation of the addictive behavior; accordingly, very recent data from transgenic mice lacking either the cannabinoid CB1 or opioid receptors are also presented.
Negative_regulation (lacking) of CB1 associated with targeted disruption, cannabinoid, opioid receptor and opioid
13) Confidence 0.43 Published 2004 Journal Crit Rev Neurobiol Section Abstract Doc Link 15581410 Disease Relevance 0.19 Pain Relevance 1.02
mice lack CB1 also in a subgroup of pyramidal neurons in the layer VI of neocortex.
Negative_regulation (lack) of CB1 in pyramidal neurons associated with pyramidal cell
14) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0 Pain Relevance 0.23
mice, CB1 receptors are lost in all projecting neurons of the brain, thus making it difficult to define the exact site of action of THC to induce catalepsy.
Negative_regulation (lost) of CB1 in neurons associated with catalepsy
15) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.59 Pain Relevance 0.33
The loss of hilar mossy cells and GABAergic interneurons during the development of TLE in similar models [55] and the concomitant loss of CB1R associated with these nerve terminals could contribute to a reduction in the density of CB1R observed in immunohistochemical analyses.
Negative_regulation (reduction) of CB1R in nerve associated with epilepsy and gabaergic
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.58 Pain Relevance 0.36
Nevertheless, the absence of RGS9 did not affect the activity of WIN55,212-2 or its capacity to produce CB1R desensitization.
Negative_regulation (desensitization) of CB1R
17) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.30
A plausible explanation for the observed long-lasting single-dose desensitization of CB1Rs is that the agonists reduced the functional CB1Rs at the neural membrane.
Negative_regulation (desensitization) of CB1Rs in neural associated with agonist
18) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.80
Notably, the CB1R desensitization caused by a single dose of the cannabinoid agonist lasted for several days and the recovery of the response took 2 or 3 weeks (Fig. 1, lower panel).
Negative_regulation (desensitization) of CB1R associated with cannabinoid and agonist
19) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.38
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

Background

Negative_regulation (desensitization) of CB1 in brain associated with tolerance and morphine
20) Confidence 0.43 Published 2009 Journal Mol Pain Section Title Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.14

General Comments

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